RegulonDB RegulonDB 10.9: Regulon Form
   
   


PhoP regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
PhoP      Tractordb tool
Connectivity class Local Regulator
Sensing Class External-Two-component systems
Synonym(s): DNA-binding transcriptional dual regulator PhoP, PhoP response regulator
Gene name(s): phoP
Functional conformation(s): PhoP-Phosphorylated , PhoP
Coregulator(s): AcrR, ArcA, ArgR, BasR, CRP, CysB, EnvR, EvgA, FNR, FadR, FliZ, GadE, GadW, GadX, H-NS, HypT, Lrp, MalT, MarA, MetJ, MprA, NagC, NarL, NarP, NtrC, OmpR, PdhR, PhoP, PurR, RbsR, RcsB, Rob, RutR, SdiA, SlyA, SoxR, SoxS, TorR, UvrY, YdeO, ppGpp
Summary: TF Summary ...[more]

REGULATION EXERTED BY PhoP Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
PhoP activator    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
PhoP-Phosphorylated activator phoPp2 phoQ , phoP 1190508 1190524 -8.0 ccctccccgcTGGTTTATTTAATGTTTAcccccataac   [1]
[2]
[3]
PhoP-Phosphorylated activator nagAp nagA 703198 703214 -31.0 aaaaattcatCTGTTTATGGGCGGTGTAggtaacgacg   [2]
PhoP-Phosphorylated activator ybjGp ybjG 883532 883548 -32.0 tagctacgctTTCTTTAAGTTTTATTTAacctatgccc   [1]
PhoP-Phosphorylated activator borDp borD 578946 578962 -33.0 tttcaactcaTTGTTTAGGGTTTGTTTAattttctaca   [2]
PhoP-Phosphorylated activator rstAp rstA , rstB 1682086 1682102 -44.0 gatgaaaactTGTTTAGAAACGATTGATagtaagtaaa   [2]
[3]
PhoP-Phosphorylated activator slyBp1 slyB 1719736 1719752 -33.0 atgaatgtttTGTTTATAATTGGTTGATcctactttca   [2]
PhoP-Phosphorylated activator mgtAp1 mgtL , mgtA 4467321 4467337 -34.0 ggtaaagtctGGTTTATCGTTGGTTTAGttgtcagcag   [4]
[2]
[5]
[6]
PhoP-Phosphorylated activator mgrBp mgrB 1908817 1908833 -33.0 gaatatcgacATAGTTAGGCGCTGTTTAactaacgcat   [1]
[4]
[2]
PhoP-Phosphorylated activator tolCp2 tolC , ygiB , ygiC 3177958 3177975 -46.0 atttcagcgaCGTTTGACTGCCGTTTGAgcagtcatgt   [7]
PhoP-Phosphorylated activator mgrRp mgrR 1622950 1622966 -44.0 gtgattaaccGAGTTTAAGCTCCGTTTAacattcattg   [8]
PhoP-Phosphorylated activator ompTp ompT 585706 585722 -49.0 taaacaaaatATAAACAGTGGAGCAATAtgtaattgac   [9]
PhoP-Phosphorylated activator mgtSp mgtS 1622545 1622561 -35.0 ataaagatttAATTCAGCCTTCGTTTAGgttacctctg   [8]
PhoP-Phosphorylated activator iraMp2 iraM 1212150 1212166 -35.0 aaatctcattTTGTTTAACATCCATTGAgattccttgc [APIORCISFBSCS]
[BPP]
[GEA]
[10]
[11]
PhoP-Phosphorylated activator glgBp glgP , glgA , glgC , glgX , glgB 3573683 3573699 -34.0 agatgtttcaTGATTTACCGGGAGTTAAatagagcatt   [12]
PhoP-Phosphorylated activator glgAp glgP , glgA

