RegulonDB RegulonDB 10.8: Regulon Form
   
   


NarL,TorR regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
NarL Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class External-Two-component systems
Synonym(s): DNA-binding transcriptional dual regulator NarL, FrdR, NarR, nitrate/nitrite response regulator NarL
Gene name(s): narL
Functional conformation(s): NarL , NarL-Phosphorylated
Coregulator(s): AppY, ArcA, CRP, Cra, DcuR, DpiA, EvgA, FNR, FhlA, Fis, FlhDC, Fur, H-NS, IHF, IscR, Lrp, ModE, NagC, NarL, NarP, NikR, NorR, NsrR, OxyR, PhoP, RcsB, RstA, SoxS, TorR, UvrY, YdeO
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
TorR Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class External-Two-component systems
Synonym(s): DNA-binding transcriptional dual regulator TorR, TorR response regulator
Gene name(s): torR
Functional conformation(s): TorR-TorI , TorR-Pasp , TorR
Coregulator(s): AdiY, ArcA, CRP, FNR, Fis, FliZ, GadE, GadE-RcsB, GadW, GadX, H-NS, Lrp, MarA, NarL, PhoP, RcsB, TorR, ppGpp
Summary: TF Summary ...[more]

REGULATION EXERTED BY NarL,TorR Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
NarL repressor TorR activator    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
TorR-Pasp activator torCp torC , torA , torD 1057973 1057982 -78.5 tttactcattCTGTTCATATctgttcatat [APIORCISFBSCS]
[BCE]
[BPP]
[CV(CHIP-SV/GEA/GS)]
[CV(CHIP-SV/GEA/ROMA)]
[CV(CHIP-SV/SM)]
[CV(GEA/GS)]
[CV(GEA/ROMA)]
[CV(GEA/ROMA/SM)]
[CV(GEA/SM/GS)]
[GEA]
[GS]
[SM]
[1]
[2]
[3]
TorR-Pasp activator torCp torC , torA , torD 1057983 1057992 -68.5 ctgttcatatCTGTTCATATtctgccgtaa [APIORCISFBSCS]
[BCE]
[BPP]
[CV(CHIP-SV/GEA/GS)]
[CV(CHIP-SV/GEA/ROMA)]
[CV(GEA/GS)]
[CV(GEA/ROMA)]
[GEA]
[GS]
[1]
[2]
[3]
TorR-Pasp activator torCp torC , torA , torD 1058002 1058011 -49.5 ttctgccgtaAGCCGTTCATcctgaccagt [APIORCISFBSCS]
[BCE]
[3]
TorR-Pasp activator torCp torC , torA , torD 1058026 1058035 -25.5 accagtgccgCTGTTCATATttgctcatta [APIORCISFBSCS]
[BCE]
[3]
NarL-Phosphorylated repressor torCp torC , torA , torD         [IMP] [4]

Evidence: [APIORCISFBSCS] A person inferred or reviewed a computer inference of sequence function based on similarity to a consensus sequence.
[BCE] Binding of cellular extracts
[BPP] Binding of purified proteins
[CV(CHIP-SV/GEA/GS)] cross validation(CHIP-SV/GEA/GS)
[CV(CHIP-SV/GEA/ROMA)] cross validation(CHIP-SV/GEA/ROMA)
[CV(CHIP-SV/SM)] cross validation(CHIP-SV/SM)
[CV(GEA/GS)] cross validation(GEA/GS)
[CV(GEA/ROMA)] cross validation(GEA/ROMA)
[CV(GEA/ROMA/SM)] cross validation(GEA/ROMA/SM)
[CV(GEA/SM/GS)] cross validation(GEA/SM/GS)
[GEA] Gene expression analysis
[GS] genomic SELEX
[SM] Site mutation
[IMP] Inferred from mutant phenotype
Reference(s): [1] Ansaldi M., et al., 2000
[2] Shimada T., et al., 2018
[3] Simon G., et al., 1995
[4] Iuchi S., et al., 1987



Reference(s)    

 [1] Ansaldi M., Simon G., Lepelletier M., Mejean V., 2000, The TorR high-affinity binding site plays a key role in both torR autoregulation and torCAD operon expression in Escherichia coli., J Bacteriol 182(4):961-6

 [2] Shimada T., Ogasawara H., Ishihama A., 2018, Single-target regulators form a minor group of transcription factors in Escherichia coli K-12., Nucleic Acids Res 46(8):3921-3936

 [3] Simon G., Jourlin C., Ansaldi M., Pascal MC., Chippaux M., Mejean V., 1995, Binding of the TorR regulator to cis-acting direct repeats activates tor operon expression., Mol Microbiol 17(5):971-80

 [4] Iuchi S., Lin EC., 1987, The narL gene product activates the nitrate reductase operon and represses the fumarate reductase and trimethylamine N-oxide reductase operons in Escherichia coli., Proc Natl Acad Sci U S A 84(11):3901-5


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