RegulonDB RegulonDB 10.9: Regulon Form
   
   


CsgD regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
CsgD Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Synonym(s): DNA-binding transcriptional dual regulator CsgD
Gene name(s): csgD
Functional conformation(s): CsgD
Coregulator(s): BasR, BolA, BtsR, CRP, CpxR, Cra, CsgD, DksA-ppGpp, FlhDC, FliZ, H-NS, IHF, MatA, MlrA, MqsA, NsrR, OmpR, RcdA, RcsAB, RstA, SutR, ppGpp
Summary: TF Summary ...[more]

REGULATION EXERTED BY CsgD Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
CsgD repressor    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
CsgD repressor pepDp3 pepD 255731 255741 2.0 atactgttttGCGGGTGATCGAcaaggagact   [1]
CsgD repressor ubiTp2 yhbS , ubiT 3301280 3301294 15.5 atgattgttgAAACAGGGAGTAAAActcgtgttgg   [2]
CsgD repressor ubiTp2 yhbS , ubiT 3301307 3301321 -12.5 gttatttttcTGATATGGCAAAATAggatgattgt   [2]
CsgD repressor fliEp fliE 2013069 2013083 18.5 ttttttgttgCTATTTAGCGCCTTTgtcttattga [APIORCISFBSCS]
[BPP]
[GEA]
[2]
CsgD repressor fliEp fliE 2013054 2013068 33.5 tagcgcctttGTCTTATTGACTTACtggtaggctt [APIORCISFBSCS]
[BPP]
[GEA]
[2]
CsgD repressor flgMp flgN , flgM 1130158 1130172 1.5 cttgccgataAATAAGCAACACATGataaaagcgc   [3]
CsgD repressor flgMp flgN , flgM 1130142 1130156 17.5 caacacatgaTAAAAGCGCCCTCAAtgaggaataa   [3]
CsgD activator    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
CsgD activator adrAp dgcC 403615 403629 -65.5 ctgatagtgcTAACGGGTGAGCTACgaaaatggct   [1]
[2]
CsgD activator adrAp dgcC 403635 403645 -47.0 gctacgaaaaTGGCTCACCCGAaatatcatac   [1]
CsgD activator yccTp yccT 1027873 1027887 -42.5 aaccatgcagCTAATACGAATGAATgagagcaaaa   [2]
CsgD activator nlpAp nlpA 3840102 3840116 -91.5 cgtggtcagtAAGAAGTGCCAGACTttatattcca   [2]
CsgD activator nlpAp nlpA 3840087 3840101 -76.5 gtgccagactTTATATTCCACTTTTattccttttt   [2]
CsgD activator wrbAp yccJ , wrbA 1067866 1067880 -114.5 tatgattaaaAAAACGCGATGAGATaaaaatgtgt   [2]
CsgD activator wrbAp yccJ , wrbA 1067888 1067902 -136.5 ataattatccATAAGCCGCTCTTATgattaaaaaa   [2]
CsgD activator wrbAp yccJ , wrbA 1067918 1067932 -166.5 gcttcttagcGAGAATAGATATCATctccaataat   [2]

Evidence: [APIORCISFBSCS] A person inferred or reviewed a computer inference of sequence function based on similarity to a consensus sequence.
[BPP] Binding of purified proteins
[GEA] Gene expression analysis
Reference(s): [1] Brombacher E., et al., 2003
[2] Ogasawara H., et al., 2011
[3] Dudin O., et al., 2014



Reference(s)    

 [1] Brombacher E., Dorel C., Zehnder AJ., Landini P., 2003, The curli biosynthesis regulator CsgD co-ordinates the expression of both positive and negative determinants for biofilm formation in Escherichia coli., Microbiology 149(Pt 10):2847-57

 [2] Ogasawara H., Yamamoto K., Ishihama A., 2011, Role of the biofilm master regulator CsgD in cross-regulation between biofilm formation and flagellar synthesis., J Bacteriol 193(10):2587-97

 [3] Dudin O., Geiselmann J., Ogasawara H., Ishihama A., Lacour S., 2014, Repression of flagellar genes in exponential phase by CsgD and CpxR, two crucial modulators of Escherichia coli biofilm formation., J Bacteriol 196(3):707-15


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