RegulonDB RegulonDB 10.9: Regulon Form
   
   


CRP,GalR,GalS,HU regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
CRP Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class Using internal synthesized signals
Synonym(s): Cap, Csm, DNA-binding transcriptional dual regulator CRP, GurB
Gene name(s): crp
Functional conformation(s): CRP-cAMP , CRP
Coregulator(s): AcrR, AdiY, AgaR, AraC, ArcA, ArgP, ArgR, AscG, BasR, BolA, BtsR, CRP, CRP-Sxy, CaiF, ChbR, ComR, CpxR, Cra, CreB, CsgD, CspA, CsqR, CusR, CytR, DcuR, DeoR, DgoR, DksA-ppGpp, DnaA, DpiA, DsdC, EbgR, EnvY, EvgA, ExuR, FNR, FadR, FeaR, FhlA, Fis, FlhDC, FliZ, FucR, Fur, GadE, GadE-RcsB, GadW, GadX, GalR, GalS, GatR, GcvA, GlaR, GlcC, GlpR, GlrR, GntR, GutM, H-NS, HU, HdfR, HipB, HprR, HyfR, HypT, IHF, IclR, IdnR, LacI, LeuO, LexA, LrhA, Lrp, LsrR, MalI, MalT, MarA, MarR, MatA, McbR, MelR, MetJ, MhpR, Mlc, MlrA, ModE, MprA, MqsA, MurR, Nac, NadR, NagC, NanR, NarL, NarP, NrdR, NsrR, NtrC, OmpR, OxyR, PaaX, PdhR, PhoB, PhoP, PrpR, PurR, PuuR, QseB, RbsR, RcdA, RcsAB, RcsB, RcsB-BglJ, RhaR, RhaS, Rob, RstA, SdiA, SlyA, SoxR, SoxS, SrlR, StpA, TdcA, TdcR, TorR, TreR, UhpA, UidR, UlaR, UvrY, UxuR, XylR, YdeO, YiaJ, YjjQ, ZraR, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
GalS Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class Sensing external and internal signals
Synonym(s): DNA-binding transcriptional dual regulator GalS, MglD
Gene name(s): galS
Functional conformation(s): GalS-β-D-galactose , GalS
Coregulator(s): CRP, FlhDC, GalR, GalS, H-NS, HU, NagC
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
GalR Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class Sensing external and internal signals
Synonym(s): DNA-binding transcriptional dual regulator GalR
Gene name(s): galR
Functional conformation(s): GalR-β-D-galactose , GalR
Coregulator(s): CRP, FlhDC, GalR, GalS, H-NS, HU, NagC
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
HU      Tractordb tool
Connectivity class Local Regulator
Synonym(s): DNA-binding transcriptional dual regulator HU, HUalpha;beta;
Gene name(s): hupB, hupA
Functional conformation(s): HU
Coregulator(s): AcrR, CRP, GalR, GalS, H-NS, HU, IHF, Lrp, MarA, OmpR, Rob, SoxS, TrpR, TyrR
Summary: TF Summary ...[more]

REGULATION EXERTED BY CRP,GalR,GalS,HU Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
CRP repressor GalR dual GalS dual HU repressor    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
GalS-β-D-galactose activator galEp2 galM , galK , galT , galE 792134 792149 -55.5 gctaaattctTGTGTAAACGATTCCACtaatttattc   [1]
GalS repressor galEp2 galM , galK , galT , galE 792134 792149 -55.5 gctaaattctTGTGTAAACGATTCCACtaatttattc   [1]
GalS repressor galEp2 galM , galK , galT , galE 792022 792037 57.5 ttctggttacCGGTGGTAGCGGTTACAttggaagtca    
HU repressor galEp2 galM , galK , galT , galE 792064 792097 6.5 gcatctttgtTATGCTATGGTTATTTCATACCATAAGCCTAATGGagcgaattat   [2]
[3]
[4]
[5]
CRP-cAMP repressor galEp2 galM , galK , galT , galE 792112 792133 -36.5 aacgattccaCTAATTTATTCCATGTCACACTTttcgcatctt    
GalR repressor galEp2 galM , galK , galT , galE 792028 792043 51.5 tgagagttctGGTTACCGGTGGTAGCGgttacattgg   [3]
[4]
[6]
GalR repressor galEp2 galM , galK , galT , galE 792134 792149 -55.5 gctaaattctTGTGTAAACGATTCCACtaatttattc   [3]
[4]
[6]
GalR-β-D-galactose activator galEp2 galM , galK , galT , galE 792134 792149 -55.5 gctaaattctTGTGTAAACGATTCCACtaatttattc   [3]
[4]
[6]

Reference(s): [1] Geanacopoulos M., et al., 1997
[2] Aki T., et al., 1997
[3] Lia G., et al., 2003
[4] Lyubchenko YL., et al., 1997
[5] Perez N., et al., 2000
[6] Semsey S., et al., 2004



Reference(s)    

 [1] Geanacopoulos M., Adhya S., 1997, Functional characterization of roles of GalR and GalS as regulators of the gal regulon., J Bacteriol 179(1):228-34

 [2] Aki T., Adhya S., 1997, Repressor induced site-specific binding of HU for transcriptional regulation., EMBO J 16(12):3666-74

 [3] Lia G., Bensimon D., Croquette V., Allemand JF., Dunlap D., Lewis DE., Adhya S., Finzi L., 2003, Supercoiling and denaturation in Gal repressor/heat unstable nucleoid protein (HU)-mediated DNA looping., Proc Natl Acad Sci U S A 100(20):11373-7

 [4] Lyubchenko YL., Shlyakhtenko LS., Aki T., Adhya S., 1997, Atomic force microscopic demonstration of DNA looping by GalR and HU., Nucleic Acids Res 25(4):873-6

 [5] Perez N., Rehault M., Amouyal M., 2000, A functional assay in Escherichia coli to detect non-assisted interaction between galactose repressor dimers., Nucleic Acids Res 28(18):3600-4

 [6] Semsey S., Tolstorukov MY., Virnik K., Zhurkin VB., Adhya S., 2004, DNA trajectory in the Gal repressosome., Genes Dev 18(15):1898-907


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