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Synonyms: DinJ-YafQ |
Summary:
The YafQ-DinJ toxin-antitoxin system was identified by its similarity to the RelE-RelB toxin-antitoxin system [3]. Expression of YafQ alone reduces protein synthesis and inhibits growth, and coexpression of DinJ alleviates that phenotype, acting as the antitoxin [2, 4, 5]. YafQ and DinJ form a stable complex [4] which can bind to the dinJ-yafQ palindrome upstream of the translation start site [2]. A strain from which all five toxin-antitoxin systems have been deleted shows no deficiency in its stress response or competitiveness under nutrient-limited conditions [6]. However, biofilm formation is affected via expression of the TabA protein [7]. Read more > |
Transcription factor | ![]() ![]() |
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TF conformation(s): |
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TFBs length: | 16 | ||||||||||||||
TFBs symmetry: | inverted-repeat | ||||||||||||||
Connectivity class: | Local Regulator | ||||||||||||||
Gene name: | dinJ | ||||||||||||||
Genome position: | 246242-246502 | ||||||||||||||
Length: | 261 bp / 86 aa | ||||||||||||||
Operon name: | dinJ-yafQ | ||||||||||||||
TU(s) encoding the TF: |
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Gene name: | yafQ | ||||||||||||||
Genome position: | 245961-246239 | ||||||||||||||
Length: | 279 bp / 92 aa | ||||||||||||||
Operon name: | dinJ-yafQ | ||||||||||||||
TU(s) encoding the TF: |
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Regulon |
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Regulated gene(s) | cspE, dinJ, yafQ | ||||||
Multifun term(s) of regulated gene(s) |
MultiFun Term (List of genes associated to the multifun term)
cell killing (2)
transcriptional level (1)
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Regulated operon(s) | cspE, dinJ-yafQ | ||||||
First gene in the operon(s) | cspE, dinJ | ||||||
Simple and complex regulons | DinJ-YafQ DinJ-YafQ,LexA | ||||||
Simple and complex regulatory phrases | Regulatory phrase (List of promoters regulated by the phrase) |
Transcription factor regulation |
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Functional conformation | Function | Promoter | Sigma factor | Central Rel-Pos | Distance to first Gene | Genes | Sequence | LeftPos | RightPos | Evidence | Confidence level (C: Confirmed, S: Strong, W: Weak) | References | |
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DinJ-YafQ | repressor | cspEp1 | Sigma70 | -43.5 | -188.5 | cspE |
tgtactttgcCTGGATGCGCTTTCAGTtttgagacaa
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657096 | 657112 | [EXP-IEP-GENE-EXPRESSION-ANALYSIS], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS], [EXP-IMP-SITE-MUTATION] | C | [1] | |
DinJ-YafQ | repressor | dinJp | Sigma70 | 89.5 | -24.5 | dinJ, yafQ |
tacaattcaaGCTGAATAAATATACAGcacaggagat
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246519 | 246535 | [COMP-HINF-SIMILAR-TO-CONSENSUS], [EXP-IDA-BINDING-OF-PURIFIED-PROTEINS], [EXP-IMP-SITE-MUTATION] | C | [2] |
Evolutionary conservation of regulatory elements | ![]() |
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Reference(s) |
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