RegulonDB RegulonDB 10.8: Regulon Form
   
   


CRP,TorR regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
CRP Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class Using internal synthesized signals
Synonym(s): Cap, Csm, DNA-binding transcriptional dual regulator CRP, GurB
Gene name(s): crp
Functional conformation(s): CRP , CRP-cAMP
Coregulator(s): AcrR, AdiY, AgaR, AraC, ArcA, ArgP, ArgR, AscG, BasR, BtsR, CRP, CRP-Sxy, CaiF, ChbR, ComR, CpxR, Cra, CreB, CsgD, CspA, CsqR, CusR, CytR, DcuR, DeoR, DgoR, DksA-ppGpp, DnaA, DpiA, DsdC, EbgR, EnvY, EvgA, ExuR, FNR, FadR, FeaR, FhlA, Fis, FlhDC, FliZ, FucR, Fur, GadE, GadE-RcsB, GadW, GadX, GalR, GalS, GatR, GcvA, GlaR, GlcC, GlpR, GlrR, GntR, GutM, H-NS, HU, HdfR, HipB, HprR, HyfR, HypT, IHF, IclR, IdnR, LacI, LeuO, LexA, LrhA, Lrp, LsrR, MalI, MalT, MarA, MarR, MatA, McbR, MelR, MetJ, MhpR, Mlc, MlrA, ModE, MprA, MqsA, MurR, Nac, NadR, NagC, NanR, NarL, NarP, NrdR, NsrR, NtrC, OmpR, OxyR, PaaX, PdhR, PhoB, PhoP, PrpR, PurR, PuuR, QseB, RbsR, RcdA, RcsAB, RcsB, RcsB-BglJ, RhaR, RhaS, Rob, RstA, SdiA, SlyA, SoxR, SoxS, SrlR, StpA, TdcA, TdcR, TorR, TreR, UhpA, UidR, UlaR, UvrY, UxuR, XylR, YdeO, YiaJ, YjjQ, ZraR, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
TorR Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class External-Two-component systems
Synonym(s): DNA-binding transcriptional dual regulator TorR, TorR response regulator
Gene name(s): torR
Functional conformation(s): TorR-TorI , TorR-Pasp , TorR
Coregulator(s): AdiY, ArcA, CRP, FNR, Fis, FliZ, GadE, GadE-RcsB, GadW, GadX, H-NS, Lrp, MarA, NarL, PhoP, RcsB, TorR, ppGpp
Summary: TF Summary ...[more]

REGULATION EXERTED BY CRP,TorR Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
CRP activator TorR activator    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
TorR-Pasp activator tnaCp tnaC , tnaA , tnaB 3888351 3888360 -55.5 gattgtgattCGATTCACATttaaacaatt [BPP]
[GEA]
[1]
TorR-Pasp activator tnaCp tnaC , tnaA , tnaB 3888304 3888313 -102.5 cgtaatttatAATCTTTAAAaaaagcattt [BPP]
[GEA]
[1]
CRP-cAMP activator tnaCp tnaC , tnaA , tnaB 3888341 3888362 -59.5 ctccccgaacGATTGTGATTCGATTCACATTTaaacaatttc [AIBSCS]
[APIORCISFBSCS]
[BCE]
[CV(GEA/ROMA)]
[GEA]
[2]
[3]
[4]

Evidence: [BPP] Binding of purified proteins
[GEA] Gene expression analysis
[AIBSCS] Automated inference based on similarity to consensus sequences
[APIORCISFBSCS] A person inferred or reviewed a computer inference of sequence function based on similarity to a consensus sequence.
[BCE] Binding of cellular extracts
[CV(GEA/ROMA)] cross validation(GEA/ROMA)
Reference(s): [1] Bordi C., et al., 2003
[2] Deeley MC., et al., 1982
[3] Stewart V., et al., 1985
[4] Zheng D., et al., 2004



Reference(s)    

 [1] Bordi C., Theraulaz L., Mejean V., Jourlin-Castelli C., 2003, Anticipating an alkaline stress through the Tor phosphorelay system in Escherichia coli., Mol Microbiol 48(1):211-23

 [2] Deeley MC., Yanofsky C., 1982, Transcription initiation at the tryptophanase promoter of Escherichia coli K-12., J Bacteriol 151(2):942-51

 [3] Stewart V., Yanofsky C., 1985, Evidence for transcription antitermination control of tryptophanase operon expression in Escherichia coli K-12., J Bacteriol 164(2):731-40

 [4] Zheng D., Constantinidou C., Hobman JL., Minchin SD., 2004, Identification of the CRP regulon using in vitro and in vivo transcriptional profiling., Nucleic Acids Res 32(19):5874-93


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