RegulonDB RegulonDB 10.9: Regulon Form
   
   


ArgR regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
ArgR Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class Sensing external and internal signals
Synonym(s): DNA-binding transcriptional dual regulator ArgR, XerA
Gene name(s): argR
Functional conformation(s): ArgR , ArgR-L-arginine
Coregulator(s): AdiY, ArgR, CRP, DksA-ppGpp, FNR, Fur, GadE, H-NS, HdfR, IHF, Lrp, Nac, NtrC, PhoP, ppGpp
Summary: TF Summary ...[more]

REGULATION EXERTED BY ArgR Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
ArgR repressor    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
ArgR-L-arginine repressor argCp argC , argB , argH 4154873 4154890 -3.5 ggtcatgataGTATCAATATTCATGCAGTatttatgaat   [1]
ArgR-L-arginine repressor argCp argC , argB , argH 4154895 4154912 19.5 atgcagtattTATGAATAAAAATACACTAacgttgagcg [EME] [2]
[1]
ArgR-L-arginine repressor argEp1 argE 4154873 4154890 16.5 attcataaatACTGCATGAATATTGATACtatcatgacc   [2]
[1]
ArgR-L-arginine repressor argEp1 argE 4154895 4154912 -6.5 cgctcaacgtTAGTGTATTTTTATTCATAaatactgcat [EME] [2]
[1]
ArgR-L-arginine repressor argFp argF 290354 290371 -22.5 atggggttgcAAATGAATAATTACACATAtaaagtgaat   [2]
[1]
[3]
ArgR-L-arginine repressor argFp argF 290333 290350 -1.5 tacacatataAAGTGAATTTTAATTCAATaagtggcgtt [EME] [2]
[1]
[4]
ArgR-L-arginine repressor argRp1 argR 3384641 3384658 -27.5 gggctgactgTTTGCATAAAAATTCATCTgtatgcacaa   [2]
[1]
[3]
ArgR-L-arginine repressor argRp1 argR 3384661 3384678 -7.5 aattcatctgTATGCACAATAATGTTGTAtcaaccacca [EME] [2]
[1]
[3]
ArgR-L-arginine repressor carAp2 carA , carB 29602 29619 -8.5 acgtcatcatTGTGAATTAATATGCAAATaaagtgagtg   [2]
[1]
ArgR-L-arginine repressor carAp2 carA , carB 29623 29640 13.5 atgcaaataaAGTGAGTGAATATTCTCTGgagggtgttt [EME] [2]
[1]
ArgR-L-arginine repressor artJp artJ 900645 900663 -27.5 taatcatgttTATTGCATATAAATTCACTtgatggcatt   [2]
[5]
ArgR-L-arginine repressor artJp artJ 900666 900684 -48.5 ttttatttcaTTTAAATTATTTAATCATGtttattgcat [EME] [2]
[5]
ArgR-L-arginine repressor argAp argA 2949214 2949231 67.5 atacactaatTTCGAATAATCATGCAAAGaggtgtgccg [EME] [2]
[1]
ArgR-L-arginine repressor argAp argA 2949193 2949211 46.5 ctgcgaaaaaACAGAATAAAAATACACTAatttcgaata   [2]
[1]
ArgR-L-arginine repressor lysOp lysO 914921 914938 -34.5 atttccttttAATTGCAACTTTACTCGTCcttccgcttt   [6]
ArgR-L-arginine repressor lysOp lysO 914942 914959 -55.5 ctactgctccTTATGCATAACATTTCCTTttaattgcaa [EME] [2]
[6]
ArgR-L-arginine repressor artPp artM , artQ , artI , artP 903811 903829 -50.5 tgcgctttgcTTTTAACTTTTAAAGCAGAaatattgcat [EME] [2]
[5]
ArgR-L-arginine repressor artPp artM , artQ , artI , artP 903790 903808 -29.5 aaagcagaaaTATTGCATAATTATTCTGTcaaaggtact   [2]
[5]

Evidence: [EME] Expression microarray evidence
Reference(s): [1] Charlier D., et al., 1992
[2] Caldara M., et al., 2006
[3] Levitt M. 1992
[4] Tian G., et al., 1994
[5] Caldara M., et al., 2007
[6] Pathania A., et al., 2015



Reference(s)    

 [1] Charlier D., Roovers M., Van Vliet F., Boyen A., Cunin R., Nakamura Y., Glansdorff N., Pierard A., 1992, Arginine regulon of Escherichia coli K-12. A study of repressor-operator interactions and of in vitro binding affinities versus in vivo repression., J Mol Biol 226(2):367-86

 [2] Caldara M., Charlier D., Cunin R., 2006, The arginine regulon of Escherichia coli: whole-system transcriptome analysis discovers new genes and provides an integrated view of arginine regulation., Microbiology 152(Pt 11):3343-54

 [3] Levitt M., 1992, Accurate modeling of protein conformation by automatic segment matching., J Mol Biol 226(2):507-33

 [4] Tian G., Maas WK., 1994, Mutational analysis of the arginine repressor of Escherichia coli., Mol Microbiol 13(4):599-608

 [5] Caldara M., Minh PN., Bostoen S., Massant J., Charlier D., 2007, ArgR-dependent repression of arginine and histidine transport genes in Escherichia coli K-12., J Mol Biol 373(2):251-67

 [6] Pathania A., Sardesai AA., 2015, Distinct Paths for Basic Amino Acid Export in Escherichia coli: YbjE (LysO) Mediates Export of L-Lysine., J Bacteriol 197(12):2036-47


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