RegulonDB RegulonDB 10.8: Regulon Form
   
   


NagC regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
NagC Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class External sensing using transported metabolites
Synonym(s): DNA-binding transcriptional dual regulator NagC, NagR, transcriptional repressor of nag (N-acetylglucosamine) operon
Gene name(s): nagC
Functional conformation(s): NagC , NagC-N-acetyl-D-glucosamine 6-phosphate
Coregulator(s): AraC, BasR, CRP, ChbR, Cra, DksA, DksA-ppGpp, EvgA, FNR, Fur, GadX, GalR, GalS, H-NS, IHF, LexA, Mlc, NagC, NanR, NarL, NarP, PhoP, RcsB, UvrY, ppGpp
Summary: TF Summary ...[more]

REGULATION EXERTED BY NagC Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
NagC repressor    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
NagC repressor glmUp2 glmS , glmU 3915258 3915280 58.0 ttatcctctgTCCATTTCACGATGAAAAAAATGtagttttttc [APIORCISFBSCS]
[BPP]
[CV(CHIP-SV/SM)]
[SM]
[1]
[2]
NagC repressor glmUp2 glmS , glmU 3915411 3915433 -96.0 ctgttttcctGTTTATTCATTGATCGAAATAAGagcaaaaaca [APIORCISFBSCS]
[BPP]
[CV(CHIP-SV/SM)]
[SM]
[1]
[2]
NagC repressor creAp creA , creB , creC , creD 4635467 4635489 2.0 taatcaatatGTTATTTACCGTGACGAACTAATtgctcgtgta [AIBSCS] [3]
NagC repressor ptsHp3 ptsH , ptsI , crr 2533502 2533524 7.0 aaccagactaATTATTTTGATGCGCGAAATTAAtcgttacagg [AIBSCS] [3]
NagC activator    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
NagC activator glmUp1 glmS , glmU 3915258 3915280 -46.0 ttatcctctgTCCATTTCACGATGAAAAAAATGtagttttttc [APIORCISFBSCS]
[BPP]
[CV(CHIP-SV/SM)]
[SM]
[1]
[2]
NagC activator glmUp1 glmS , glmU 3915411 3915433 -199.0 ctgttttcctGTTTATTCATTGATCGAAATAAGagcaaaaaca [APIORCISFBSCS]
[BPP]
[CV(CHIP-SV/SM)]
[SM]
[1]
[2]

Evidence: [APIORCISFBSCS] A person inferred or reviewed a computer inference of sequence function based on similarity to a consensus sequence.
[BPP] Binding of purified proteins
[CV(CHIP-SV/SM)] cross validation(CHIP-SV/SM)
[SM] Site mutation
[AIBSCS] Automated inference based on similarity to consensus sequences
Reference(s): [1] Plumbridge J. 2001
[2] Plumbridge J. 1995
[3] Oberto J. 2010



Reference(s)    

 [1] Plumbridge J., 2001, DNA binding sites for the Mlc and NagC proteins: regulation of nagE, encoding the N-acetylglucosamine-specific transporter in Escherichia coli., Nucleic Acids Res 29(2):506-14

 [2] Plumbridge J., 1995, Co-ordinated regulation of amino sugar biosynthesis and degradation: the NagC repressor acts as both an activator and a repressor for the transcription of the glmUS operon and requires two separated NagC binding sites., EMBO J 14(16):3958-65

 [3] Oberto J., 2010, FITBAR: a web tool for the robust prediction of prokaryotic regulons., BMC Bioinformatics 11:554


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