RegulonDB RegulonDB 11.0:Regulon Page

FrlR DNA-binding transcriptional repressor

Synonyms: FrlR, FrlR-N6-(1-deoxy-6-O-phospho-D-fructos-1-yl)-L-lysine
As a dimer, FrlR binds DNA to regulate transcription, and it becomes inactive as a regulator when it is bound to fructoselysine-6-phosphate [1]. It has a winged helix-turn-helix domain for binding DNA, and this domain contains the amino acids Arg49, Gly70, and Lys71, which appear to be essential for DNA binding [1]. FrlR has similarity to Bacillus subtilis FrlR [1, 2], B. subtilis NagR [1], and S. enterica FraR [1]. As homologues, this protein appears to pertain to the GntR/HutC family of transcriptional regulators [1]. FrlR: fructolysine [2] Read more >

Transcription factor      
TF conformation(s):
Name Conformation Type TF-Effector Interaction Type Apo/Holo Conformation Evidence (Confirmed, Strong, Weak) References
FrlR Functional   nd nd
FrlR-N6-(1-deoxy-6-O-phospho-D-fructos-1-yl)-L-lysine Non-Functional   nd nd
TFBs length: 10
Connectivity class: Local Regulator
Gene name: frlR
  Genome position: 3504052-3504783
  Length: 732 bp / 243 aa
Operon name: frlABCDR
TU(s) encoding the TF:
Transcription unit        Promoter

Regulated gene(s) frlA, frlB, frlC, frlD, frlR
Multifun term(s) of regulated gene(s) MultiFun Term (List of genes associated to the multifun term)
carbon compounds (3)
Porters (Uni-, Sym- and Antiporters) (1)
membrane (1)
Transcription related (1)
repressor (1)
Regulated operon(s) frlABCDR
First gene in the operon(s) frlA
Simple and complex regulons CRP,FrlR
Simple and complex regulatory phrases Regulatory phrase (List of promoters regulated by the phrase)

Transcription factor regulation    

Transcription factor binding sites (TFBSs) arrangements

  Functional conformation Function Promoter Sigma factor Central Rel-Pos Distance to first Gene Genes Sequence LeftPos RightPos Evidence (Confirmed, Strong, Weak) References
  FrlR repressor frlAp1 Sigma70 12.5 -63.5 frlA, frlB, frlC, frlD, frlR
3499842 3499851 [GEA], [APIORCISFBSCS], [BPP], [SM] [1]

Evolutionary conservation of regulatory elements    
     Note: Evolutionary conservation of regulatory interactions and promoters is limited to gammaproteobacteria.
Promoter-target gene evolutionary conservation