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EnvR DNA-binding transcriptional repressor

Synonyms: EnvR
EnvR, also known as AcrS, represses the transcription of genes encoding a drug efflux pump that has a role in resistance to antibiotics [1] This protein is homologous to some other proteins, such as MtrR of Neisseria gonorrhoeae, TcmR of Streptomyces glaucescens, JadR2 from Streptomyces venezuelae, and AcrR from Escherichia coli [2, 3] All of these proteins, including EnvR, have a helix-turn-helix motif close to the N terminus [2, 3] EnvR recognizes and binds a 24-bp palindromic DNA sequence [1] The same sequence is also recognized by the transcriptional repressor AcrR [1] envR is adjacent and divergent in the genome to acrEF, an operon that encodes another drug efflux pump; however, it is not regulated or is only lightly affected by EnvR [1] Both of these transcription units appears to be repressed by HNS [1] Based on wide-scale analyses, the conservation of the TetR-family transcriptional regulators (TFTRs) across two genera, Escherichia and Salmonella, were analyzed and compared on three levels: genus, species, and strain.
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Transcription factor      
TF conformation(s):
Name Conformation Type TF-Effector Interaction Type Apo/Holo Conformation Evidence (Confirmed, Strong, Weak) References
EnvR Functional   nd nd
Evolutionary Family: TetR/AcrR
Connectivity class: Local Regulator
Gene name: envR
  Genome position: 3412803-3413465
  Length: 663 bp / 220 aa
Operon name: envR
TU(s) encoding the TF:
Transcription unit        Promoter

Regulated gene(s) acrA, acrB
Multifun term(s) of regulated gene(s) MultiFun Term (List of genes associated to the multifun term)
drug resistance/sensitivity (2)
membrane (2)
Porters (Uni-, Sym- and Antiporters) (1)
Electrochemical potential driven transporters (1)
Regulated operon(s) acrAB
First gene in the operon(s) acrA
Simple and complex regulons AcrR,EnvR,MarA,MprA,PhoP,Rob,SoxS
Simple and complex regulatory phrases Regulatory phrase (List of promoters regulated by the phrase)

Transcription factor regulation    

Transcription factor binding sites (TFBSs) arrangements

  Functional conformation Function Promoter Sigma factor Central Rel-Pos Distance to first Gene Genes Sequence LeftPos RightPos Evidence (Confirmed, Strong, Weak) References
  EnvR repressor acrAp Sigma70 -22.5 -101.5 acrA, acrB
485709 485732 [GEA], [AIBSCS], [BPP] [1]

Evolutionary conservation of regulatory elements    
     Note: Evolutionary conservation of regulatory interactions and promoters is limited to gammaproteobacteria.
Promoter-target gene evolutionary conservation