RegulonDB RegulonDB 10.9: Regulon Form
   
   


Ada,AidB,Lrp regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
Lrp Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class Sensing external and internal signals
Synonym(s): AlsB, DNA-binding transcriptional dual regulator Lrp, Ihb, LivR, Lrs, Lss, LstR, Mbf, OppI, RblA
Gene name(s): lrp
Functional conformation(s): Lrp-L-leucine , Lrp
Coregulator(s): AcrR, Ada, AdiY, AidB, ArcA, ArgP, ArgR, CRP, CadC, CpxR, Cra, DksA, DksA-ppGpp, EnvY, FNR, Fis, FliZ, Fur, GadE, GadE-RcsB, GadW, GadX, GcvA, GlaR, H-NS, HU, HdfR, IHF, LrhA, Lrp, MarA, Mlc, ModE, Nac, NarL, NhaR, NsrR, OmpR, PhoP, PurR, QseB, RcsB, Rob, SoxS, StpA, TorR, YeiL, YjjQ, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
Ada      Tractordb tool
Connectivity class Local Regulator
Sensing Class Using internal synthesized signals
Synonym(s): DNA-binding transcriptional dual regulator / DNA repair protein Ada
Gene name(s): ada
Functional conformation(s): Ada , Ada-Methylated
Coregulator(s): Ada, AidB, Lrp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
AidB      Tractordb tool
Connectivity class Local Regulator
Synonym(s): isovaleryl-CoA dehydrogenase and DNA-binding transcriptional repressor, putative acyl-CoA dehydrogenase AidB
Gene name(s): aidB
Functional conformation(s): AidB-isovaleryl-CoA
Coregulator(s): Ada, AidB, Lrp
Summary: TF Summary ...[more]

REGULATION EXERTED BY Ada,AidB,Lrp Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
Ada activator AidB repressor Lrp repressor    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
Ada activator aidBp aidB 4414182 4414206 -53.5 cgcattacatTGCTGGATAAGAATGTTTTAGCAATctctttctgt   [1]
[2]
[3]
AidB-isovaleryl-CoA repressor aidBp aidB 4414186 4414212 -48.0 ttacattgctGGATAAGAATGTTTTAGCAATCTCTTTctgtcatgaa   [4]
Lrp repressor aidBp aidB

Reference(s): [1] Landini P., et al., 1995
[2] Landini P., et al., 1995
[3] Volkert MR., et al., 1994
[4] Rippa V., et al., 2010



Reference(s)    

 [1] Landini P., Volkert MR., 1995, RNA polymerase alpha subunit binding site in positively controlled promoters: a new model for RNA polymerase-promoter interaction and transcriptional activation in the Escherichia coli ada and aidB genes., EMBO J 14(17):4329-35

 [2] Landini P., Volkert MR., 1995, Transcriptional activation of the Escherichia coli adaptive response gene aidB is mediated by binding of methylated Ada protein. Evidence for a new consensus sequence for Ada-binding sites., J Biol Chem 270(14):8285-9

 [3] Volkert MR., Hajec LI., Matijasevic Z., Fang FC., Prince R., 1994, Induction of the Escherichia coli aidB gene under oxygen-limiting conditions requires a functional rpoS (katF) gene., J Bacteriol 176(24):7638-45

 [4] Rippa V., Amoresano A., Esposito C., Landini P., Volkert M., Duilio A., 2010, Specific DNA binding and regulation of its own expression by the AidB protein in Escherichia coli., J Bacteriol 192(23):6136-42

 [5] Landini P., Hajec LI., Nguyen LH., Burgess RR., Volkert MR., 1996, The leucine-responsive regulatory protein (Lrp) acts as a specific repressor for sigma s-dependent transcription of the Escherichia coli aidB gene., Mol Microbiol 20(5):947-55


RegulonDB