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CpxR regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
CpxR Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class External-Two-component systems
Synonym(s): CpxR response regulator, DNA-binding transcriptional dual regulator CpxR, YiiA
Gene name(s): cpxR
Functional conformation(s): CpxR-Phosphorylated , CpxR
Coregulator(s): AcrR, BaeR, BasR, BolA, BtsR, CRP, CpxR, Cra, CsgD, CysB, EnvY, Fis, FliZ, Fur, GadE, H-NS, IHF, Lrp, MarA, MarR, MlrA, MqsA, NsrR, OmpR, PdhR, PhoB, RcdA, RcsAB, RcsB, Rob, RstA, SoxS, TyrR, YjjQ, ppGpp
Summary: TF Summary ...[more]

REGULATION EXERTED BY CpxR Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
CpxR activator    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
CpxR-Phosphorylated activator yqjAp1 yqjA , mzrA 3247494 3247508 -47.0 agtataaagtGTCAGCCTGTGTAAATcctctcgcca   [1]
CpxR-Phosphorylated activator yccAp yccA 1031489 1031503 -53.0 agatcaaatgCGTAAAGATGGGTAAAacttctgggt   [2]
[1]
CpxR-Phosphorylated activator ftnBp2 ftnB 1986731 1986745 -61.0 tcaatgaaatGTAAAAATATATAAACttgatgattt   [1]
CpxR-Phosphorylated activator yebEp yebE 1929769 1929783 -44.0 tttgcgcatcTTTTGTCTCGATATACattttctgac   [2]
[1]
CpxR-Phosphorylated activator ldtCp ldtC 1170463 1170479 -53.5 catctgcaacATTTACAAATTCTTTGCacttccctgc   [1]
CpxR-Phosphorylated activator ppiAp1 ppiA 3492375 3492389 -47.0 atttcagataCGTAAAATTAGGTAAAgggatggcct   [3]
[4]
[1]
CpxR-Phosphorylated activator ppiDp2 ppiD 461647 461661 -165.0 ccgcagaccgGTAAAGAGATCACCATcgctgctgct   [5]
CpxR-Phosphorylated activator ppiDp2 ppiD 461695 461709 -117.0 ttccgtgcagGTAAAGCACTGAAAGAcgcggtaaac   [5]
CpxR-Phosphorylated activator ppiDp2 ppiD 461715 461731 -96.5 gaaagacgcgGTAAACTAAGCGTTGTCcccagtgggg   [5]
CpxR-Phosphorylated activator bacAp bacA 3204460 3204474 -292.0 gtgggataacCGTAAAGCGGCGAAAAgtgatgatgt   [6]
CpxR-Phosphorylated activator cpxPp cpxP , cpxQ 4105726 4105740 -52.0 aatccatgacTTTACGTTGTTTTACAccccctgacg   [7]
[2]
[1]
CpxR-Phosphorylated activator cpxPp cpxP , cpxQ 4105771 4105790 -5.0 agcctgaatcGTAAACTCTCTATCGTTGAAtcgcgacaga   [7]
[2]
[1]
CpxR-Phosphorylated activator srkAp srkA , dsbA 4042335 4042349 -49.0 taattaaagaGTAAAAGCTTGTAAGCggcgccacca   [8]
[4]
[1]
CpxR-Phosphorylated activator cpxRp cpxA , cpxR 4105746 4105760 -67.0 cgattcaggcTGCAAACATGCGTCAGggggtgtaaa   [7]
CpxR-Phosphorylated activator cpxRp cpxA , cpxR 4105726 4105740 -47.0 cgtcagggggTGTAAAACAACGTAAAgtcatggatt   [7]
CpxR-Phosphorylated activator dsbCp dsbC 3039184 3039198 -357.5 gtgccgttagGTGAAGAGGCGGTTTActggctggaa   [9]
CpxR-Phosphorylated activator yidQp yidQ 3867393 3867409 -143.5 tagcagaacgGTAAAGCGGGGATAAATcaaagttacg   [9]
CpxR-Phosphorylated activator yidQp yidQ 3867360 3867377 -176.0 tttctaagtgGTTAAACAAACGGTCAAAtccaatagca   [9]
CpxR-Phosphorylated activator yidQp yidQ 3867282 3867299 -254.0 tagcaatgcgGTAATGGTTTTCGTCTACcagttcaacg   [9]
CpxR-Phosphorylated activator dsbCp dsbC 3039219 3039233 -391.5 acgggtcattGGTAAAGGCAACAAAgagcgtctgg   [9]
CpxR-Phosphorylated activator cpxPp cpxP , cpxQ 4105746 4105760 -32.0 tttacaccccCTGACGCATGTTTGCAgcctgaatcg [APIORCISFBSCS] [7]
[2]
CpxR-Phosphorylated activator yqaEp kbp , yqaE 2797126 2797141 -48.0 gcctcagcagCGTAAATGAGAGTAAAagcgtaagct   [10]
[2]
[11]
CpxR-Phosphorylated activator sltp7 slt 4630641 4630656 -52.0 aaaagtgtccGTAACGTGGCGTAAACggcaatgact   [10]
[2]
CpxR-Phosphorylated activator ldtDp ldtD 980732 980747 -192.0 gatttgcgccGCAACTCCCTGAAACGcttccaggaa   [10]
CpxR-Phosphorylated activator sbmAp sbmA , yaiW

