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MatA DNA-binding transcriptional dual regulator

Synonyms: MatA
Summary:
MatA is a LuxR-type transcription factor that is directly involved, as a positive regulator acting at transcriptional and posttranscriptional levels, in the expression of the mat operon in meningitis isolate strain IHE 3034 (T. A. Lehti, P. Bauchart, M. Kukkonen, U. Dobrindt, T. K. Korhonen, B. Westerlund-Wikström, unpublished results) [1]. On the other hand, MatA controls the expression of the flhDC operon, with higher affinity to flhDp, repressing flagellum biosynthesis, motility, and taxis [1]. The opposite regulatory actions of MatA on mat and on flhDC promoters advance the adaptation of E. coli from a planktonic to an adhesive lifestyle [1]. MatA binds more weakly to pfliA and to pfliC, and their levels are equal to those observed for matB [1]. MatA exerts a dual regulatory function on the choice of planktonic/sessile lifestyle and further supports the presence of antagonistic control of attachment and motility.
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Transcription factor      
TF conformation(s):
Name Conformation Type TF-Effector Interaction Type Apo/Holo Conformation Evidence Confidence level (C: Confirmed, S: Strong, W: Weak) References
MatA Functional   nd nd nd
Evolutionary Family: LuxR/UhpA
TFBs symmetry: inverted-repeat
Connectivity class: Local Regulator
Gene name: matA
  Genome position: 310746-311336
  Length: 591 bp / 196 aa
Operon name: matA
TU(s) encoding the TF:
Transcription unit        Promoter
ecpR
ecpRp


Regulon       
Regulated gene(s) ecpA, flhC, flhD, fliA, fliC, fliX, fliZ, matA, tcyJ
Multifun term(s) of regulated gene(s) MultiFun Term (List of genes associated to the multifun term)
motility, chemotaxis, energytaxis (aerotaxis, redoxtaxis etc) (4)
flagella (4)
flagellum (3)
Transcription related (3)
activator (2)
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Regulated operon(s) ecpA, flhDC, fliAZ-tcyJ, fliCX, matA
First gene in the operon(s) ecpA, matA, flhD, fliA, fliC
Simple and complex regulons AcrR,CRP,FliZ,Fur,H-NS,HdfR,IHF,LrhA,MatA,OmpR,QseB,RcsAB,YjjQ
CsgD,FlhDC,H-NS,IHF,MatA,NsrR,SutR
GadE,H-NS,MatA
MatA
Simple and complex regulatory phrases Regulatory phrase (List of promoters regulated by the phrase)
[MatA,-](4)
[MatA,+](2)


Transcription factor regulation    


Transcription factor binding sites (TFBSs) arrangements
      


Evolutionary conservation of regulatory elements    
     Note: Evolutionary conservation of regulatory interactions and promoters is limited to gammaproteobacteria.
Promoter-target gene evolutionary conservation






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