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MazE DNA-binding transcriptional repressor

Synonyms: MazE
Summary:
MazE is an antitoxin that counteracts the MazF toxin [2, 3]. MazF exhibits ribonuclease activity toward single stranded RNA regions of sequence ACA, and the resulting degradation of cellular mRNA causes global translation inhibition []. MazF exhibits RNase activity toward tmRNA, and tmRNA is involved in release of MazF-mediated cell growth inhibition []. The mazEF system causes a "programmed cell death" response to stresses including starvation [3] and antibiotics []. The antitoxin, MazE, is subject to degradation by the ClpAP protease complex and exhibits a short (30 minute) half life, whereas the toxin, MazF, is much more stable [3].
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Transcription factor      
TF conformation(s):
Name Conformation Type TF-Effector Interaction Type Apo/Holo Conformation Evidence (Confirmed, Strong, Weak) References
MazE Functional   nd nd
Evolutionary Family: MazE
Connectivity class: Local Regulator
Gene name: mazE
  Genome position: 2911091-2911339
  Length: 249 bp / 82 aa
Operon name: relA-mazEFG
TU(s) encoding the TF:
Transcription unit        Promoter
mazEFG
mazEp1
mazEFG
mazEp2
relA-mazEF
relAp1
relA-mazEF
relAp2


Regulon       
Regulated gene(s) mazE, mazF, mazG
Multifun term(s) of regulated gene(s) MultiFun Term (List of genes associated to the multifun term)
starvation (3)
defense/survival (2)
other (mechanical, nutritional, oxidative stress) (2)
cell killing (2)
drug resistance/sensitivity (2)
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Regulated operon(s) relA-mazEFG
First gene in the operon(s) mazE
Simple and complex regulons Fis,MazE,MazE-MazF
Fis,MazE,MazE-MazF,ppGpp
Simple and complex regulatory phrases Regulatory phrase (List of promoters regulated by the phrase)
[MazE,-](2)


Transcription factor regulation    


Transcription factor binding sites (TFBSs) arrangements
      

  Functional conformation Function Promoter Sigma factor Central Rel-Pos Distance to first Gene Genes Sequence LeftPos RightPos Evidence (Confirmed, Strong, Weak) References
  MazE repressor mazEp1 nd -21.0 -50.0 mazE, mazF, mazG
gaaatttgctCGTATCTACAATGTAGATTGATATATACtgtatctaca
2911376 2911403 [BCE], [GEA], [SM], [BCE], [GEA], [SM] [1]
  MazE repressor mazEp1 nd -7.0 -36.0 mazE, mazF, mazG
ctacaatgtaGATTGATATATACTGTATCTACATATgatagcggtt
2911363 2911388 [BCE], [GEA], [SM], [BCE], [GEA], [SM] [1]
  MazE repressor mazEp2 nd -34.0 -50.0 mazE, mazF, mazG
gaaatttgctCGTATCTACAATGTAGATTGATATATACtgtatctaca
2911376 2911403 [BCE], [GEA], [SM] [1]
  MazE repressor mazEp2 nd -20.0 -36.0 mazE, mazF, mazG
ctacaatgtaGATTGATATATACTGTATCTACATATgatagcggtt
2911363 2911388 [BCE], [GEA], [SM] [1]


Evolutionary conservation of regulatory elements    
     Note: Evolutionary conservation of regulatory interactions and promoters is limited to gammaproteobacteria.
Promoter-target gene evolutionary conservation






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