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HypT,MetJ regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
MetJ Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class Using internal synthesized signals
Synonym(s): B3938, MetJ, MetJ-SAM
Gene name(s): metJ
Functional conformation(s): MetJ-S-adenosyl-L-methionine , MetJ-adenine , MetJ-MTA , MetJ
Coregulator(s): CRP, HypT, MetJ, MetR, OxyR, PhoP
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
HypT      Tractordb tool
Connectivity class Local Regulator
Synonym(s): DNA-binding transcriptional dual regulator HypT, QseD, YjiE
Gene name(s): hypT
Functional conformation(s): HypT-Met-oxidized
Coregulator(s): ArcA, AscG, CRP, FNR, Fur, H-NS, HypT, MetJ, PdhR, PhoP
Summary: TF Summary ...[more]

REGULATION EXERTED BY HypT,MetJ Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
HypT activator MetJ repressor    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
MetJ-S-adenosyl-L-methionine repressor metNp metQ , metI , metN 222732 222747 -25.5 aaacctgattGATTTAGACGTCTGGATgccttaacat   [1]
[2]
[3]
MetJ-S-adenosyl-L-methionine repressor metNp metQ , metI , metN 222724 222739 -17.5 ttgatttagaCGTCTGGATGCCTTAACatccatttca   [1]
[2]
HypT-Met-oxidized activator metNp metQ , metI , metN

Reference(s): [1] Gal J., et al., 2002
[2] Marincs F., et al., 2006
[3] Merlin C., et al., 2002



Reference(s)    

 [1] Gal J., Szvetnik A., Schnell R., Kalman M., 2002, The metD D-methionine transporter locus of Escherichia coli is an ABC transporter gene cluster., J Bacteriol 184(17):4930-2

 [2] Marincs F., Manfield IW., Stead JA., McDowall KJ., Stockley PG., 2006, Transcript analysis reveals an extended regulon and the importance of protein-protein co-operativity for the Escherichia coli methionine repressor., Biochem J 396(2):227-34

 [3] Merlin C., Gardiner G., Durand S., Masters M., 2002, The Escherichia coli metD locus encodes an ABC transporter which includes Abc (MetN), YaeE (MetI), and YaeC (MetQ)., J Bacteriol 184(19):5513-7

 [4] Drazic A., Miura H., Peschek J., Le Y., Bach NC., Kriehuber T., Winter J., 2013, Methionine oxidation activates a transcription factor in response to oxidative stress., Proc Natl Acad Sci U S A 110(23):9493-8

 [5] Gebendorfer KM., Drazic A., Le Y., Gundlach J., Bepperling A., Kastenmuller A., Ganzinger KA., Braun N., Franzmann TM., Winter J., 2012, Identification of a Hypochlorite-specific Transcription Factor from Escherichia coli., J Biol Chem 287(9):6892-903


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