RegulonDB RegulonDB 10.9: Regulon Form
   
   


CspA,Fis,GadX,H-NS regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
Fis      Tractordb tool
Connectivity class Global Regulator
Sensing Class TFs for DNA-bending
Synonym(s): DNA-binding transcriptional dual regulator Fis, Nbp, site-specific DNA inversion stimulation factor
Gene name(s): fis
Functional conformation(s): Fis
Coregulator(s): AcrR, AdiY, AppY, ArcA, ArgP, BasR, CRP, CpxR, Cra, CreB, CspA, CusR, CytR, DeoR, DksA, DksA-ppGpp, DnaA, FNR, FadR, Fis, FlhDC, FliZ, Fur, GadE, GadE-RcsB, GadW, GadX, GlcC, GlpR, H-NS, HprR, IHF, IscR, LeuO, Lrp, MalT, MarA, MarR, MazE, MazE-MazF, Mlc, MntR, ModE, NanR, NarL, NarP, NrdR, NsrR, NtrC, OmpR, OxyR, PdhR, PepA, PurR, RcsB, RcsB-BglJ, Rob, RstA, RutR, SlyA, SoxS, StpA, TorR, XylR, YdeO, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
H-NS      Tractordb tool
Connectivity class Global Regulator
Synonym(s): BglY, Cur, DNA-binding protein HLP-II (HU, BH2, HD, NS), DNA-binding transcriptional dual regulator H-NS, Drc, DrdX, Drs, FimG, Hns, HnsA, Irk, MsyA, OsmZ, PilG, TopS, TopX, VirR
Gene name(s): hns
Functional conformation(s): H-NS
Coregulator(s): AcrR, AdiY, ArcA, ArgP, ArgR, BasR, BolA, BtsR, CRP, CadC, CaiF, CdaR, CpxR, Cra, CreB, CsgD, CspA, CysB, DksA, DksA-ppGpp, DnaA, DpiA, EvgA, FNR, Fis, FlhDC, FliZ, Fur, GadE, GadE-RcsB, GadW, GadX, GalR, GalS, GlaR, GutM, H-NS, HU, HdfR, HypT, IHF, LacI, LeuO, LrhA, Lrp, MalT, MarA, MatA, McbR, MlrA, MntR, MqsA, NagC, NanR, NarL, NarP, NhaR, NrdR, NsrR, OmpR, OxyR, PhoB, PhoP, QseB, RcdA, RcsAB, RcsB, RcsB-BglJ, Rob, RstA, RutR, SdiA, SlyA, SoxS, SrlR, StpA, SutR, TorR, UvrY, YdeO, YjjQ, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
GadX      Tractordb tool
Connectivity class Local Regulator
Synonym(s): DNA-binding transcriptional dual regulator GadX, YhiX
Gene name(s): gadX
Functional conformation(s): GadX
Coregulator(s): AdiY, AraC, ArcA, CRP, CadC, CspA, EvgA, FNR, Fis, FliZ, Fur, GadE, GadE-RcsB, GadW, GadX, H-NS, Lrp, MarA, MqsA, NagC, NtrC, OmpR, PhoB, PhoP, RcsB, RutR, SdiA, TorR, YdeO, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
CspA      Tractordb tool
Connectivity class Local Regulator
Synonym(s): CS7.4, DNA-binding transcriptional activator CspA, F10.6, cold shock protein CspA, major cold shock protein 7.4
Gene name(s): cspA
Functional conformation(s): CspA
Coregulator(s): CRP, CspA, Fis, GadX, H-NS
Summary: TF Summary ...[more]

REGULATION EXERTED BY CspA,Fis,GadX,H-NS Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
CspA activator Fis activator GadX activator H-NS repressor    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
H-NS repressor hnsp hns 1293133 1293147 -182.0 ccccataaaaTGTGACATGAATCAGGaagttttaac   [1]
[2]
[3]
H-NS repressor hnsp hns 1293064 1293078 -113.0 gctatatgccGCGTCTTTTCTGGCTAattttatgaa   [1]
[2]
[3]
H-NS repressor hnsp hns 1292991 1293005 -40.0 tgaattccttACATTCCTGGCTATTGcacaactgaa   [1]
[3]
Fis activator hnsp hns 1293022 1293036 -71.0 tttattggcgGCACAAAATAAAGAACaattttgaat   [1]
Fis activator hnsp hns 1293125 1293139 -174.0 aatgtgacatGAATCAGGAAGTTTTAacctcacgtg   [1]
Fis activator hnsp hns 1293233 1293247 -282.0 cttattgcgaCTGTTCTACTTTTCATcattcgctta   [1]
Fis activator hnsp hns 1293194 1293208 -243.0 gggaattctcGTAAACACAACTAATAcagaagactg   [1]
Fis activator hnsp hns 1293069 1293083 -118.0 atagggctatATGCCGCGTCTTTTCTggctaatttt   [1]
Fis activator hnsp hns 1292961 1292975 -10.0 actgaatttaAGGCTCTATTATTACCtcaacaaacc   [1]
Fis activator hnsp hns 1292927 1292941 25.0 ccaccccaatATAAGTTTGAGATTACtacaatgagc   [1]
GadX activator hnsp hns

Reference(s): [1] Falconi M., et al., 1996
[2] Falconi M., et al., 1993
[3] Ueguchi C., et al., 1993



Reference(s)    

 [1] Falconi M., Brandi A., La Teana A., Gualerzi CO., Pon CL., 1996, Antagonistic involvement of FIS and H-NS proteins in the transcriptional control of hns expression., Mol Microbiol 19(5):965-75

 [2] Falconi M., Higgins NP., Spurio R., Pon CL., Gualerzi CO., 1993, Expression of the gene encoding the major bacterial nucleotide protein H-NS is subject to transcriptional auto-repression., Mol Microbiol 10(2):273-82

 [3] Ueguchi C., Kakeda M., Mizuno T., 1993, Autoregulatory expression of the Escherichia coli hns gene encoding a nucleoid protein: H-NS functions as a repressor of its own transcription., Mol Gen Genet 236(2-3):171-8

 [4] Hommais F., Krin E., Coppee JY., Lacroix C., Yeramian E., Danchin A., Bertin P., 2004, GadE (YhiE): a novel activator involved in the response to acid environment in Escherichia coli., Microbiology 150(Pt 1):61-72

 [5] Giangrossi M., Gualerzi CO., Pon CL., 2001, Mutagenesis of the downstream region of the Escherichia coli hns promoter., Biochimie 83(2):251-9


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