RegulonDB RegulonDB 10.9: Regulon Form
   
   


CRP,UvrY regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
CRP Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class Using internal synthesized signals
Synonym(s): Cap, Csm, DNA-binding transcriptional dual regulator CRP, GurB
Gene name(s): crp
Functional conformation(s): CRP-cAMP , CRP
Coregulator(s): AcrR, AdiY, AgaR, AraC, ArcA, ArgP, ArgR, AscG, BasR, BolA, BtsR, CRP, CRP-Sxy, CaiF, ChbR, ComR, CpxR, Cra, CreB, CsgD, CspA, CsqR, CusR, CytR, DcuR, DeoR, DgoR, DksA-ppGpp, DnaA, DpiA, DsdC, EbgR, EnvY, EvgA, ExuR, FNR, FadR, FeaR, FhlA, Fis, FlhDC, FliZ, FucR, Fur, GadE, GadE-RcsB, GadW, GadX, GalR, GalS, GatR, GcvA, GlaR, GlcC, GlpR, GlrR, GntR, GutM, H-NS, HU, HdfR, HipB, HprR, HyfR, HypT, IHF, IclR, IdnR, LacI, LeuO, LexA, LrhA, Lrp, LsrR, MalI, MalT, MarA, MarR, MatA, McbR, MelR, MetJ, MhpR, Mlc, MlrA, ModE, MprA, MqsA, MurR, Nac, NadR, NagC, NanR, NarL, NarP, NrdR, NsrR, NtrC, OmpR, OxyR, PaaX, PdhR, PhoB, PhoP, PrpR, PurR, PuuR, QseB, RbsR, RcdA, RcsAB, RcsB, RcsB-BglJ, RhaR, RhaS, Rob, RstA, SdiA, SlyA, SoxR, SoxS, SrlR, StpA, TdcA, TdcR, TorR, TreR, UhpA, UidR, UlaR, UvrY, UxuR, XylR, YdeO, YiaJ, YjjQ, ZraR, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
UvrY      Tractordb tool
Connectivity class Local Regulator
Sensing Class External-Two-component systems
Synonym(s): DNA-binding transcriptional activator UvrY, UvrY response regulator, YecB
Gene name(s): uvrY
Functional conformation(s): UvrY-phosphorylated , UvrY
Coregulator(s): CRP, EvgA, H-NS, IHF, NagC, NarL, NarP, PhoP, RcsB, UhpA, UvrY
Summary: TF Summary ...[more]

REGULATION EXERTED BY CRP,UvrY Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
CRP repressor UvrY activator    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
UvrY-phosphorylated activator csrCp csrC 4050868 4050886 -159.0 ccatacgcttTGTGAGACATTGCCGATAGtctttatgcg   [1]
CRP-cAMP repressor csrCp csrC 4050915 4050931 -113.5 gagaaaattcTGCGATGCATGTCAAATaagctatata   [2]
CRP-cAMP repressor csrCp csrC 4050868 4050884 -160.5 ccatacgcttTGTGAGACATTGCCGATagtctttatg   [2]
CRP-cAMP repressor csrCp csrC 4050837 4050853 -191.5 gatttttcggCGTGAGCGTTGTAAGTAaaagccatac   [2]

Reference(s): [1] Zere TR., et al., 2015
[2] Pannuri A., et al., 2016



Reference(s)    

 [1] Zere TR., Vakulskas CA., Leng Y., Pannuri A., Potts AH., Dias R., Tang D., Kolaczkowski B., Georgellis D., Ahmer BM., Romeo T., 2015, Genomic Targets and Features of BarA-UvrY (-SirA) Signal Transduction Systems., PLoS One 10(12):e0145035

 [2] Pannuri A., Vakulskas CA., Zere T., McGibbon LC., Edwards AN., Georgellis D., Babitzke P., Romeo T., 2016, Circuitry Linking the Catabolite Repression and Csr Global Regulatory Systems of Escherichia coli., J Bacteriol 198(21):3000-3015


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