RegulonDB RegulonDB 10.9: Regulon Form
   
   


CRP,Fis,H-NS,LeuO,RcsB-BglJ,StpA regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
Fis Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class TFs for DNA-bending
Synonym(s): DNA-binding transcriptional dual regulator Fis, Nbp, site-specific DNA inversion stimulation factor
Gene name(s): fis
Functional conformation(s): Fis
Coregulator(s): AcrR, AdiY, AppY, ArcA, ArgP, BasR, CRP, CpxR, Cra, CreB, CspA, CusR, CytR, DeoR, DksA, DksA-ppGpp, DnaA, FNR, FadR, Fis, FlhDC, FliZ, Fur, GadE, GadE-RcsB, GadW, GadX, GlcC, GlpR, H-NS, HprR, IHF, IscR, LeuO, Lrp, MalT, MarA, MarR, MazE, MazE-MazF, Mlc, MntR, ModE, NanR, NarL, NarP, NrdR, NsrR, NtrC, OmpR, OxyR, PdhR, PepA, PurR, RcsB, RcsB-BglJ, Rob, RstA, RutR, SlyA, SoxS, StpA, TorR, XylR, YdeO, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
CRP Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class Using internal synthesized signals
Synonym(s): Cap, Csm, DNA-binding transcriptional dual regulator CRP, GurB
Gene name(s): crp
Functional conformation(s): CRP-cAMP , CRP
Coregulator(s): AcrR, AdiY, AgaR, AraC, ArcA, ArgP, ArgR, AscG, BasR, BolA, BtsR, CRP, CRP-Sxy, CaiF, ChbR, ComR, CpxR, Cra, CreB, CsgD, CspA, CsqR, CusR, CytR, DcuR, DeoR, DgoR, DksA-ppGpp, DnaA, DpiA, DsdC, EbgR, EnvY, EvgA, ExuR, FNR, FadR, FeaR, FhlA, Fis, FlhDC, FliZ, FucR, Fur, GadE, GadE-RcsB, GadW, GadX, GalR, GalS, GatR, GcvA, GlaR, GlcC, GlpR, GlrR, GntR, GutM, H-NS, HU, HdfR, HipB, HprR, HyfR, HypT, IHF, IclR, IdnR, LacI, LeuO, LexA, LrhA, Lrp, LsrR, MalI, MalT, MarA, MarR, MatA, McbR, MelR, MetJ, MhpR, Mlc, MlrA, ModE, MprA, MqsA, MurR, Nac, NadR, NagC, NanR, NarL, NarP, NrdR, NsrR, NtrC, OmpR, OxyR, PaaX, PdhR, PhoB, PhoP, PrpR, PurR, PuuR, QseB, RbsR, RcdA, RcsAB, RcsB, RcsB-BglJ, RhaR, RhaS, Rob, RstA, SdiA, SlyA, SoxR, SoxS, SrlR, StpA, TdcA, TdcR, TorR, TreR, UhpA, UidR, UlaR, UvrY, UxuR, XylR, YdeO, YiaJ, YjjQ, ZraR, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
H-NS      Tractordb tool
Connectivity class Global Regulator
Synonym(s): BglY, Cur, DNA-binding protein HLP-II (HU, BH2, HD, NS), DNA-binding transcriptional dual regulator H-NS, Drc, DrdX, Drs, FimG, Hns, HnsA, Irk, MsyA, OsmZ, PilG, TopS, TopX, VirR
Gene name(s): hns
Functional conformation(s): H-NS
Coregulator(s): AcrR, AdiY, ArcA, ArgP, ArgR, BasR, BolA, BtsR, CRP, CadC, CaiF, CdaR, CpxR, Cra, CreB, CsgD, CspA, CysB, DksA, DksA-ppGpp, DnaA, DpiA, EvgA, FNR, Fis, FlhDC, FliZ, Fur, GadE, GadE-RcsB, GadW, GadX, GalR, GalS, GlaR, GutM, H-NS, HU, HdfR, HypT, IHF, LacI, LeuO, LrhA, Lrp, MalT, MarA, MatA, McbR, MlrA, MntR, MqsA, NagC, NanR, NarL, NarP, NhaR, NrdR, NsrR, OmpR, OxyR, PhoB, PhoP, QseB, RcdA, RcsAB, RcsB, RcsB-BglJ, Rob, RstA, RutR, SdiA, SlyA, SoxS, SrlR, StpA, SutR, TorR, UvrY, YdeO, YjjQ, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
LeuO Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class Using internal synthesized signals
Synonym(s): DNA-binding transcriptional dual regulator LeuO
Gene name(s): leuO
Functional conformation(s): LeuO
Coregulator(s): CRP, CadC, DksA-ppGpp, FNR, Fis, H-NS, LeuO, LrhA, MlrA, OmpR, RcsB-BglJ, SlyA, StpA, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
StpA      Tractordb tool
Connectivity class Local Regulator
Synonym(s): DNA-binding transcriptional repressor StpA with RNA chaperone activity, H-NS-like DNA-binding transcriptional repressor with RNA chaperone activity, HnsB
Gene name(s): stpA
Functional conformation(s): StpA
Coregulator(s): CRP, CreB, Fis, H-NS, LeuO, Lrp, MalT, RcsB-BglJ, SlyA, StpA
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
RcsB-BglJ      Tractordb tool
Connectivity class Local Regulator
Synonym(s): RcsB-BglJ DNA-binding transcriptional activator, RcsBgl
Gene name(s): bglJ, rcsB
Functional conformation(s): RcsB-BglJ
Coregulator(s): CRP, Fis, H-NS, LeuO, LexA, RcsB-BglJ, StpA
Summary: TF Summary ...[more]

