RegulonDB RegulonDB 10.8: Regulon Form
   
   


DksA,DksA-ppGpp,Fis,Lrp,ppGpp regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
Fis Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class TFs for DNA-bending
Synonym(s): DNA-binding transcriptional dual regulator Fis, Nbp, site-specific DNA inversion stimulation factor
Gene name(s): fis
Functional conformation(s): Fis
Coregulator(s): AcrR, AdiY, AppY, ArcA, ArgP, BasR, CRP, CpxR, Cra, CreB, CspA, CusR, CytR, DeoR, DksA, DksA-ppGpp, DnaA, FNR, FadR, Fis, FlhDC, FliZ, Fur, GadE, GadE-RcsB, GadW, GadX, GlcC, GlpR, H-NS, HprR, IHF, IscR, LeuO, Lrp, MalT, MarA, MarR, MazE, MazE-MazF, Mlc, MntR, ModE, NanR, NarL, NarP, NrdR, NsrR, NtrC, OmpR, OxyR, PdhR, PepA, PurR, RcsB, RcsB-BglJ, Rob, RstA, RutR, SlyA, SoxS, StpA, TorR, XylR, YdeO, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
Lrp Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class Sensing external and internal signals
Synonym(s): AlsB, DNA-binding transcriptional dual regulator Lrp, Ihb, LivR, Lrs, Lss, LstR, Mbf, OppI, RblA
Gene name(s): lrp
Functional conformation(s): Lrp-leucine , Lrp
Coregulator(s): AcrR, Ada, AdiY, AidB, ArcA, ArgP, ArgR, CRP, CadC, CpxR, Cra, DksA, DksA-ppGpp, EnvY, FNR, Fis, FliZ, Fur, GadE, GadE-RcsB, GadW, GadX, GcvA, GlaR, H-NS, HU, HdfR, IHF, LrhA, Lrp, MarA, Mlc, ModE, Nac, NarL, NhaR, NsrR, OmpR, PhoP, PurR, QseB, RcsB, Rob, SoxS, StpA, TorR, YeiL, YjjQ, ppGpp
Summary: TF Summary ...[more]

REGULATION EXERTED BY DksA,DksA-ppGpp,Fis,Lrp,ppGpp Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
DksA inhibition DksA-ppGpp inhibition Fis activator Lrp repressor ppGpp inhibition    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
Fis activator rrsAp1 rrsA , ileT , alaT , rrlA , rrfA 4035099 4035113 -133.0 gggagcaggtGGCGAATTTCGCCCGagaaatcgcc [BPP]
[GEA]
[1]
Fis activator rrsAp1 rrsA , ileT , alaT , rrlA , rrfA 4035121 4035135 -111.0 ccgagaaatcGCCCATTTAACCGACaaaccgacgc [BPP]
[GEA]
[1]
Fis activator rrsAp1 rrsA , ileT , alaT , rrlA , rrfA 4035141 4035155 -91.0 ccgacaaaccGACGCTGAAATAAGCataaagaata [BPP]
[GEA]
[1]
Fis activator rrsAp1 rrsA , ileT , alaT , rrlA , rrfA 4035161 4035175 -71.0 taagcataaaGAATAAAAAATGCGCggtcagaaaa [BPP] [1]
Fis activator rrsEp rrsE , gltV , rrlE , rrfE 4207686 4207700 -170.0 tttcaatggtGATCACAATTTTGACtgtggttacc [BPP]
[GEA]
[1]
Fis activator rrsEp rrsE , gltV , rrlE , rrfE 4207713 4207727 -143.0 tggttaccgtGGGCAAAATACAGAAattacattga [BPP]
[GEA]
[1]
Fis activator rrsEp rrsE , gltV , rrlE , rrfE 4207739 4207753 -117.0 ttacattgatGATTGTGGATAACTCtgtgcgtaaa [BPP]
[GEA]
[1]
Fis activator rrsEp rrsE , gltV , rrlE , rrfE 4207755 4207769 -101.0 ggataactctGTGCGTAAAAAGGTAtaaagcgggc [BPP]
[GEA]
[1]
Fis activator rrsEp rrsE , gltV , rrlE , rrfE 4207784 4207798 -72.0 gcgggcttttGCTGGGGAATGCAGCagtcagtcat [BPP]
[GEA]
[1]
Lrp-leucine repressor rrsAp1 rrsA , ileT , alaT , rrlA , rrfA 4035160 4035171 -73.0 ataagcataaAGAATAAAAAATgcgcggtcag [BCE] [2]
Lrp-leucine repressor rrsAp1 rrsA , ileT , alaT , rrlA , rrfA 4035180 4035191 -53.0 atgcgcggtcAGAAAATTATTTtaaatttcct [BPP] [2]
Lrp-leucine repressor rrsEp rrsE , gltV , rrlE , rrfE         [GEA] [2]

Evidence: [BPP] Binding of purified proteins
[GEA] Gene expression analysis
[BCE] Binding of cellular extracts
Reference(s): [1] Hirvonen CA., et al., 2001
[2] Pul U., et al., 2005



Reference(s)    

 [1] Hirvonen CA., Ross W., Wozniak CE., Marasco E., Anthony JR., Aiyar SE., Newburn VH., Gourse RL., 2001, Contributions of UP elements and the transcription factor FIS to expression from the seven rrn P1 promoters in Escherichia coli., J Bacteriol 183(21):6305-14

 [2] Pul U., Wurm R., Lux B., Meltzer M., Menzel A., Wagner R., 2005, LRP and H-NS--cooperative partners for transcription regulation at Escherichia coli rRNA promoters., Mol Microbiol 58(3):864-76


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