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Synonyms: PlaR |
Summary:
YiaJ is a transcriptional repressor that negatively controls the expression of genes involved in the catabolism of the rare pentose L-lyxose [1, 2, 3] YiaJ was confirmed as a TF through an integrated workflow comprised of computational prediction, knowledge-based classification, and experimental validation of candidate TFs at the genome scale [4]. YiaJ regulates genes that are responsible for utilization of L-ascorbate [4, 5].Accordingly, YiaJ is involved in utilization control of other plant-derived nutrients, such as galacturonate from plant pectin, sorbitol (sugar alcohol) in many edible fruits, and fructose and its Maillard reaction product (fructose-lysine) in many vegetables. YiaJ also controls the expression of a number of genes for survival of E. coli K-12 under stressful conditions in nature. Based on these roles, it was proposed to rename YiaJ as PlaR (regulator of plant utilization) [5]. When wild-type E. Read more > |
Transcription factor | ![]() ![]() |
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TF conformation(s): |
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Evolutionary Family: | IclR | ||||||||||||
Connectivity class: | Local Regulator | ||||||||||||
Gene name: | plaR | ||||||||||||
Genome position: | 3741684-3742532 | ||||||||||||
Length: | 849 bp / 282 aa | ||||||||||||
Operon name: | plaR | ||||||||||||
TU(s) encoding the TF: |
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Regulon |
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Regulated gene(s) | lyxK, plaR, sgbE, sgbH, sgbU, yiaK, yiaL, yiaM, yiaN, yiaO | ||||||
Multifun term(s) of regulated gene(s) |
MultiFun Term (List of genes associated to the multifun term)
carbon compounds (4)
Porters (Uni-, Sym- and Antiporters) (3)
membrane (2)
Transcription related (1)
repressor (1)
Read more >
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Regulated operon(s) | plaR, yiaKLMNO-lyxK-sgbHUE | ||||||
First gene in the operon(s) | plaR, yiaK | ||||||
Simple and complex regulons | CRP,IHF,PlaR | ||||||
Simple and complex regulatory phrases | Regulatory phrase (List of promoters regulated by the phrase) |
Transcription factor regulation |
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Functional conformation | Function | Promoter | Sigma factor | Central Rel-Pos | Distance to first Gene | Genes | Sequence | LeftPos | RightPos | Evidence (Confirmed, Strong, Weak) | References | |
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PlaR | repressor | plaRp | Sigma70 | -55.0 | -141.0 | plaR |
aaatttcaatATGCGAAACTTGATTTCAAATatatcgatca
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3742663 | 3742683 | [GEA], [BCE] | [1] | |
PlaR | repressor | yiaKp | Sigma70 | -1.0 | -60.0 | yiaK, yiaL, yiaM, yiaN, yiaO, lyxK, sgbH, sgbU, sgbE |
tgatcgatatATTTGAAATCAAGTTTCGCATattgaaattt
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3742663 | 3742683 | [GEA], [BCE] | [1] |
Evolutionary conservation of regulatory elements | ![]() |
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Reference(s) |
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