RegulonDB RegulonDB 11.1:Regulon Page

RspR DNA-binding transcriptional repressor

Synonyms: RspR
YdfH belongs to the GntR transcription factor family [3], for which the consensus sequence is reported to be tnGTnnnACna [4]. Although only one site was determined in a gel shift assay, it is possible that YfdH binds as a complex of flanking regions of the core sequence (-65 to -50) [1]. It was determined by Genomic SELEX screening that a site located upstream of rspAB is the only target of RspR [2].

Transcription factor      
TF conformation(s):
Name Conformation Type TF-Effector Interaction Type Apo/Holo Conformation Evidence Confidence level (C: Confirmed, S: Strong, W: Weak) References
RspR Functional   nd nd nd
Evolutionary Family: GntR
TFBs symmetry: inverted-repeat
Connectivity class: Local Regulator
Gene name: rspR
  Genome position: 1628352-1629038
  Length: 687 bp / 228 aa
Operon name: rspR
TU(s) encoding the TF:
Transcription unit        Promoter

Regulated gene(s) rspA, rspB
Multifun term(s) of regulated gene(s)
starvation (2)
Regulated operon(s) rspAB
First gene in the operon(s) rspA
Simple and complex regulons CRP,RspR
Simple and complex regulatory phrases Regulatory phrase (List of promoters regulated by the phrase)

Transcription factor regulation    

Transcription factor binding sites (TFBSs) arrangements

  Functional conformation Function Promoter Sigma factor Central Rel-Pos Distance to first Gene Genes Sequence LeftPos RightPos Evidence Confidence level (C: Confirmed, S: Strong, W: Weak) References
  RspR repressor rspAp nd -35.0 -65.0 rspA, rspB

Evolutionary conservation of regulatory elements    
     Note: Evolutionary conservation of regulatory interactions and promoters is limited to gammaproteobacteria.
Promoter-target gene evolutionary conservation