RegulonDB RegulonDB 10.8: Regulon Form
   
   


CRP,CspA,Fis regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
Fis Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class TFs for DNA-bending
Synonym(s): DNA-binding transcriptional dual regulator Fis, Nbp, site-specific DNA inversion stimulation factor
Gene name(s): fis
Functional conformation(s): Fis
Coregulator(s): AcrR, AdiY, AppY, ArcA, ArgP, BasR, CRP, CpxR, Cra, CreB, CspA, CusR, CytR, DeoR, DksA, DksA-ppGpp, DnaA, FNR, FadR, Fis, FlhDC, FliZ, Fur, GadE, GadE-RcsB, GadW, GadX, GlcC, GlpR, H-NS, HprR, IHF, IscR, LeuO, Lrp, MalT, MarA, MarR, MazE, MazE-MazF, Mlc, MntR, ModE, NanR, NarL, NarP, NrdR, NsrR, NtrC, OmpR, OxyR, PdhR, PepA, PurR, RcsB, RcsB-BglJ, Rob, RstA, RutR, SlyA, SoxS, StpA, TorR, XylR, YdeO, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
CRP Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class Using internal synthesized signals
Synonym(s): Cap, Csm, DNA-binding transcriptional dual regulator CRP, GurB
Gene name(s): crp
Functional conformation(s): CRP , CRP-cAMP
Coregulator(s): AcrR, AdiY, AgaR, AraC, ArcA, ArgP, ArgR, AscG, BasR, BtsR, CRP, CRP-Sxy, CaiF, ChbR, ComR, CpxR, Cra, CreB, CsgD, CspA, CsqR, CusR, CytR, DcuR, DeoR, DgoR, DksA-ppGpp, DnaA, DpiA, DsdC, EbgR, EnvY, EvgA, ExuR, FNR, FadR, FeaR, FhlA, Fis, FlhDC, FliZ, FucR, Fur, GadE, GadE-RcsB, GadW, GadX, GalR, GalS, GatR, GcvA, GlaR, GlcC, GlpR, GlrR, GntR, GutM, H-NS, HU, HdfR, HipB, HprR, HyfR, HypT, IHF, IclR, IdnR, LacI, LeuO, LexA, LrhA, Lrp, LsrR, MalI, MalT, MarA, MarR, MatA, McbR, MelR, MetJ, MhpR, Mlc, MlrA, ModE, MprA, MqsA, MurR, Nac, NadR, NagC, NanR, NarL, NarP, NrdR, NsrR, NtrC, OmpR, OxyR, PaaX, PdhR, PhoB, PhoP, PrpR, PurR, PuuR, QseB, RbsR, RcdA, RcsAB, RcsB, RcsB-BglJ, RhaR, RhaS, Rob, RstA, SdiA, SlyA, SoxR, SoxS, SrlR, StpA, TdcA, TdcR, TorR, TreR, UhpA, UidR, UlaR, UvrY, UxuR, XylR, YdeO, YiaJ, YjjQ, ZraR, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
CspA      Tractordb tool
Connectivity class Local Regulator
Synonym(s): CS7.4, DNA-binding transcriptional activator CspA, F10.6, cold shock protein CspA, major cold shock protein 7.4
Gene name(s): cspA
Functional conformation(s): CspA
Coregulator(s): CRP, CspA, Fis, GadX, H-NS
Summary: TF Summary ...[more]

REGULATION EXERTED BY CRP,CspA,Fis Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
CRP activator CspA activator Fis repressor    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
CspA activator gyrAp gyrA 2339514 2339520 -60.0 tatatcaggcATTGGATgtgaataaag [APIORCISFBSCS] [1]
CspA activator gyrAp gyrA 2339542 2339548 -88.0 ctactccgtaATTGGCAagacaaacga [APIORCISFBSCS] [1]
CspA activator gyrAp gyrA 2339562 2339568 -108.0 ttcggcattcATTGGCActtctactcc [APIORCISFBSCS] [1]
Fis repressor gyrAp gyrA 2339492 2339506 -42.5 gatgtgaataAAGCGTATAGGTTTAcctcaaactg [APIORCISFBSCS]
[BPP]
[CV(CHIP-SV/GEA/ROMA)]
[CV(GEA/ROMA)]
[GEA]
[2]
[3]
CRP-cAMP activator gyrAp gyrA         [GEA] [4]

Evidence: [APIORCISFBSCS] A person inferred or reviewed a computer inference of sequence function based on similarity to a consensus sequence.
[BPP] Binding of purified proteins
[CV(CHIP-SV/GEA/ROMA)] cross validation(CHIP-SV/GEA/ROMA)
[CV(GEA/ROMA)] cross validation(GEA/ROMA)
[GEA] Gene expression analysis
Reference(s): [1] Jones PG., et al., 1992
[2] Cameron AD., et al., 2011
[3] Schneider R., et al., 1999
[4] Gomez-Gomez JM., et al., 1996



Reference(s)    

 [1] Jones PG., Krah R., Tafuri SR., Wolffe AP., 1992, DNA gyrase, CS7.4, and the cold shock response in Escherichia coli., J Bacteriol 174(18):5798-802

 [2] Cameron AD., Stoebel DM., Dorman CJ., 2011, DNA supercoiling is differentially regulated by environmental factors and FIS in Escherichia coli and Salmonella enterica., Mol Microbiol 80(1):85-101

 [3] Schneider R., Travers A., Kutateladze T., Muskhelishvili G., 1999, A DNA architectural protein couples cellular physiology and DNA topology in Escherichia coli., Mol Microbiol 34(5):953-64

 [4] Gomez-Gomez JM., Baquero F., Blazquez J., 1996, Cyclic AMP receptor protein positively controls gyrA transcription and alters DNA topology after nutritional upshift in Escherichia coli., J Bacteriol 178(11):3331-4


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