RegulonDB RegulonDB 11.1:Regulon Page

YeiL DNA-binding transcriptional activator

Synonyms: YeiL
The genes that the YeiL transcriptional activator regulates have not been identified yet, but it has been proposed that this protein might regulate genes involved in post-exponential-phase nitrogen starvation. A gene encoding a potential nucleoside hydrolase and transcribed divergently from yeiL has also been suggested to be subject to YeiL regulation [2]. YeiL, the third member of the CRP/FNR family, has the main structural elements conserved in Crp and Fnr, such as a sensory domain, an α-helix that serves as a dimer interface, and a DNA-recognition helix also found in Fnr. However, the specific residues in the helix for DNA binding are not conserved [2]. The regulatory activity of this protein has been suggested by analogy with FNR; this activity might be modulated by a sensory iron-sulfur cluster or by reversible disulfide-bond formation. Expression of yeiL increases during stationary phase under aerobic conditions and is positively autoregulated [2]. Review: [3] Read more >

Transcription factor      
TF conformation(s):
Name Conformation Type TF-Effector Interaction Type Apo/Holo Conformation Evidence Confidence level (C: Confirmed, S: Strong, W: Weak) References
YeiL Functional   nd nd nd
Evolutionary Family: Cyclic nucleotide_binding domain
TFBs symmetry: inverted-repeat
Connectivity class: Local Regulator
Gene name: yeiL
  Genome position: 2255355-2256014
  Length: 660 bp / 219 aa
Operon name: yeiL
TU(s) encoding the TF:
Transcription unit        Promoter

Regulated gene(s) yeiL
Multifun term(s) of regulated gene(s) MultiFun Term (List of genes associated to the multifun term)
Transcription related (1)
activator (1)
Regulated operon(s) yeiL
First gene in the operon(s) yeiL
Simple and complex regulons FNR,IHF,Lrp,YeiL
Simple and complex regulatory phrases Regulatory phrase (List of promoters regulated by the phrase)

Transcription factor regulation    

Transcription factor binding sites (TFBSs) arrangements

  Functional conformation Function Promoter Sigma factor Central Rel-Pos Distance to first Gene Genes Sequence LeftPos RightPos Evidence Confidence level (C: Confirmed, S: Strong, W: Weak) References
  YeiL activator yeiLp Sigma38 nd nd yeiL nd nd [EXP-IEP-GENE-EXPRESSION-ANALYSIS] W [1], [1]

Evolutionary conservation of regulatory elements    
     Note: Evolutionary conservation of regulatory interactions and promoters is limited to gammaproteobacteria.
Promoter-target gene evolutionary conservation