RegulonDB RegulonDB 10.9: Regulon Form
   
   


CRP,Fis,IHF regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
Fis      Tractordb tool
Connectivity class Global Regulator
Sensing Class TFs for DNA-bending
Synonym(s): DNA-binding transcriptional dual regulator Fis, Nbp, site-specific DNA inversion stimulation factor
Gene name(s): fis
Functional conformation(s): Fis
Coregulator(s): AcrR, AdiY, AppY, ArcA, ArgP, BasR, CRP, CpxR, Cra, CreB, CspA, CusR, CytR, DeoR, DksA, DksA-ppGpp, DnaA, FNR, FadR, Fis, FlhDC, FliZ, Fur, GadE, GadE-RcsB, GadW, GadX, GlcC, GlpR, H-NS, HprR, IHF, IscR, LeuO, Lrp, MalT, MarA, MarR, MazE, MazE-MazF, Mlc, MntR, ModE, NanR, NarL, NarP, NrdR, NsrR, NtrC, OmpR, OxyR, PdhR, PepA, PurR, RcsB, RcsB-BglJ, Rob, RstA, RutR, SlyA, SoxS, StpA, TorR, XylR, YdeO, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
CRP      Tractordb tool
Connectivity class Global Regulator
Sensing Class Using internal synthesized signals
Synonym(s): Cap, Csm, DNA-binding transcriptional dual regulator CRP, GurB
Gene name(s): crp
Functional conformation(s): CRP-cAMP , CRP
Coregulator(s): AcrR, AdiY, AgaR, AraC, ArcA, ArgP, ArgR, AscG, BasR, BolA, BtsR, CRP, CRP-Sxy, CaiF, ChbR, ComR, CpxR, Cra, CreB, CsgD, CspA, CsqR, CusR, CytR, DcuR, DeoR, DgoR, DksA-ppGpp, DnaA, DpiA, DsdC, EbgR, EnvY, EvgA, ExuR, FNR, FadR, FeaR, FhlA, Fis, FlhDC, FliZ, FucR, Fur, GadE, GadE-RcsB, GadW, GadX, GalR, GalS, GatR, GcvA, GlaR, GlcC, GlpR, GlrR, GntR, GutM, H-NS, HU, HdfR, HipB, HprR, HyfR, HypT, IHF, IclR, IdnR, LacI, LeuO, LexA, LrhA, Lrp, LsrR, MalI, MalT, MarA, MarR, MatA, McbR, MelR, MetJ, MhpR, Mlc, MlrA, ModE, MprA, MqsA, MurR, Nac, NadR, NagC, NanR, NarL, NarP, NrdR, NsrR, NtrC, OmpR, OxyR, PaaX, PdhR, PhoB, PhoP, PrpR, PurR, PuuR, QseB, RbsR, RcdA, RcsAB, RcsB, RcsB-BglJ, RhaR, RhaS, Rob, RstA, SdiA, SlyA, SoxR, SoxS, SrlR, StpA, TdcA, TdcR, TorR, TreR, UhpA, UidR, UlaR, UvrY, UxuR, XylR, YdeO, YiaJ, YjjQ, ZraR, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
IHF      Tractordb tool
Connectivity class Global Regulator
Synonym(s): DNA-binding transcriptional dual regulator IHF
Gene name(s): ihfB, ihfA
Functional conformation(s): IHF
Coregulator(s): AcrR, AdiY, ArcA, ArgR, AtoC, BasR, BolA, BtsR, CRP, Cbl, CpxR, Cra, CsgD, CysB, DksA, DksA-ppGpp, EnvY, FNR, FadR, FhlA, Fis, FlhDC, FliZ, Fur, GadE, GlcC, GlpR, GlrR, H-NS, HU, HdfR, HipAB, HipB, IHF, IclR, IscR, LrhA, Lrp, MarA, MatA, MlrA, MntR, ModE, MprA, MqsA, Nac, NagC, NanR, NarL, NarP, NorR, NsrR, NtrC, OmpR, OxyR, PaaX, PdhR, PepA, PhoB, PspF, PurR, QseB, RcdA, RcsAB, Rob, RstA, RtcR, RutR, SlyA, SoxR, SoxS, SutR, TdcA, TdcR, TrpR, TyrR, UlaR, UvrY, YeiL, YiaJ, YjjQ, ppGpp
Summary: TF Summary ...[more]

