RegulonDB RegulonDB 10.9: Regulon Form
   
   


FhlA,IHF,ModE,NsrR regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
ModE Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class External sensing using transported metabolites
Synonym(s): ChlD, DNA-binding transcriptional dual regulator ModE, ModE-MoO42-, ModR
Gene name(s): modE
Functional conformation(s): ModE-MoO42- , ModE
Coregulator(s): ArcA, CRP, CytR, DeoR, FNR, FhlA, Fis, FlhDC, Fur, IHF, Lrp, ModE, NarL, NarP, NsrR
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
FhlA Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class Using internal synthesized signals
Synonym(s): DNA-binding transcriptional activator FhlA, Fhl, formate hydrogen-lyase transcriptional activator for fdhF, hyc and hyp operons
Gene name(s): fhlA
Functional conformation(s): FhlA-formate , FhlA
Coregulator(s): CRP, FNR, FhlA, FlhDC, HyfR, IHF, ModE, NarL, NarP, NsrR
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
NsrR Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Synonym(s): DNA-binding transcriptional repressor NsrR, YjeB
Gene name(s): nsrR
Functional conformation(s): NsrR-nitric oxide , NsrR , NsrR-[2Fe-2S]2+ oxidized , NsrR-[2Fe-2S]reduced
Coregulator(s): ArcA, CRP, CpxR, CsgD, CytR, DksA, DksA-ppGpp, DsdC, FNR, FeaR, FhlA, Fis, FlhDC, Fur, GadE, H-NS, IHF, IscR, Lrp, MatA, MetR, ModE, Nac, NarL, NarP, NorR, NsrR, OxyR, PdhR, PhoB, QseB, SutR, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
IHF Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Synonym(s): DNA-binding transcriptional dual regulator IHF
Gene name(s): ihfB, ihfA
Functional conformation(s): IHF
Coregulator(s): AcrR, AdiY, ArcA, ArgR, AtoC, BasR, BolA, BtsR, CRP, Cbl, CpxR, Cra, CsgD, CysB, DksA, DksA-ppGpp, EnvY, FNR, FadR, FhlA, Fis, FlhDC, FliZ, Fur, GadE, GlcC, GlpR, GlrR, H-NS, HU, HdfR, HipAB, HipB, IHF, IclR, IscR, LrhA, Lrp, MarA, MatA, MlrA, MntR, ModE, MprA, MqsA, Nac, NagC, NanR, NarL, NarP, NorR, NsrR, NtrC, OmpR, OxyR, PaaX, PdhR, PepA, PhoB, PspF, PurR, QseB, RcdA, RcsAB, Rob, RstA, RtcR, RutR, SlyA, SoxR, SoxS, SutR, TdcA, TdcR, TrpR, TyrR, UlaR, UvrY, YeiL, YiaJ, YjjQ, ppGpp
Summary: TF Summary ...[more]

REGULATION EXERTED BY FhlA,IHF,ModE,NsrR Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
FhlA activator IHF activator ModE activator NsrR repressor    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
ModE-MoO42- activator hycAp hycI , hycH , hycG , hycF , hycE , hycD , hycC , hycB , hycA 2850641 2850664 -192.0 gcccgttggcAGAGGGTTATTTCGTGCATATCGCCtcccattaac   [1]
FhlA-formate activator hycAp hycI , hycH , hycG , hycF , hycE , hycD , hycC , hycB , hycA 2850553 2850566 -98.0 aatgtcgatgATGTCGAAATGACAcgtcgacacg   [2]
[3]
[4]
[5]
IHF activator hycAp hycI , hycH , hycG , hycF , hycE , hycD , hycC , hycB , hycA 2850493 2850505 -38.5 aatctctttaATAACAATAAATTAaaagttggca   [2]
FhlA-formate activator hycAp hycI , hycH , hycG , hycF , hycE , hycD , hycC , hycB , hycA 2850539 2850552 -84.5 tcgaaatgacACGTCGACACGGCGAcgaaattcat   [2]
[3]
[4]
NsrR repressor hycAp hycI , hycH , hycG , hycF , hycE , hycD , hycC , hycB , hycA 2850526 2850537 -70.0 acacggcgacGAAATTCATCTTtagcttaaaa   [6]

Reference(s): [1] Self WT., et al., 1999
[2] Hopper S., et al., 1994
[3] Leonhartsberger S., et al., 2000
[4] Schlensog V., et al., 1994
[5] Self WT., et al., 2000
[6] Partridge JD., et al., 2009



Reference(s)    

 [1] Self WT., Grunden AM., Hasona A., Shanmugam KT., 1999, Transcriptional regulation of molybdoenzyme synthesis in Escherichia coli in response to molybdenum: ModE-molybdate, a repressor of the modABCD (molybdate transport) operon is a secondary transcriptional activator for the hyc and nar operons., Microbiology 145 ( Pt 1):41-55

 [2] Hopper S., Babst M., Schlensog V., Fischer HM., Hennecke H., Bock A., 1994, Regulated expression in vitro of genes coding for formate hydrogenlyase components of Escherichia coli., J Biol Chem 269(30):19597-604

 [3] Leonhartsberger S., Ehrenreich A., Bock A., 2000, Analysis of the domain structure and the DNA binding site of the transcriptional activator FhlA., Eur J Biochem 267(12):3672-84

 [4] Schlensog V., Lutz S., Bock A., 1994, Purification and DNA-binding properties of FHLA, the transcriptional activator of the formate hydrogenlyase system from Escherichia coli., J Biol Chem 269(30):19590-6

 [5] Self WT., Shanmugam KT., 2000, Isolation and characterization of mutated Fh1A proteins which activate transcription of the hyc operon (formate hydrogenlyase) of Escherichia coli in the absence of molybdate(1)., FEMS Microbiol Lett 184(1):47-52

 [6] Partridge JD., Bodenmiller DM., Humphrys MS., Spiro S., 2009, NsrR targets in the Escherichia coli genome: new insights into DNA sequence requirements for binding and a role for NsrR in the regulation of motility., Mol Microbiol 73(4):680-94


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