RegulonDB RegulonDB 10.8: Regulon Form
   
   


ArgP regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
ArgP      Tractordb tool
Connectivity class Local Regulator
Sensing Class Using internal synthesized signals
Synonym(s): DNA-binding transcriptional dual regulator ArgP, IciA
Gene name(s): argP
Functional conformation(s): ArgP-lysine , ArgP-arginine , ArgP
Coregulator(s): ArgP, CRP, DnaA, FNR, Fis, Fur, H-NS, Lrp, LysR, Nac, NrdR, PhoB, ppGpp
Summary: TF Summary ...[more]

REGULATION EXERTED BY ArgP Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
ArgP activator    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
ArgP activator dapBp1 dapB 28252 28271 -81.5 gactcatgccTTTCACTGATATCCCTCCCTgtttatcatt [APIORCISFBSCS]
[BCE]
[BPP]
[CV(CHIP-SV/GEA/ROMA)]
[CV(CHIP-SV/SM)]
[CV(GEA/ROMA)]
[CV(GEA/ROMA/SM)]
[GEA]
[IC]
[SM]
[1]
[2]
[3]
ArgP activator dapDp dapD         [BPP]
[GEA]
[2]
ArgP activator lysCp1 lysC         [BPP]
[GEA]
[2]
ArgP activator dapBp1 dapB 28272 28291 -61.5 atccctccctGTTTATCATTAATTTCTAATtatcagcgtt [BPP]
[CV(CHIP-SV/SM)]
[GEA]
[SM]
[3]

Evidence: [APIORCISFBSCS] A person inferred or reviewed a computer inference of sequence function based on similarity to a consensus sequence.
[BCE] Binding of cellular extracts
[BPP] Binding of purified proteins
[CV(CHIP-SV/GEA/ROMA)] cross validation(CHIP-SV/GEA/ROMA)
[CV(CHIP-SV/SM)] cross validation(CHIP-SV/SM)
[CV(GEA/ROMA)] cross validation(GEA/ROMA)
[CV(GEA/ROMA/SM)] cross validation(GEA/ROMA/SM)
[GEA] Gene expression analysis
[IC] Inferred by curator
[SM] Site mutation
Reference(s): [1] Bouvier J., et al., 2008
[2] Marbaniang CN., et al., 2011
[3] Nguyen Le Minh P., et al., 2018



Reference(s)    

 [1] Bouvier J., Stragier P., Morales V., Remy E., Gutierrez C., 2008, Lysine represses transcription of the Escherichia coli dapB gene by preventing its activation by the ArgP activator., J Bacteriol 190(15):5224-9

 [2] Marbaniang CN., Gowrishankar J., 2011, Role of ArgP (IciA) in Lysine-Mediated Repression in Escherichia coli., J Bacteriol 193(21):5985-96

 [3] Nguyen Le Minh P., Velazquez Ruiz C., Vandermeeren S., Abwoyo P., Bervoets I., Charlier D., 2018, Differential protein-DNA contacts for activation and repression by ArgP, a LysR-type (LTTR) transcriptional regulator in Escherichia coli., Microbiol Res 206:141-158


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