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Synonyms: MazE |
Summary:
MazE is an antitoxin that counteracts the MazF toxin [2, 3]. MazF exhibits ribonuclease activity toward single stranded RNA regions of sequence ACA, and the resulting degradation of cellular mRNA causes global translation inhibition [4]. MazF exhibits RNase activity toward tmRNA, and tmRNA is involved in release of MazF-mediated cell growth inhibition [5]. The mazEF system causes a "programmed cell death" response to stresses including starvation [3] and antibiotics [6]. The antitoxin, MazE, is subject to degradation by the ClpAP protease complex and exhibits a short (30 minute) half life, whereas the toxin, MazF, is much more stable [3]. Read more > |
Transcription factor | ![]() ![]() |
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TF conformation(s): |
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Evolutionary Family: | MazE | ||||||||||||
Connectivity class: | Local Regulator | ||||||||||||
Gene name: | mazE | ||||||||||||
Genome position: | 2911091-2911339 | ||||||||||||
Length: | 249 bp / 82 aa | ||||||||||||
Operon name: | relA-mazEFG | ||||||||||||
TU(s) encoding the TF: |
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Regulon |
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Regulated gene(s) | mazE, mazF, mazG | ||||||
Multifun term(s) of regulated gene(s) |
MultiFun Term (List of genes associated to the multifun term)
starvation (3)
defense/survival (2)
other (mechanical, nutritional, oxidative stress) (2)
cell killing (2)
drug resistance/sensitivity (2)
Read more >
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Regulated operon(s) | relA-mazEFG | ||||||
First gene in the operon(s) | mazE | ||||||
Simple and complex regulons | Fis,MazE,MazE-MazF Fis,MazE,MazE-MazF,ppGpp | ||||||
Simple and complex regulatory phrases | Regulatory phrase (List of promoters regulated by the phrase) |
Transcription factor regulation |
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Functional conformation | Function | Promoter | Sigma factor | Central Rel-Pos | Distance to first Gene | Genes | Sequence | LeftPos | RightPos | Evidence (Confirmed, Strong, Weak) | References | |
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MazE | repressor | mazEp1 | nd | -21.0 | -50.0 | mazE, mazF, mazG |
gaaatttgctCGTATCTACAATGTAGATTGATATATACtgtatctaca
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2911376 | 2911403 | [BCE], [GEA], [SM], [BCE], [SM] | [1] | |
MazE | repressor | mazEp1 | nd | -7.0 | -36.0 | mazE, mazF, mazG |
ctacaatgtaGATTGATATATACTGTATCTACATATgatagcggtt
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2911363 | 2911388 | [BCE], [GEA], [SM], [BCE], [SM] | [1] | |
MazE | repressor | mazEp2 | nd | -34.0 | -50.0 | mazE, mazF, mazG |
gaaatttgctCGTATCTACAATGTAGATTGATATATACtgtatctaca
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2911376 | 2911403 | [GEA], [BCE], [SM] | [1] | |
MazE | repressor | mazEp2 | nd | -20.0 | -36.0 | mazE, mazF, mazG |
ctacaatgtaGATTGATATATACTGTATCTACATATgatagcggtt
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2911363 | 2911388 | [GEA], [BCE], [SM] | [1] |
Evolutionary conservation of regulatory elements | ![]() |
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Reference(s) |
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