RegulonDB RegulonDB 10.9: Regulon Form
   
   


CRP,IHF regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
CRP Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class Using internal synthesized signals
Synonym(s): Cap, Csm, DNA-binding transcriptional dual regulator CRP, GurB
Gene name(s): crp
Functional conformation(s): CRP-cAMP , CRP
Coregulator(s): AcrR, AdiY, AgaR, AraC, ArcA, ArgP, ArgR, AscG, BasR, BolA, BtsR, CRP, CRP-Sxy, CaiF, ChbR, ComR, CpxR, Cra, CreB, CsgD, CspA, CsqR, CusR, CytR, DcuR, DeoR, DgoR, DksA-ppGpp, DnaA, DpiA, DsdC, EbgR, EnvY, EvgA, ExuR, FNR, FadR, FeaR, FhlA, Fis, FlhDC, FliZ, FucR, Fur, GadE, GadE-RcsB, GadW, GadX, GalR, GalS, GatR, GcvA, GlaR, GlcC, GlpR, GlrR, GntR, GutM, H-NS, HU, HdfR, HipB, HprR, HyfR, HypT, IHF, IclR, IdnR, LacI, LeuO, LexA, LrhA, Lrp, LsrR, MalI, MalT, MarA, MarR, MatA, McbR, MelR, MetJ, MhpR, Mlc, MlrA, ModE, MprA, MqsA, MurR, Nac, NadR, NagC, NanR, NarL, NarP, NrdR, NsrR, NtrC, OmpR, OxyR, PaaX, PdhR, PhoB, PhoP, PrpR, PurR, PuuR, QseB, RbsR, RcdA, RcsAB, RcsB, RcsB-BglJ, RhaR, RhaS, Rob, RstA, SdiA, SlyA, SoxR, SoxS, SrlR, StpA, TdcA, TdcR, TorR, TreR, UhpA, UidR, UlaR, UvrY, UxuR, XylR, YdeO, YiaJ, YjjQ, ZraR, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
IHF Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Synonym(s): DNA-binding transcriptional dual regulator IHF
Gene name(s): ihfB, ihfA
Functional conformation(s): IHF
Coregulator(s): AcrR, AdiY, ArcA, ArgR, AtoC, BasR, BolA, BtsR, CRP, Cbl, CpxR, Cra, CsgD, CysB, DksA, DksA-ppGpp, EnvY, FNR, FadR, FhlA, Fis, FlhDC, FliZ, Fur, GadE, GlcC, GlpR, GlrR, H-NS, HU, HdfR, HipAB, HipB, IHF, IclR, IscR, LrhA, Lrp, MarA, MatA, MlrA, MntR, ModE, MprA, MqsA, Nac, NagC, NanR, NarL, NarP, NorR, NsrR, NtrC, OmpR, OxyR, PaaX, PdhR, PepA, PhoB, PspF, PurR, QseB, RcdA, RcsAB, Rob, RstA, RtcR, RutR, SlyA, SoxR, SoxS, SutR, TdcA, TdcR, TrpR, TyrR, UlaR, UvrY, YeiL, YiaJ, YjjQ, ppGpp
Summary: TF Summary ...[more]

REGULATION EXERTED BY CRP,IHF Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
CRP repressor IHF repressor    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
IHF repressor ompRp1 envZ , ompR 3536694 3536706 8.0 tacttaagctGCTGTTTAATATGCtttgtaacaa   [1]
IHF repressor ompRp1 envZ , ompR 3536738 3536750 -37.0 gatcatatcaACAGAATCAATAATgtttcgccga   [1]
IHF repressor ompRp1 envZ , ompR 3536803 3536815 -102.0 caggggcgttTTCATCTCGTTGATtccctttgtc   [1]
CRP-cAMP repressor ompRp1 envZ , ompR 3536749 3536770 -53.0 gcgcacattgGGTATAACGTGATCATATCAACAgaatcaataa   [2]
CRP activator IHF repressor    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
CRP-cAMP activator hptp hpt 141284 141305 -65.5 aggttttaacATGTGTGATCGTCATCACAATTCgagctttatt   [3]
IHF repressor hptp hpt 141330 141342 -24.0 agattccgcgAATGAATAGTTTTActggtatact   [3]
CRP repressor IHF activator    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
IHF activator gcdp1 gcd 141330 141342 -73.0 agtataccagTAAAACTATTCATTcgcggaatct   [3]
CRP-cAMP repressor gcdp1 gcd 141284 141305 -31.5 aataaagctcGAATTGTGATGACGATCACACATgttaaaacct   [3]
[4]

Reference(s): [1] Tsui P., et al., 1991
[2] Huang L., et al., 1992
[3] Izu H., et al., 2002
[4] Yamada M., et al., 1993



Reference(s)    

 [1] Tsui P., Huang L., Freundlich M., 1991, Integration host factor binds specifically to multiple sites in the ompB promoter of Escherichia coli and inhibits transcription., J Bacteriol 173(18):5800-7

 [2] Huang L., Tsui P., Freundlich M., 1992, Positive and negative control of ompB transcription in Escherichia coli by cyclic AMP and the cyclic AMP receptor protein., J Bacteriol 174(3):664-70

 [3] Izu H., Ito S., Elias MD., Yamada M., 2002, Differential control by IHF and cAMP of two oppositely oriented genes, hpt and gcd, in Escherichia coli: significance of their partially overlapping regulatory elements., Mol Genet Genomics 266(5):865-72

 [4] Yamada M., Asaoka S., Saier MH., Yamada Y., 1993, Characterization of the gcd gene from Escherichia coli K-12 W3110 and regulation of its expression., J Bacteriol 175(2):568-71


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