RegulonDB RegulonDB 10.9: Regulon Form
   
   


MetJ,OxyR regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
OxyR Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class Using internal synthesized signals
Synonym(s): DNA-binding transcriptional dual regulator OxyR, MomR, Mor, bifunctional regulatory protein sensor for oxidative stress
Gene name(s): oxyR
Functional conformation(s): OxyR
Coregulator(s): CRP, DksA, ExuR, FNR, Fis, Fur, H-NS, IHF, IscR, MarA, MetJ, MetR, MntR, NarL, NarP, NsrR, OxyR, Rob, SoxS, UxuR, YdcI, Zur, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
MetJ Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class Using internal synthesized signals
Synonym(s): B3938, MetJ, MetJ-SAM
Gene name(s): metJ
Functional conformation(s): MetJ-S-adenosyl-L-methionine , MetJ-adenine , MetJ-MTA , MetJ
Coregulator(s): CRP, HypT, MetJ, MetR, OxyR, PhoP
Summary: TF Summary ...[more]

REGULATION EXERTED BY MetJ,OxyR Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
MetJ repressor OxyR activator    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
OxyR activator ahpCp ahpC , ahpF 638869 638885 -44.0 ttatcgatttGATAATGGAAACGCATTAgccgaatcgg   [1]
[2]
[3]
[4]
[5]
[6]
MetJ-S-adenosyl-L-methionine repressor ahpCp ahpC , ahpF 638940 638955 27.5 acggaggaagTATAGATGTCCTTGATTaacaccaaaa   [7]
MetJ-S-adenosyl-L-methionine repressor ahpCp ahpC , ahpF 638930 638945 17.5 catcgaaaacACGGAGGAAGTATAGATgtccttgatt   [7]
OxyR activator ahpCp ahpC , ahpF 638847 638863 -66.0 tacgaaggttGTAAGGTAAAACTTATCGatttgataat   [1]
[3]
[4]
[5]
[6]

Reference(s): [1] Campos E., et al., 2007
[2] Storz G., et al., 1990
[3] Tartaglia LA., et al., 1992
[4] Tartaglia LA., et al., 1989
[5] Toledano MB., et al., 1994
[6] Zheng M., et al., 2001
[7] Liu R., et al., 2001



Reference(s)    

 [1] Campos E., Montella C., Garces F., Baldoma L., Aguilar J., Badia J., 2007, Aerobic L-ascorbate metabolism and associated oxidative stress in Escherichia coli., Microbiology 153(Pt 10):3399-408

 [2] Storz G., Tartaglia LA., Ames BN., 1990, Transcriptional regulator of oxidative stress-inducible genes: direct activation by oxidation., Science 248(4952):189-94

 [3] Tartaglia LA., Gimeno CJ., Storz G., Ames BN., 1992, Multidegenerate DNA recognition by the OxyR transcriptional regulator., J Biol Chem 267(3):2038-45

 [4] Tartaglia LA., Storz G., Ames BN., 1989, Identification and molecular analysis of oxyR-regulated promoters important for the bacterial adaptation to oxidative stress., J Mol Biol 210(4):709-19

 [5] Toledano MB., Kullik I., Trinh F., Baird PT., Schneider TD., Storz G., 1994, Redox-dependent shift of OxyR-DNA contacts along an extended DNA-binding site: a mechanism for differential promoter selection., Cell 78(5):897-909

 [6] Zheng M., Wang X., Doan B., Lewis KA., Schneider TD., Storz G., 2001, Computation-directed identification of OxyR DNA binding sites in Escherichia coli., J Bacteriol 183(15):4571-9

 [7] Liu R., Blackwell TW., States DJ., 2001, Conformational model for binding site recognition by the E.coli MetJ transcription factor., Bioinformatics 17(7):622-33


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