RegulonDB RegulonDB 10.9:Regulon Page

DicA DNA-binding transcriptional repressor

Synonyms: DicA
The transcription factor DicA, "Division control," is a temperature-sensitive repressor that controls the transcription of genes involved in the cell division process [2, 4] and activation of its own expression [3]. Nevertheless, the signal to which DicA responds is still unknown. The family to which DicA belongs has not been established; it is a protein of 15 kDa with a hypothetical DNA-binding domain in the N-terminal domain []. DicA is homologous in structure and function to RovA (Yersinia) and SlyA (Salmonella), both of which are activators for pathogenicity-related genes [3].

Transcription factor      
TF conformation(s):
Name Conformation Type TF-Effector Interaction Type Apo/Holo Conformation Evidence (Confirmed, Strong, Weak) References
DicA Functional   [APPHINH], [HIFS], [IEP], [IFC] [1], [2], [3]
Evolutionary Family: HTH_3
Connectivity class: Local Regulator
Gene name: dicA
  Genome position: 1647934-1648341
  Length: 408 bp / 135 aa
Operon name: dicA
TU(s) encoding the TF:
Transcription unit        Promoter

Regulated gene(s) dicB, dicC, insD7, intQ, ydfD, ydfE, ydfW, ydfX
Multifun term(s) of regulated gene(s) MultiFun Term (List of genes associated to the multifun term)
prophage genes and phage related functions (7)
cell cycle physiology (1)
Regulated operon(s) dicB-ydfDE-insD7-intQ, dicC-ydfXW
First gene in the operon(s) dicB, dicC
Simple and complex regulons DicA
Simple and complex regulatory phrases Regulatory phrase (List of promoters regulated by the phrase)

Transcription factor regulation    

Transcription factor binding sites (TFBSs) arrangements

  Functional conformation Function Promoter Sigma factor Central Rel-Pos Distance to first Gene Genes Sequence LeftPos RightPos Evidence (Confirmed, Strong, Weak) References
  DicA repressor dicBp Sigma70 nd nd dicB, ydfD, ydfE, insD7, intQ nd nd [BPP], [GEA], [IGI] [4]
  DicA repressor dicCp Sigma70 2.5 -24.5 dicC, ydfX, ydfW
1647865 1647885 [BPP], [GEA], [IHBCE] [3]

High-throughput Transcription factor binding sites (TFBSs)

  Functional conformation Function Object name Object type Distance to first Gene Sequence LeftPos RightPos Center Position Growth Condition Evidence (Confirmed, Strong, Weak) References
  DicA activator dicA Transcription-Unit nd
1647865 1647885 1647874.5 nd [BPP], [GEA], [IHBCE] [3]

Evolutionary conservation of regulatory elements    
     Note: Evolutionary conservation of regulatory interactions and promoters is limited to gammaproteobacteria.
Promoter-target gene evolutionary conservation