REGULATION EXERTED BY CRP,Fis,H-NS,LeuO,RcsB-BglJ,StpA Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
CRP activator Fis repressor H-NS repressor LeuO activator RcsB-BglJ activator StpA repressor    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
CRP-cAMP activator bglGp bglB , bglF , bglG 3906748 3906769 -61.5 acaaagttaaTAACTGCGAGCATGGTCATATTTttatcaatag   [1]
[2]
H-NS repressor bglGp bglB , bglF , bglG 3906011 3906025 680.0 cagttaatgcGCGAAATGCTGCAATTaataaaattt   [3]
[4]
[5]
[6]
Fis repressor bglGp bglB , bglF , bglG 3906742 3906756 -52.0 ctgcgagcatGGTCATATTTTTATCAatagcgcatt   [7]
Fis repressor bglGp bglB , bglF , bglG 3906717 3906731 -27.0 aatagcgcatTGCTATTTTCTCTGCAcgcaattaaa   [7]
LeuO activator bglGp bglB , bglF , bglG 3906805 3906825 -118.0 caataacttaATTATTGGGATTTGTTATATATaactttataa   [5]
[6]
RcsB-BglJ activator bglGp bglB , bglF , bglG 3906783 3906802 -95.5 gttatatataACTTTATAAATTCCTAAAATTacacaaagtt   [8]
[9]
[6]
LeuO activator bglGp bglB , bglF , bglG 3906836 3906856 -149.0 gatagcgacaAATAATTCACCAGACAAATCCCaataacttaa   [5]
[6]
StpA repressor bglGp bglB , bglF , bglG

Reference(s): [1] Gulati A., et al., 2000
[2] Zheng D., et al., 2004
[3] Dole S., et al., 2004
[4] Schnetz K., et al., 1996
[5] Ueguchi C., et al., 1998
[6] Venkatesh GR., et al., 2010
[7] Caramel A., et al., 2000
[8] Giel M., et al., 1996
[9] Madhusudan S., et al., 2005



Reference(s)    

 [1] Gulati A., Mahadevan S., 2000, Mechanism of catabolite repression in the bgl operon of Escherichia coli: involvement of the anti-terminator BglG, CRP-cAMP and EIIAGlc in mediating glucose effect downstream of transcription initiation., Genes Cells 5(4):239-50

 [2] Zheng D., Constantinidou C., Hobman JL., Minchin SD., 2004, Identification of the CRP regulon using in vitro and in vivo transcriptional profiling., Nucleic Acids Res 32(19):5874-93

 [3] Dole S., Nagarajavel V., Schnetz K., 2004, The histone-like nucleoid structuring protein H-NS represses the Escherichia coli bgl operon downstream of the promoter., Mol Microbiol 52(2):589-600

 [4] Schnetz K., Wang JC., 1996, Silencing of the Escherichia coli bgl promoter: effects of template supercoiling and cell extracts on promoter activity in vitro., Nucleic Acids Res 24(12):2422-8

 [5] Ueguchi C., Ohta T., Seto C., Suzuki T., Mizuno T., 1998, The leuO gene product has a latent ability to relieve bgl silencing in Escherichia coli., J Bacteriol 180(1):190-3

 [6] Venkatesh GR., Kembou Koungni FC., Paukner A., Stratmann T., Blissenbach B., Schnetz K., 2010, BglJ-RcsB heterodimers relieve repression of the Escherichia coli bgl operon by H-NS., J Bacteriol 192(24):6456-64

 [7] Caramel A., Schnetz K., 2000, Antagonistic control of the Escherichia coli bgl promoter by FIS and CAP in vitro., Mol Microbiol 36(1):85-92

 [8] Giel M., Desnoyer M., Lopilato J., 1996, A mutation in a new gene, bglJ, activates the bgl operon in Escherichia coli K-12., Genetics 143(2):627-35

 [9] Madhusudan S., Paukner A., Klingen Y., Schnetz K., 2005, Independent regulation of H-NS-mediated silencing of the bgl operon at two levels: upstream by BglJ and LeuO and downstream by DnaKJ., Microbiology 151(Pt 10):3349-59

 [10] Gueune H., Durand MJ., Thouand G., DuBow MS., 2008, The ygaVP genes of Escherichia coli form a tributyltin-inducible operon., Appl Environ Microbiol 74(6):1954-8

 [11] Sun D., Mao X., Fei M., Chen Z., Zhu T., Qiu J., 2020, Histone-like Nucleoid-Structuring Protein (H-NS) Paralogue StpA Activates the Type I-E CRISPR-Cas System against Natural Transformation in Escherichia coli., Appl Environ Microbiol 86(14)


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