RegulonDB RegulonDB 10.8: Regulon Form
   
   


Fis,MazE,MazE-MazF regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
Fis Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class TFs for DNA-bending
Synonym(s): DNA-binding transcriptional dual regulator Fis, Nbp, site-specific DNA inversion stimulation factor
Gene name(s): fis
Functional conformation(s): Fis
Coregulator(s): AcrR, AdiY, AppY, ArcA, ArgP, BasR, CRP, CpxR, Cra, CreB, CspA, CusR, CytR, DeoR, DksA, DksA-ppGpp, DnaA, FNR, FadR, Fis, FlhDC, FliZ, Fur, GadE, GadE-RcsB, GadW, GadX, GlcC, GlpR, H-NS, HprR, IHF, IscR, LeuO, Lrp, MalT, MarA, MarR, MazE, MazE-MazF, Mlc, MntR, ModE, NanR, NarL, NarP, NrdR, NsrR, NtrC, OmpR, OxyR, PdhR, PepA, PurR, RcsB, RcsB-BglJ, Rob, RstA, RutR, SlyA, SoxS, StpA, TorR, XylR, YdeO, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
MazE      Tractordb tool
Connectivity class Local Regulator
Synonym(s): ChpAI, ChpR, antitoxin of the MazF-MazE toxin-antitoxin system MazE
Gene name(s): mazE
Functional conformation(s): MazE
Coregulator(s): Fis, MazE, MazE-MazF, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
MazE-MazF      Tractordb tool
Connectivity class Local Regulator
Synonym(s): MazE-MazF "addiction module", MazE-MazF antitoxin/toxin complex / DNA-binding transcriptional repressor, MazFE
Gene name(s): mazE, mazF
Functional conformation(s): MazE-MazF
Coregulator(s): Fis, MazE, MazE-MazF, ppGpp
Summary: TF Summary ...[more]

REGULATION EXERTED BY Fis,MazE,MazE-MazF Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
Fis activator MazE repressor MazE-MazF repressor    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
Fis activator mazEp2 mazG , mazF , mazE 2911401 2911415 -53.5 gggagttaggCCGAAATTTGCTCGTatctacaatg [BPP]
[CV(CHIP-SV/SM)]
[GEA]
[SM]
[1]
MazE repressor mazEp2 mazG , mazF , mazE 2911363 2911388 -20.0 ctacaatgtaGATTGATATATACTGTATCTACATATgatagcggtt [BCE]
[CV(CHIP-SV/GEA/ROMA)]
[CV(CHIP-SV/SM)]
[CV(GEA/ROMA)]
[CV(GEA/ROMA/SM)]
[GEA]
[SM]
[1]
[2]
MazE repressor mazEp2 mazG , mazF , mazE 2911376 2911403 -34.0 gaaatttgctCGTATCTACAATGTAGATTGATATATACtgtatctaca [BCE]
[CV(CHIP-SV/GEA/ROMA)]
[CV(CHIP-SV/SM)]
[CV(GEA/ROMA)]
[CV(GEA/ROMA/SM)]
[GEA]
[SM]
[1]
MazE-MazF repressor mazEp2 mazG , mazF , mazE 2911362 2911389 -20.0 tctacaatgtAGATTGATATATACTGTATCTACATATGatagcggttt [BCE]
[CV(CHIP-SV/GEA/ROMA)]
[CV(CHIP-SV/SM)]
[CV(GEA/ROMA)]
[CV(GEA/ROMA/SM)]
[GEA]
[SM]
[1]
[2]
MazE-MazF repressor mazEp2 mazG , mazF , mazE 2911376 2911403 -34.0 gaaatttgctCGTATCTACAATGTAGATTGATATATACtgtatctaca [BCE]
[CV(CHIP-SV/GEA/ROMA)]
[CV(CHIP-SV/SM)]
[CV(GEA/ROMA)]
[CV(GEA/ROMA/SM)]
[GEA]
[SM]
[1]

Evidence: [BPP] Binding of purified proteins
[CV(CHIP-SV/SM)] cross validation(CHIP-SV/SM)
[GEA] Gene expression analysis
[SM] Site mutation
[BCE] Binding of cellular extracts
[CV(CHIP-SV/GEA/ROMA)] cross validation(CHIP-SV/GEA/ROMA)
[CV(GEA/ROMA)] cross validation(GEA/ROMA)
[CV(GEA/ROMA/SM)] cross validation(GEA/ROMA/SM)
Reference(s): [1] Marianovsky I., et al., 2001
[2] Masuda Y., et al., 1993



Reference(s)    

 [1] Marianovsky I., Aizenman E., Engelberg-Kulka H., Glaser G., 2001, The regulation of the Escherichia coli mazEF promoter involves an unusual alternating palindrome., J Biol Chem 276(8):5975-84

 [2] Masuda Y., Miyakawa K., Nishimura Y., Ohtsubo E., 1993, chpA and chpB, Escherichia coli chromosomal homologs of the pem locus responsible for stable maintenance of plasmid R100., J Bacteriol 175(21):6850-6


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