REGULATION EXERTED BY CRP,Fis,IHF Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
CRP activator Fis repressor IHF repressor    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
IHF repressor acsp2 actP , yjcH , acs 4287565 4287577 -180.0 gtcagtatctTCCTCTTTTTCAACagcatgcata   [1]
CRP-cAMP activator acsp2 actP , yjcH , acs 4287503 4287524 -122.5 attaatcaacTTTTGTTGCTGACCTTCAAAAATtaccctgccg   [2]
[3]
[4]
CRP-cAMP activator acsp2 actP , yjcH , acs 4287450 4287471 -69.5 caattctactTTTGCGTGATCTGTCGCCCAAATactaaacaaa   [2]
[3]
[4]
IHF repressor acsp2 actP , yjcH , acs 4287538 4287550 -153.0 atgcataactGCATGTTCCTCAAAgaattaatca   [1]
[4]
IHF repressor acsp2 actP , yjcH , acs 4287610 4287622 -225.0 tctttaatcaATTGTAAGTGCATGtaaaatacca   [5]
[6]
Fis repressor acsp2 actP , yjcH , acs 4287482 4287496 -98.0 aaaattacccTGCCGTTTATTTGCACaattctactt   [1]
Fis repressor acsp2 actP , yjcH , acs 4287443 4287457 -59.0 cgtgatctgtCGCCCAAATACTAAACaaaactgcca   [1]
Fis repressor acsp2 actP , yjcH , acs 4287649 4287663 -265.0 ctcgcccctaTGTGTAACAAATAACCacactgtgaa   [1]
[5]
[6]
Fis repressor acsp actP , yjcH , acs 4287443 4287457 -59.0 cgtgatctgtCGCCCAAATACTAAACaaaactgcca   [1]
Fis repressor acsp actP , yjcH , acs 4287649 4287663 -265.0 ctcgcccctaTGTGTAACAAATAACCacactgtgaa   [1]
[5]
[6]
IHF repressor acsp actP , yjcH , acs 4287565 4287577 -180.0 gtcagtatctTCCTCTTTTTCAACagcatgcata   [1]
CRP-cAMP activator acsp actP , yjcH , acs 4287450 4287471 -69.5 caattctactTTTGCGTGATCTGTCGCCCAAATactaaacaaa   [2]
[3]
[4]
IHF repressor acsp actP , yjcH , acs 4287610 4287622 -225.0 tctttaatcaATTGTAAGTGCATGtaaaatacca   [5]
[6]
CRP-cAMP activator acsp actP , yjcH , acs 4287503 4287524 -122.5 attaatcaacTTTTGTTGCTGACCTTCAAAAATtaccctgccg   [2]
[3]
[4]
IHF repressor acsp actP , yjcH , acs 4287538 4287550 -153.0 atgcataactGCATGTTCCTCAAAgaattaatca   [1]
[4]
Fis repressor acsp actP , yjcH , acs 4287482 4287496 -98.0 aaaattacccTGCCGTTTATTTGCACaattctactt   [1]

Reference(s): [1] Browning DF., et al., 2004
[2] Beatty CM., et al., 2003
[3] Kumari S., et al., 2000
[4] Sclavi B., et al., 2007
[5] Browning DF., et al., 2002
[6] Browning DF., et al., 2005



Reference(s)    

 [1] Browning DF., Beatty CM., Sanstad EA., Gunn KE., Busby SJ., Wolfe AJ., 2004, Modulation of CRP-dependent transcription at the Escherichia coli acsP2 promoter by nucleoprotein complexes: anti-activation by the nucleoid proteins FIS and IHF., Mol Microbiol 51(1):241-54

 [2] Beatty CM., Browning DF., Busby SJ., Wolfe AJ., 2003, Cyclic AMP receptor protein-dependent activation of the Escherichia coli acsP2 promoter by a synergistic class III mechanism., J Bacteriol 185(17):5148-57

 [3] Kumari S., Beatty CM., Browning DF., Busby SJ., Simel EJ., Hovel-Miner G., Wolfe AJ., 2000, Regulation of acetyl coenzyme A synthetase in Escherichia coli., J Bacteriol 182(15):4173-9

 [4] Sclavi B., Beatty CM., Thach DS., Fredericks CE., Buckle M., Wolfe AJ., 2007, The multiple roles of CRP at the complex acs promoter depend on activation region 2 and IHF., Mol Microbiol 65(2):425-40

 [5] Browning DF., Beatty CM., Wolfe AJ., Cole JA., Busby SJ., 2002, Independent regulation of the divergent Escherichia coli nrfA and acsP1 promoters by a nucleoprotein assembly at a shared regulatory region., Mol Microbiol 43(3):687-701

 [6] Browning DF., Grainger DC., Beatty CM., Wolfe AJ., Cole JA., Busby SJ., 2005, Integration of three signals at the Escherichia coli nrf promoter: a role for Fis protein in catabolite repression., Mol Microbiol 57(2):496-510


RegulonDB