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MarA,SoxS regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
SoxS Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Synonym(s): DNA-binding transcriptional dual regulator SoxS, regulation of superoxide response regulon
Gene name(s): soxS
Functional conformation(s): SoxS
Coregulator(s): AcrR, ArcA, BasR, CRP, CpxR, Cra, DnaA, EnvR, FNR, Fis, Fur, H-NS, HU, IHF, Lrp, MarA, MarR, Mlc, MprA, NarL, OmpR, OxyR, PhoP, Rob, SoxR, SoxS, Zur
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
MarA Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Synonym(s): CfxB, DNA-binding transcriptional dual regulator MarA, InaR, NfxC, NorB, SoxQ
Gene name(s): marA
Functional conformation(s): MarA
Coregulator(s): AcrR, ArcA, BasR, BluR, CRP, CpxR, Cra, DnaA, EnvR, FNR, Fis, FliZ, Fur, GadE, GadE-RcsB, GadW, GadX, H-NS, HU, IHF, LacI, Lrp, MarA, MarR, MprA, OmpR, OxyR, PhoP, PurR, PutA, RcsB, Rob, SoxR, SoxS, TorR, YdeO
Summary: TF Summary ...[more]

REGULATION EXERTED BY MarA,SoxS Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
MarA activator SoxS activator    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
MarA activator pqiAp1 pqiA , pqiB , pqiC 1011614 1011633 -42.5 cgccgcggcaAAAGCAGAAACTGTAAAACGCagcagtagca   [1]
[2]
SoxS activator pqiAp1 pqiA , pqiB , pqiC 1011616 1011635 -40.0 ccgcggcaaaAGCAGAAACTGTAAAACGCAGcagtagcaaa   [3]
[1]
MarA activator fprp fpr 4114548 4114567 -58.5 catcctctgaTTGATTTGATCGATTGAGCCTtccagtcctt   [4]
SoxS activator fprp fpr 4114546 4114565 -56.5 tcctctgattGATTTGATCGATTGAGCCTTCcagtccttcg   [5]
[1]
[2]
[6]
[7]
MarA activator decRp decR 468277 468296 -65.0 tttttgcgttGAATTTGTCATTTTGTGCCGTggtgtttaaa   [8]
SoxS activator waaYp waaZ , waaY 3801169 3801188 -42.5 tgcaactaaaCCGTGGCACAAATGGGCAATTtatccatcgg   [9]
MarA activator waaYp waaZ , waaY 3801169 3801188 -43.0 tgcaactaaaCCGTGGCACAAATGGGCAATTtatccatcgg   [9]
SoxS activator decRp decR 468279 468298 -63.0 tttgcgttgaATTTGTCATTTTGTGCCGTGGtgtttaaacc   [7]
MarA activator pqiAp3 pqiA , pqiB , pqiC 1011614 1011633 -42.5 cgccgcggcaAAAGCAGAAACTGTAAAACGCagcagtagca   [1]
[2]
SoxS activator pqiAp3 pqiA , pqiB , pqiC 1011616 1011635 -40.0 ccgcggcaaaAGCAGAAACTGTAAAACGCAGcagtagcaaa   [3]
[1]

Reference(s): [1] Martin RG., et al., 1999
[2] Martin RG., et al., 2011
[3] Koh YS., et al., 1996
[4] Gillette WK., et al., 2000
[5] Jair KW., et al., 1995
[6] Pomposiello PJ., et al., 2001
[7] Seo SW., et al., 2015
[8] Rodionov DA., et al., 2001
[9] Lee JH., et al., 2009



Reference(s)    

 [1] Martin RG., Gillette WK., Rhee S., Rosner JL., 1999, Structural requirements for marbox function in transcriptional activation of mar/sox/rob regulon promoters in Escherichia coli: sequence, orientation and spatial relationship to the core promoter., Mol Microbiol 34(3):431-41

 [2] Martin RG., Rosner JL., 2011, Promoter discrimination at class I MarA regulon promoters mediated by glutamic acid 89 of the MarA transcriptional activator of Escherichia coli., J Bacteriol 193(2):506-15

 [3] Koh YS., Roe JH., 1996, Dual regulation of the paraquat-inducible gene pqi-5 by SoxS and RpoS in Escherichia coli., Mol Microbiol 22(1):53-61

 [4] Gillette WK., Martin RG., Rosner JL., 2000, Probing the Escherichia coli transcriptional activator MarA using alanine-scanning mutagenesis: residues important for DNA binding and activation., J Mol Biol 299(5):1245-55

 [5] Jair KW., Martin RG., Rosner JL., Fujita N., Ishihama A., Wolf RE., 1995, Purification and regulatory properties of MarA protein, a transcriptional activator of Escherichia coli multiple antibiotic and superoxide resistance promoters., J Bacteriol 177(24):7100-4

 [6] Pomposiello PJ., Bennik MH., Demple B., 2001, Genome-wide transcriptional profiling of the Escherichia coli responses to superoxide stress and sodium salicylate., J Bacteriol 183(13):3890-902

 [7] Seo SW., Kim D., Szubin R., Palsson BO., 2015, Genome-wide Reconstruction of OxyR and SoxRS Transcriptional Regulatory Networks under Oxidative Stress in Escherichia coli K-12 MG1655., Cell Rep 12(8):1289-99

 [8] Rodionov DA., Gelfand MS., Mironov AA., Rakhmaninova AB., 2001, Comparative approach to analysis of regulation in complete genomes: multidrug resistance systems in gamma-proteobacteria., J Mol Microbiol Biotechnol 3(2):319-24

 [9] Lee JH., Lee KL., Yeo WS., Park SJ., Roe JH., 2009, SoxRS-mediated lipopolysaccharide modification enhances resistance against multiple drugs in Escherichia coli., J Bacteriol 191(13):4441-50


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