RegulonDB RegulonDB 10.9: Regulon Form
   
   


TrpR regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
TrpR Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class Sensing external and internal signals
Synonym(s): DNA-binding transcriptional repressor TrpR, RtrY
Gene name(s): trpR
Functional conformation(s): rpR-L-tryptophan , TrpR
Coregulator(s): HU, IHF, TrpR, TyrR
Summary: TF Summary ...[more]

REGULATION EXERTED BY TrpR Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
TrpR repressor    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
rpR-L-tryptophan repressor aroHp1 aroH 1788280 1788297 -29.5 atgtactagaGAACTAGTGCATTAGCTTAtttttttgtt   [1]
[2]
[3]
[4]
[5]
rpR-L-tryptophan repressor aroHp1 aroH 1788272 1788289 -37.5 gtcgccgaatGTACTAGAGAACTAGTGCAttagcttatt   [1]
[2]
[3]
[4]
[5]
rpR-L-tryptophan repressor trpLp trpA , trpB , trpC , trpD , trpE , trpL 1323119 1323136 -19.5 ctgttgacaaTTAATCATCGAACTAGTTAactagtacgc   [2]
[3]
[4]
[5]
rpR-L-tryptophan repressor trpLp trpA , trpB , trpC , trpD , trpE , trpL 1323103 1323120 -3.5 atcgaactagTTAACTAGTACGCAAGTTCacgtaaaaag   [2]
[3]
[4]
[5]
rpR-L-tryptophan repressor trpLp trpA , trpB , trpC , trpD , trpE , trpL 1323111 1323128 -11.5 aattaatcatCGAACTAGTTAACTAGTACgcaagttcac   [2]
[3]
[4]
[5]
rpR-L-tryptophan repressor trpRp trpR 4632695 4632712 -0.5 atatgctatcGTACTCTTTAGCGAGTACAaccgggggag   [6]
[2]
[3]
[4]
[5]

Reference(s): [1] Grove CL., et al., 1987
[2] Jeeves M., et al., 1999
[3] Klig LS., et al., 1988
[4] Kumamoto AA., et al., 1987
[5] Yang J., et al., 1996
[6] Gunsalus RP., et al., 1980



Reference(s)    

 [1] Grove CL., Gunsalus RP., 1987, Regulation of the aroH operon of Escherichia coli by the tryptophan repressor., J Bacteriol 169(5):2158-64

 [2] Jeeves M., Evans PD., Parslow RA., Jaseja M., Hyde EI., 1999, Studies of the Escherichia coli Trp repressor binding to its five operators and to variant operator sequences., Eur J Biochem 265(3):919-28

 [3] Klig LS., Carey J., Yanofsky C., 1988, trp repressor interactions with the trp aroH and trpR operators. Comparison of repressor binding in vitro and repression in vivo., J Mol Biol 202(4):769-77

 [4] Kumamoto AA., Miller WG., Gunsalus RP., 1987, Escherichia coli tryptophan repressor binds multiple sites within the aroH and trp operators., Genes Dev 1(6):556-64

 [5] Yang J., Gunasekera A., Lavoie TA., Jin L., Lewis DE., Carey J., 1996, In vivo and in vitro studies of TrpR-DNA interactions., J Mol Biol 258(1):37-52

 [6] Gunsalus RP., Yanofsky C., 1980, Nucleotide sequence and expression of Escherichia coli trpR, the structural gene for the trp aporepressor., Proc Natl Acad Sci U S A 77(12):7117-21


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