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SgrR DNA-binding transcriptional dual regulator

Synonyms: SgrR
"SugaR transport-related Regulator" SgrR is negatively autoregulated and coordinately activates transcription of the divergent operon. This regulator coordinates the response to glucose-phosphate stress [1, 2]. As the intracellular accumulation of glucose-6-phosphate correlates with SgrR induction, it has been proposed as its inducer [1, 2]. Autoregulation of SgrR is not affected by phosphosugar stress [2]. In addition, the induction of sgrS expression by the nonmetabolizable glucose PTS substrate (+/-)-methyl glucoside is abolished in a sgrR mutant [1]. The SgrR protein is a member of a novel family of regulators and contains an N terminal which is characteristic of winged-helix DNA-binding transcriptional regulators and a predicted C-terminal solute-binding domain [2]. Inhibition in vivo of SgrR by glutamate has been shown [] Read more >

Transcription factor      
TF conformation(s):
Name Conformation Type TF-Effector Interaction Type Apo/Holo Conformation Evidence (Confirmed, Strong, Weak) References
SgrR Functional   [IMP] [1]
Evolutionary Family: MarR
Connectivity class: Local Regulator
Gene name: sgrR
  Genome position: 75644-77299
  Length: 1656 bp / 551 aa
Operon name: sgrR-sroA-thiBPQ
TU(s) encoding the TF:
Transcription unit        Promoter

Regulated gene(s) alaC, setA, sgrR, sgrS, sgrT, sroA, thiB, thiP, thiQ
Multifun term(s) of regulated gene(s) MultiFun Term (List of genes associated to the multifun term)
thiamin (3)
membrane (2)
alanine (1)
Electrochemical potential driven transporters (1)
other (mechanical, nutritional, oxidative stress) (1)
Read more >
Regulated operon(s) alaC, sgrR-sroA-thiBPQ, sgrST-setA
First gene in the operon(s) alaC, sgrR, sgrS
Simple and complex regulons Cra,DksA,SgrR,ppGpp
Simple and complex regulatory phrases Regulatory phrase (List of promoters regulated by the phrase)

Transcription factor regulation    

Transcription factor binding sites (TFBSs) arrangements

  Functional conformation Function Promoter Sigma factor Central Rel-Pos Distance to first Gene Genes Sequence LeftPos RightPos Evidence (Confirmed, Strong, Weak) References
  SgrR activator alaCp Sigma70 -167.5 -271.5 alaC
2498550 2498583 [APIORCISFBSCS], [GEA], [SM] [2]
  SgrR repressor sgrRp Sigma70 25.5 -14.5 sgrR, sroA, thiB, thiP, thiQ
77297 77330 [APIORCISFBSCS], [BPP], [GEA], [SM] [1], [2]
  SgrR activator sgrSp Sigma70 -53.5 -53.5 sgrS, sgrT, setA
77297 77330 [APIORCISFBSCS], [BPP], [GEA], [SM] [1], [2], [3]
  SgrR activator sgrSp2 Sigma38 -53.5 -53.5 sgrS, sgrT, setA
77297 77330 [APIORCISFBSCS], [BPP], [GEA], [SM] [1], [2], [3]

Evolutionary conservation of regulatory elements    
     Note: Evolutionary conservation of regulatory interactions and promoters is limited to gammaproteobacteria.
Promoter-target gene evolutionary conservation