RegulonDB RegulonDB 10.9: Regulon Form
   
   


IscR regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
IscR Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Synonym(s): DNA-binding transcriptional dual regulator IscR, YfhP
Gene name(s): iscR
Functional conformation(s): IscR-2Fe-2S , IscR
Coregulator(s): AppY, ArcA, Fis, Fur, IHF, IscR, NarL, NarP, NrdR, NsrR, OxyR, YdeO
Summary: TF Summary ...[more]

REGULATION EXERTED BY IscR Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
IscR repressor    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
IscR repressor napFp3 napC , napB , napH , napG , napA , napD , napF 2303677 2303701 7.0 taaatatattTATAACCATTTGAAATGTGAGCAAAAgcccgttttt   [1]
IscR repressor erpAp erpA 176521 176545 -28.0 gccagcgagaATACTTGAACGAAATACCAGGGTATTagataatggc   [1]
IscR repressor nfuAp1 nfuA 3545587 3545611 4.0 tgggcgtattATAACCAACTAAAATAGTCAACTATTaggccattac   [1]
IscR repressor rnlAp2 rnlA , rnlB 2765852 2765876 -29.5 taaatttagcAAATCAATACACTTCAGGGGGGTATTattgtagagt   [2]
IscR-2Fe-2S repressor iscRp iscA , iscU , iscS , iscR 2662240 2662264 -53.0 ctgaaggttaAATACCCGACTAAATCAGTCAAGTAAatagttgacc   [3]
[1]
[4]
IscR-2Fe-2S repressor iscRp iscA , iscU , iscS , iscR 2662215 2662239 -28.0 cagtcaagtaAATAGTTGACCAATTTACTCGGGAATgtcagacttg   [3]
[1]
[5]
[4]
IscR activator    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
IscR activator ydiUp ydiU 1791286 1791310 -44.0 ttggttcagcGATAACCCTTCTGTTTGCTGGTGTTTaagacgagag   [1]

Reference(s): [1] Giel JL., et al., 2006
[2] Otsuka Y., et al., 2010
[3] Giel JL., et al., 2013
[4] Yeo WS., et al., 2006
[5] Schwartz CJ., et al., 2001



Reference(s)    

 [1] Giel JL., Rodionov D., Liu M., Blattner FR., Kiley PJ., 2006, IscR-dependent gene expression links iron-sulphur cluster assembly to the control of O-regulated genes in Escherichia coli., Mol Microbiol 60(4):1058-75

 [2] Otsuka Y., Miki K., Koga M., Katayama N., Morimoto W., Takahashi Y., Yonesaki T., 2010, IscR regulates RNase LS activity by repressing rnlA transcription., Genetics 185(3):823-30

 [3] Giel JL., Nesbit AD., Mettert EL., Fleischhacker AS., Wanta BT., Kiley PJ., 2013, Regulation of iron-sulphur cluster homeostasis through transcriptional control of the Isc pathway by [2Fe-2S]-IscR in Escherichia coli., Mol Microbiol 87(3):478-92

 [4] Yeo WS., Lee JH., Lee KC., Roe JH., 2006, IscR acts as an activator in response to oxidative stress for the suf operon encoding Fe-S assembly proteins., Mol Microbiol 61(1):206-18

 [5] Schwartz CJ., Giel JL., Patschkowski T., Luther C., Ruzicka FJ., Beinert H., Kiley PJ., 2001, IscR, an Fe-S cluster-containing transcription factor, represses expression of Escherichia coli genes encoding Fe-S cluster assembly proteins., Proc Natl Acad Sci U S A 98(26):14895-900


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