Evidence: [APIORCISFBSCS] A person inferred or reviewed a computer inference of sequence function based on similarity to a consensus sequence.
[BPP] Binding of purified proteins
[GEA] Gene expression analysis
Reference(s): [1] Eguchi Y., et al., 2004
[2] Minagawa S., et al., 2003
[3] Monsieurs P., et al., 2005
[4] Kato A., et al., 1999
[5] Oshima T., et al., 2002
[6] Yamamoto K., et al., 2002
[7] Eguchi Y., et al., 2003
[8] Moon K., et al., 2009
[9] Zwir I., et al., 2005
[10] Bougdour A., et al., 2008
[11] Eguchi Y., et al., 2011
[12] Montero M., et al., 2011



Reference(s)    

 [1] Eguchi Y., Okada T., Minagawa S., Oshima T., Mori H., Yamamoto K., Ishihama A., Utsumi R., 2004, Signal transduction cascade between EvgA/EvgS and PhoP/PhoQ two-component systems of Escherichia coli., J Bacteriol 186(10):3006-14

 [2] Minagawa S., Ogasawara H., Kato A., Yamamoto K., Eguchi Y., Oshima T., Mori H., Ishihama A., Utsumi R., 2003, Identification and molecular characterization of the Mg2+ stimulon of Escherichia coli., J Bacteriol 185(13):3696-702

 [3] Monsieurs P., De Keersmaecker S., Navarre WW., Bader MW., De Smet F., McClelland M., Fang FC., De Moor B., Vanderleyden J., Marchal K., 2005, Comparison of the PhoPQ regulon in Escherichia coli and Salmonella typhimurium., J Mol Evol 60(4):462-74

 [4] Kato A., Tanabe H., Utsumi R., 1999, Molecular characterization of the PhoP-PhoQ two-component system in Escherichia coli K-12: identification of extracellular Mg2+-responsive promoters., J Bacteriol 181(17):5516-20

 [5] Oshima T., Aiba H., Masuda Y., Kanaya S., Sugiura M., Wanner BL., Mori H., Mizuno T., 2002, Transcriptome analysis of all two-component regulatory system mutants of Escherichia coli K-12., Mol Microbiol 46(1):281-91

 [6] Yamamoto K., Ogasawara H., Fujita N., Utsumi R., Ishihama A., 2002, Novel mode of transcription regulation of divergently overlapping promoters by PhoP, the regulator of two-component system sensing external magnesium availability., Mol Microbiol 45(2):423-38

 [7] Eguchi Y., Oshima T., Mori H., Aono R., Yamamoto K., Ishihama A., Utsumi R., 2003, Transcriptional regulation of drug efflux genes by EvgAS, a two-component system in Escherichia coli., Microbiology 149(Pt 10):2819-28

 [8] Moon K., Gottesman S., 2009, A PhoQ/P-regulated small RNA regulates sensitivity of Escherichia coli to antimicrobial peptides., Mol Microbiol 74(6):1314-30

 [9] Zwir I., Shin D., Kato A., Nishino K., Latifi T., Solomon F., Hare JM., Huang H., Groisman EA., 2005, Dissecting the PhoP regulatory network of Escherichia coli and Salmonella enterica., Proc Natl Acad Sci U S A 102(8):2862-7

 [10] Bougdour A., Cunning C., Baptiste PJ., Elliott T., Gottesman S., 2008, Multiple pathways for regulation of sigmaS (RpoS) stability in Escherichia coli via the action of multiple anti-adaptors., Mol Microbiol 68(2):298-313

 [11] Eguchi Y., Ishii E., Hata K., Utsumi R., 2011, Regulation of acid resistance by connectors of two-component signal transduction systems in Escherichia coli., J Bacteriol 193(5):1222-8

 [12] Montero M., Almagro G., Eydallin G., Viale AM., Munoz FJ., Bahaji A., Li J., Rahimpour M., Baroja-Fernandez E., Pozueta-Romero J., 2011, Escherichia coli glycogen genes are organized in a single glgBXCAP transcriptional unit possessing an alternative suboperonic promoter within glgC that directs glgAP expression., Biochem J 433(1):107-17

 [13] Yeom J., Gao X., Groisman EA., 2018, Reduction in adaptor amounts establishes degradation hierarchy among protease substrates., Proc Natl Acad Sci U S A 115(19):E4483-E4492


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