RegulonDB RegulonDB 10.9: Regulon Form
   
   


CRP,UhpA,UvrY regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
CRP Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class Using internal synthesized signals
Synonym(s): Cap, Csm, DNA-binding transcriptional dual regulator CRP, GurB
Gene name(s): crp
Functional conformation(s): CRP-cAMP , CRP
Coregulator(s): AcrR, AdiY, AgaR, AraC, ArcA, ArgP, ArgR, AscG, BasR, BolA, BtsR, CRP, CRP-Sxy, CaiF, ChbR, ComR, CpxR, Cra, CreB, CsgD, CspA, CsqR, CusR, CytR, DcuR, DeoR, DgoR, DksA-ppGpp, DnaA, DpiA, DsdC, EbgR, EnvY, EvgA, ExuR, FNR, FadR, FeaR, FhlA, Fis, FlhDC, FliZ, FucR, Fur, GadE, GadE-RcsB, GadW, GadX, GalR, GalS, GatR, GcvA, GlaR, GlcC, GlpR, GlrR, GntR, GutM, H-NS, HU, HdfR, HipB, HprR, HyfR, HypT, IHF, IclR, IdnR, LacI, LeuO, LexA, LrhA, Lrp, LsrR, MalI, MalT, MarA, MarR, MatA, McbR, MelR, MetJ, MhpR, Mlc, MlrA, ModE, MprA, MqsA, MurR, Nac, NadR, NagC, NanR, NarL, NarP, NrdR, NsrR, NtrC, OmpR, OxyR, PaaX, PdhR, PhoB, PhoP, PrpR, PurR, PuuR, QseB, RbsR, RcdA, RcsAB, RcsB, RcsB-BglJ, RhaR, RhaS, Rob, RstA, SdiA, SlyA, SoxR, SoxS, SrlR, StpA, TdcA, TdcR, TorR, TreR, UhpA, UidR, UlaR, UvrY, UxuR, XylR, YdeO, YiaJ, YjjQ, ZraR, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
UvrY      Tractordb tool
Connectivity class Local Regulator
Sensing Class External-Two-component systems
Synonym(s): DNA-binding transcriptional activator UvrY, UvrY response regulator, YecB
Gene name(s): uvrY
Functional conformation(s): UvrY-phosphorylated , UvrY
Coregulator(s): CRP, EvgA, H-NS, IHF, NagC, NarL, NarP, PhoP, RcsB, UhpA, UvrY
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
UhpA      Tractordb tool
Connectivity class Local Regulator
Sensing Class External-Two-component systems
Synonym(s): DNA-binding transcriptional activator UhpA, UhpA response regulator
Gene name(s): uhpA
Functional conformation(s): UhpA-phosphorylated , UhpA
Coregulator(s): CRP, UhpA, UvrY
Summary: TF Summary ...[more]

REGULATION EXERTED BY CRP,UhpA,UvrY Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
CRP activator UhpA activator UvrY activator    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
CRP-cAMP activator uhpTp uhpT 3847291 3847312 -103.5 gacaccgcgcGAAGCGTGATGCATCTCACCTTTtcacttcata   [1]
UhpA-phosphorylated activator uhpTp uhpT 3847253 3847272 -64.5 atatccggcaAAACTAAGAAATTTTCCAGGTtttgcctgga   [2]
[3]
[4]
UhpA-phosphorylated activator uhpTp uhpT 3847230 3847249 -41.5 ttccaggtttTGCCTGGACGCTATCTCAGGCctgatttgct   [3]
[5]
[1]
[6]
UvrY-phosphorylated activator uhpTp uhpT

Reference(s): [1] Olekhnovich IN., et al., 2002
[2] Chen Q., et al., 2000
[3] Dahl JL., et al., 1997
[4] Wright JS., et al., 2000
[5] Olekhnovich IN., et al., 1999
[6] Verhamme DT., et al., 2002



Reference(s)    

 [1] Olekhnovich IN., Kadner RJ., 2002, Mutational scanning and affinity cleavage analysis of UhpA-binding sites in the Escherichia coli uhpT promoter., J Bacteriol 184(10):2682-91

 [2] Chen Q., Kadner RJ., 2000, Effect of altered spacing between uhpT promoter elements on transcription activation., J Bacteriol 182(16):4430-6

 [3] Dahl JL., Wei BY., Kadner RJ., 1997, Protein phosphorylation affects binding of the Escherichia coli transcription activator UhpA to the uhpT promoter., J Biol Chem 272(3):1910-9

 [4] Wright JS., Olekhnovich IN., Touchie G., Kadner RJ., 2000, The histidine kinase domain of UhpB inhibits UhpA action at the Escherichia coli uhpT promoter., J Bacteriol 182(22):6279-86

 [5] Olekhnovich IN., Dahl JL., Kadner RJ., 1999, Separate contributions of UhpA and CAP to activation of transcription of the uhpT promoter of Escherichia coli., J Mol Biol 292(5):973-86

 [6] Verhamme DT., Postma PW., Crielaard W., Hellingwerf KJ., 2002, Cooperativity in signal transfer through the Uhp system of Escherichia coli., J Bacteriol 184(15):4205-10

 [7] Yoshida M., Ishihama A., Yamamoto K., 2015, Cross talk in promoter recognition between six NarL-family response regulators of Escherichia coli two-component system., Genes Cells 20(7):601-12


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