Evidence: [APIORCISFBSCS] A person inferred or reviewed a computer inference of sequence function based on similarity to a consensus sequence.
Reference(s): [1] Yamamoto K., et al., 2006
[2] Raivio TL., et al., 2013
[3] Oshima T., et al., 2002
[4] Pogliano J., et al., 1997
[5] Dartigalongue C., et al., 1998
[6] De Wulf P., et al., 2002
[7] De Wulf P., et al., 1999
[8] Danese PN., et al., 1997
[9] Dartigalongue C., et al., 2001
[10] Bernal-Cabas M., et al., 2015
[11] Vogt SL., et al., 2014



Reference(s)    

 [1] Yamamoto K., Ishihama A., 2006, Characterization of copper-inducible promoters regulated by CpxA/CpxR in Escherichia coli., Biosci Biotechnol Biochem 70(7):1688-95

 [2] Raivio TL., Leblanc SK., Price NL., 2013, The Escherichia coli Cpx envelope stress response regulates genes of diverse function that impact antibiotic resistance and membrane integrity., J Bacteriol 195(12):2755-67

 [3] Oshima T., Aiba H., Masuda Y., Kanaya S., Sugiura M., Wanner BL., Mori H., Mizuno T., 2002, Transcriptome analysis of all two-component regulatory system mutants of Escherichia coli K-12., Mol Microbiol 46(1):281-91

 [4] Pogliano J., Lynch AS., Belin D., Lin EC., Beckwith J., 1997, Regulation of Escherichia coli cell envelope proteins involved in protein folding and degradation by the Cpx two-component system., Genes Dev 11(9):1169-82

 [5] Dartigalongue C., Raina S., 1998, A new heat-shock gene, ppiD, encodes a peptidyl-prolyl isomerase required for folding of outer membrane proteins in Escherichia coli., EMBO J 17(14):3968-80

 [6] De Wulf P., McGuire AM., Liu X., Lin EC., 2002, Genome-wide profiling of promoter recognition by the two-component response regulator CpxR-P in Escherichia coli., J Biol Chem 277(29):26652-61

 [7] De Wulf P., Kwon O., Lin EC., 1999, The CpxRA signal transduction system of Escherichia coli: growth-related autoactivation and control of unanticipated target operons., J Bacteriol 181(21):6772-8

 [8] Danese PN., Silhavy TJ., 1997, The sigma(E) and the Cpx signal transduction systems control the synthesis of periplasmic protein-folding enzymes in Escherichia coli., Genes Dev 11(9):1183-93

 [9] Dartigalongue C., Missiakas D., Raina S., 2001, Characterization of the Escherichia coli sigma E regulon., J Biol Chem 276(24):20866-75

 [10] Bernal-Cabas M., Ayala JA., Raivio TL., 2015, The Cpx Envelope Stress Response Modifies Peptidoglycan Cross-Linking via the l,d-Transpeptidase LdtD and the Novel Protein YgaU., J Bacteriol 197(3):603-14

 [11] Vogt SL., Evans AD., Guest RL., Raivio TL., 2014, The Cpx envelope stress response regulates and is regulated by small noncoding RNAs., J Bacteriol 196(24):4229-38

 [12] Zahrl D., Wagner M., Bischof K., Koraimann G., 2006, Expression and assembly of a functional type IV secretion system elicit extracytoplasmic and cytoplasmic stress responses in Escherichia coli., J Bacteriol 188(18):6611-21

 [13] Ogasawara H., Teramoto J., Hirao K., Yamamoto K., Ishihama A., Utsumi R., 2004, Negative regulation of DNA repair gene (ung) expression by the CpxR/CpxA two-component system in Escherichia coli K-12 and induction of mutations by increased expression of CpxR., J Bacteriol 186(24):8317-25


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