RegulonDB RegulonDB 10.8: Regulon Form
   
   


IHF,PspF regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
PspF      Tractordb tool
Connectivity class Local Regulator
Synonym(s): DNA-binding transcriptional dual regulator PspF, YcjB
Gene name(s): pspF
Functional conformation(s): PspF
Coregulator(s): IHF, PspF
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
IHF Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class TFs for DNA-bending
Synonym(s): DNA-binding transcriptional dual regulator IHF
Gene name(s): ihfB, ihfA
Functional conformation(s): IHF
Coregulator(s): AcrR, AdiY, ArcA, ArgR, AtoC, BasR, BtsR, CRP, Cbl, CpxR, Cra, CsgD, CysB, DksA, DksA-ppGpp, EnvY, FNR, FadR, FhlA, Fis, FlhDC, FliZ, Fur, GadE, GlcC, GlpR, GlrR, H-NS, HU, HdfR, HipAB, HipB, IHF, IclR, IscR, LrhA, Lrp, MarA, MatA, MlrA, MntR, ModE, MprA, MqsA, Nac, NagC, NanR, NarL, NarP, NorR, NsrR, NtrC, OmpR, OxyR, PaaX, PdhR, PepA, PhoB, PspF, PurR, QseB, RcdA, RcsAB, Rob, RstA, RtcR, RutR, SlyA, SoxR, SoxS, SutR, TdcA, TdcR, TrpR, TyrR, UlaR, UvrY, YeiL, YiaJ, YjjQ, ppGpp
Summary: TF Summary ...[more]

REGULATION EXERTED BY IHF,PspF Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
IHF activator PspF activator    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
IHF activator pspGp pspG 4262771 4262783 -38.5 ttttgctgttAAATCAATAGATTatttttggca [ICA] [1]
PspF activator pspGp pspG 4262721 4262737 -87.0 tcaccaaaaaGTAGTCAAATTCACCACgccctgcgca [BPP]
[CV(CHIP-SV/GEA/ROMA)]
[CV(GEA/ROMA)]
[GEA]
[ICA]
[1]
PspF activator pspAp pspA , pspB , pspC , pspD , pspE 1367911 1367927 -119.0 gtattctgccATGATGAAATTCGCCACttgttagtgt [BCE]
[BPP]
[CV(CHIP-SV/GEA/ROMA)]
[CV(GEA/ROMA)]
[GEA]
[2]
[3]
[4]
PspF activator pspAp pspA , pspB , pspC , pspD , pspE 1367931 1367947 -99.0 tcgccacttgTTAGTGTAATTCGCTAActcatcctgg [BCE]
[BPP]
[CV(CHIP-SV/GEA/ROMA)]
[CV(GEA/ROMA)]
[GEA]
[2]
[3]
[4]
IHF activator pspAp pspA , pspB , pspC , pspD , pspE 1367989 1368001 -42.5 atcagatcttTATAAATCAAAAAgataaaaaat [APIORCISFBSCS]
[BCE]
[BPP]
[CV(CHIP-SV/GEA/ROMA)]
[CV(GEA/ROMA)]
[GEA]
[3]
[5]

Evidence: [ICA] Inferred by computational analysis
[BPP] Binding of purified proteins
[CV(CHIP-SV/GEA/ROMA)] cross validation(CHIP-SV/GEA/ROMA)
[CV(GEA/ROMA)] cross validation(GEA/ROMA)
[GEA] Gene expression analysis
[BCE] Binding of cellular extracts
[APIORCISFBSCS] A person inferred or reviewed a computer inference of sequence function based on similarity to a consensus sequence.
Reference(s): [1] Lloyd LJ., et al., 2004
[2] Jovanovic G., et al., 1997
[3] Jovanovic G., et al., 1997
[4] Jovanovic G., et al., 1999
[5] Weiner L., et al., 1995



Reference(s)    

 [1] Lloyd LJ., Jones SE., Jovanovic G., Gyaneshwar P., Rolfe MD., Thompson A., Hinton JC., Buck M., 2004, Identification of a new member of the phage shock protein response in Escherichia coli, the phage shock protein G (PspG)., J Biol Chem 279(53):55707-14

 [2] Jovanovic G., Dworkin J., Model P., 1997, Autogenous control of PspF, a constitutively active enhancer-binding protein of Escherichia coli., J Bacteriol 179(16):5232-7

 [3] Jovanovic G., Model P., 1997, PspF and IHF bind co-operatively in the psp promoter-regulatory region of Escherichia coli., Mol Microbiol 25(3):473-81

 [4] Jovanovic G., Rakonjac J., Model P., 1999, In vivo and in vitro activities of the Escherichia coli sigma54 transcription activator, PspF, and its DNA-binding mutant, PspFDeltaHTH., J Mol Biol 285(2):469-83

 [5] Weiner L., Brissette JL., Ramani N., Model P., 1995, Analysis of the proteins and cis-acting elements regulating the stress-induced phage shock protein operon., Nucleic Acids Res 23(11):2030-6


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