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CreB DNA-binding transcriptional dual regulator

Synonyms: CreB-Phosphorylated, CreB
Summary:
CreB "Carbon source responsive response regulator," is a DNA-binding transcriptional dual regulator [2, 3] and belongs to the CreBC two-component system (TCS) [2, 3], which controls genes involved in acetate [4] and ribose [] metabolism, in the maltose regulon [5], in the pentose phosphate pathway [], and genes which repair DNA damage associated with the replication fork [6]. CreBC regulates the expression of cre regulon genes in response to a switch from complex to minimal medium [2].
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Transcription factor      
TF conformation(s):
Name Conformation Type TF-Effector Interaction Type Apo/Holo Conformation Evidence (Confirmed, Strong, Weak) References
CreB Non-Functional   Apo [BPP], [IPI] [1]
CreB-Phosphorylated Functional Covalent Holo [AIFS], [APPH], [BPP], [IEP], [IPI] [1], [2], [3]
Evolutionary Family: OmpR
Sensing class: External-Two-component systems
Connectivity class: Local Regulator
Gene name: creB
  Genome position: 4636007-4636696
  Length: 690 bp / 229 aa
Operon name: creABCD
TU(s) encoding the TF:
Transcription unit        Promoter
creABC
creAp2
creABCD
creAp


Regulon       
Regulated gene(s) creD, malE, malF, malG, talA
Multifun term(s) of regulated gene(s) MultiFun Term (List of genes associated to the multifun term)
membrane (3)
carbon compounds (2)
ABC superfamily, membrane component (2)
ABC superfamily, periplasmic binding component (1)
motility, chemotaxis, energytaxis (aerotaxis, redoxtaxis etc) (1)
Regulated operon(s) creABCD, malEFG, talA-tktB
First gene in the operon(s) creD, malE, talA
Simple and complex regulons CRP,CreB,Fis,H-NS,MalT,StpA
CreB
Simple and complex regulatory phrases Regulatory phrase (List of promoters regulated by the phrase)
[CreB,-](1)
[CreB,+](2)


Transcription factor regulation    


Transcription factor binding sites (TFBSs) arrangements
      

  Functional conformation Function Promoter Sigma factor Central Rel-Pos Distance to first Gene Genes Sequence
LeftPos RightPos Evidence (Confirmed, Strong, Weak) References
  CreB-Phosphorylated activator creDp nd -52.5 -70.5 creD
cctcgcttcgACTTCACCGTCACTTCACAtagcttcaaa
4638099 4638117 [AIBSCS], [BPP], [GEA] [2], [3]
  CreB-Phosphorylated repressor malEp Sigma70 18.5 -27.5 malE, malF, malG
ccgtttaggtGTTTTCACGAGCACTTCACcaacaaggac
4246438 4246456 [AIBSCS], [GEA] [2]
  CreB-Phosphorylated activator talAp nd -211.5 -269.5 talA
ttggttgttcCTTTCACGTAACGTTCACAaataaagtgt
2578388 2578406 [AIBSCS], [GEA] [2]



High-throughput Transcription factor binding sites (TFBSs)
      

  Functional conformation Function Object name Object type Distance to first Gene Sequence LeftPos RightPos Center Position Growth Condition Evidence (Confirmed, Strong, Weak) References
  CreB-Phosphorylated activator recG Transcription-Unit nd
nd
nd nd nd nd [BPP], [GEA], [IGI] [2]
  CreB-Phosphorylated activator nudF-yqiB-cpdA-yqiA-parE Transcription-Unit nd
nd
nd nd nd nd [BPP], [GEA], [IGI] [2]
  CreB-Phosphorylated activator ackA-pta Transcription-Unit nd
nd
nd nd nd nd [BPP], [GEA], [IGI] [2]
  CreB-Phosphorylated activator cbrB Transcription-Unit nd
nd
nd nd nd nd [BPP], [GEA], [IGI] [2]
  CreB-Phosphorylated activator cbrA Transcription-Unit nd
nd
nd nd nd nd [BPP], [GEA], [IGI] [2]


Evolutionary conservation of regulatory elements    
     Note: Evolutionary conservation of regulatory interactions and promoters is limited to gammaproteobacteria.
Promoter-target gene evolutionary conservation






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