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AlaS regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
AlaS      Tractordb tool
Connectivity class Local Regulator
Synonym(s): Act, LovB, ala-act, alaninemdash;tRNA ligase/DNA-binding transcriptional repressor
Gene name(s): alaS
Functional conformation(s): AlaS , AlaS-L-alanine
Coregulator(s): AlaS
Summary: TF Summary ...[more]

REGULATION EXERTED BY AlaS Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
AlaS repressor    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
AlaS-L-alanine repressor alaSp alaS 2822080 2822114 -6.5 ttacttcccaGTCAAGAAAACTTATCTTATTCCCACTTTTCAGTTaccagcccgg [BPP]
[CV(CHIP-SV/SM)]
[GEA]
[SM]
[1]
[2]

Evidence: [BPP] Binding of purified proteins
[CV(CHIP-SV/SM)] cross validation(CHIP-SV/SM)
[GEA] Gene expression analysis
[SM] Site mutation
Reference(s): [1] Banerjee B., et al., 2019
[2] Putney SD., et al., 1981



Reference(s)    

 [1] Banerjee B., Ganguli S., Banerjee R., 2019, Biophysical characterization of interaction between E. coli alanyl-tRNA synethase with its promoter DNA., Protein Pept Lett

 [2] Putney SD., Schimmel P., 1981, An aminoacyl tRNA synthetase binds to a specific DNA sequence and regulates its gene transcription., Nature 291(5817):632-5


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