RegulonDB RegulonDB 10.9: Regulon Form
   
   


MetJ regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
MetJ Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class Using internal synthesized signals
Synonym(s): B3938, MetJ, MetJ-SAM
Gene name(s): metJ
Functional conformation(s): MetJ-S-adenosyl-L-methionine , MetJ-adenine , MetJ-MTA , MetJ
Coregulator(s): CRP, HypT, MetJ, MetR, OxyR, PhoP
Summary: TF Summary ...[more]

REGULATION EXERTED BY MetJ Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
MetJ repressor    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
MetJ-S-adenosyl-L-methionine repressor metAp1 metA 4214229 4214244 4.5 ggttatcttcAGCTATCTGGATGTCTAaacgtataag   [1]
[2]
MetJ-S-adenosyl-L-methionine repressor metAp1 metA 4214245 4214260 20.5 ctggatgtctAAACGTATAAGCGTATGtagtgaggta   [1]
[2]
MetJ-S-adenosyl-L-methionine repressor metFp metF 4132555 4132570 17.5 acatctggacGTCTAAACGGATAGATGtgcacaacac   [1]
MetJ-S-adenosyl-L-methionine repressor metFp metF 4132545 4132560 7.5 cttcatctttACATCTGGACGTCTAAAcggatagatg   [1]
MetJ-S-adenosyl-L-methionine repressor metFp metF 4132547 4132562 9.5 tcatctttacATCTGGACGTCTAAACGgatagatgtg   [1]
MetJ-S-adenosyl-L-methionine repressor metFp metF 4132539 4132554 2.0 cttttccttcATCTTTACATCTGGACGtctaaacgga   [1]
MetJ-S-adenosyl-L-methionine repressor metFp metF 4132530 4132545 -8.5 gcccttcggcTTTTCCTTCATCTTTACatctggacgt    
MetJ-S-adenosyl-L-methionine repressor metFp metF 4132542 4132557 4.5 ttccttcatcTTTACATCTGGACGTCTaaacggatag    
MetJ-S-adenosyl-L-methionine repressor metFp metF 4132558 4132573 20.5 tctggacgtcTAAACGGATAGATGTGCacaacacaac    
MetJ-S-adenosyl-L-methionine repressor folEp yeiB , folE 2243816 2243831 25.5 ctttcacttcCGTATTTGCATAACGATgttttaacat   [2]
MetJ-S-adenosyl-L-methionine repressor folEp yeiB , folE 2243808 2243823 33.5 tccgtatttgCATAACGATGTTTTAACatctgctgat   [2]
MetJ-S-adenosyl-L-methionine repressor folEp yeiB , folE 2243800 2243815 41.5 tgcataacgaTGTTTTAACATCTGCTGatgaaaggca   [2]
MetJ-S-adenosyl-L-methionine repressor folEp yeiB , folE 2243792 2243807 49.5 gatgttttaaCATCTGCTGATGAAAGGcagcggcaat   [2]
MetJ-S-adenosyl-L-methionine repressor metCp metC

Reference(s): [1] Liu R., et al., 2001
[2] Marincs F., et al., 2006



Reference(s)    

 [1] Liu R., Blackwell TW., States DJ., 2001, Conformational model for binding site recognition by the E.coli MetJ transcription factor., Bioinformatics 17(7):622-33

 [2] Marincs F., Manfield IW., Stead JA., McDowall KJ., Stockley PG., 2006, Transcript analysis reveals an extended regulon and the importance of protein-protein co-operativity for the Escherichia coli methionine repressor., Biochem J 396(2):227-34

 [3] Otsuka J., Watanabe H., Mori KT., 1996, Evolution of transcriptional regulation system through promiscuous coupling of regulatory proteins with operons; suggestion from protein sequence similarities in Escherichia coli., J Theor Biol 178(2):183-204

 [4] Wild CM., McNally T., Phillips SE., Stockley PG., 1996, Effects of systematic variation of the minimal Escherichia coli met consensus operator site: in vivo and in vitro met repressor binding., Mol Microbiol 21(6):1125-35


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