RegulonDB RegulonDB 10.9: Regulon Form
   
   


Cra,Fis,Lrp,NarL regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
Fis Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class TFs for DNA-bending
Synonym(s): DNA-binding transcriptional dual regulator Fis, Nbp, site-specific DNA inversion stimulation factor
Gene name(s): fis
Functional conformation(s): Fis
Coregulator(s): AcrR, AdiY, AppY, ArcA, ArgP, BasR, CRP, CpxR, Cra, CreB, CspA, CusR, CytR, DeoR, DksA, DksA-ppGpp, DnaA, FNR, FadR, Fis, FlhDC, FliZ, Fur, GadE, GadE-RcsB, GadW, GadX, GlcC, GlpR, H-NS, HprR, IHF, IscR, LeuO, Lrp, MalT, MarA, MarR, MazE, MazE-MazF, Mlc, MntR, ModE, NanR, NarL, NarP, NrdR, NsrR, NtrC, OmpR, OxyR, PdhR, PepA, PurR, RcsB, RcsB-BglJ, Rob, RstA, RutR, SlyA, SoxS, StpA, TorR, XylR, YdeO, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
Lrp Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class Sensing external and internal signals
Synonym(s): AlsB, DNA-binding transcriptional dual regulator Lrp, Ihb, LivR, Lrs, Lss, LstR, Mbf, OppI, RblA
Gene name(s): lrp
Functional conformation(s): Lrp-leucine , Lrp
Coregulator(s): AcrR, Ada, AdiY, AidB, ArcA, ArgP, ArgR, CRP, CadC, CpxR, Cra, DksA, DksA-ppGpp, EnvY, FNR, Fis, FliZ, Fur, GadE, GadE-RcsB, GadW, GadX, GcvA, GlaR, H-NS, HU, HdfR, IHF, LrhA, Lrp, MarA, Mlc, ModE, Nac, NarL, NhaR, NsrR, OmpR, PhoP, PurR, QseB, RcsB, Rob, SoxS, StpA, TorR, YeiL, YjjQ, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
NarL Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class External-Two-component systems
Synonym(s): DNA-binding transcriptional dual regulator NarL, FrdR, NarR, nitrate/nitrite response regulator NarL
Gene name(s): narL
Functional conformation(s): NarL-Phosphorylated , NarL
Coregulator(s): AppY, ArcA, CRP, Cra, DcuR, DpiA, EvgA, FNR, FhlA, Fis, FlhDC, Fur, H-NS, IHF, IscR, Lrp, ModE, NagC, NarL, NarP, NikR, NorR, NsrR, OxyR, PhoP, RcsB, RstA, SoxS, TorR, UvrY, YdeO
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
Cra Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class Using internal synthesized signals
Synonym(s): DNA-binding transcriptional dual regulator Cra, FruC, FruR, Shl
Gene name(s): cra
Functional conformation(s): Cra , Cra-β-D-fructofuranose 1-phosphate , Cra-β-D-fructose 1,6-bisphosphate , Cra-;-D-fructose 1,6-bisphosphate
Coregulator(s): AcrR, ArcA, BasR, BetI, BolA, BtsR, CRP, CpxR, Cra, CsgD, CusR, DcuR, DksA, FNR, Fis, FliZ, Fur, GadE, GlcC, GntR, H-NS, HprR, IHF, IclR, KdgR, Lrp, MarA, MarR, Mlc, MlrA, MqsA, NagC, NarL, NarP, OmpR, PdhR, PrpR, RcdA, RcsAB, Rob, RstA, SgrR, SoxS, TyrR, ppGpp
Summary: TF Summary ...[more]

REGULATION EXERTED BY Cra,Fis,Lrp,NarL Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
Cra repressor Fis activator Lrp repressor NarL repressor    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
NarL-Phosphorylated repressor adhEp1 adhE 1298321 1298327 90.0 agtacccagaAGTGAGTAatcttgctta   [1]
[2]
NarL-Phosphorylated repressor adhEp1 adhE 1298330 1298336 81.0 cacgtaatcaGTACCCAGaagtgagtaa   [1]
[2]
Cra repressor adhEp1 adhE 1298370 1298386 36.5 cgaaaagcgaTGCTGAAAGGTGTCAGCtttgcaaaaa   [3]
[4]
Fis activator adhEp1 adhE 1298554 1298568 -148.0 agccggataaTGTTAGCCATAAATAAggttgaaaag   [5]
Fis activator adhEp1 adhE 1298474 1298488 -68.0 ctacttaaaaTTGCTATCATTCGTTAttgttatcta   [5]
Fis activator adhEp1 adhE 1298448 1298462 -42.0 ttgttatctaGTTGTGCAAAACATGCtaatgtagcc   [5]
Lrp repressor adhEp1 adhE 1298563 1298578 -157.0 cgaagcaaaaGCCGGATAATGTTAGCcataaataag   [6]
Lrp repressor adhEp1 adhE 1298472 1298485 -65.0 ttaaaattgcTATCATTCGTTATTgttatctagt   [6]
Lrp repressor adhEp1 adhE 1298412 1298427 -6.0 accaaatcatACTACAATTTATTAACtgttagctat   [6]
Lrp repressor adhEp adhE 1298563 1298578 -157.0 cgaagcaaaaGCCGGATAATGTTAGCcataaataag   [6]
Lrp repressor adhEp adhE 1298472 1298485 -65.0 ttaaaattgcTATCATTCGTTATTgttatctagt   [6]
Cra repressor adhEp adhE 1298370 1298386 36.5 cgaaaagcgaTGCTGAAAGGTGTCAGCtttgcaaaaa   [3]
[4]
NarL-Phosphorylated repressor adhEp adhE 1298330 1298336 81.0 cacgtaatcaGTACCCAGaagtgagtaa   [1]
[2]
NarL-Phosphorylated repressor adhEp adhE 1298321 1298327 90.0 agtacccagaAGTGAGTAatcttgctta   [1]
[2]
Lrp repressor adhEp adhE 1298412 1298427 -6.0 accaaatcatACTACAATTTATTAACtgttagctat   [6]
Fis activator adhEp adhE 1298448 1298462 -42.0 ttgttatctaGTTGTGCAAAACATGCtaatgtagcc   [5]
Fis activator adhEp adhE 1298474 1298488 -68.0 ctacttaaaaTTGCTATCATTCGTTAttgttatcta   [5]
Fis activator adhEp adhE 1298554 1298568 -148.0 agccggataaTGTTAGCCATAAATAAggttgaaaag   [5]

Reference(s): [1] Chen YM., et al., 1991
[2] Membrillo-Hernandez J., et al., 1999
[3] Mikulskis A., et al., 1997
[4] Sarkar D., et al., 2008
[5] Membrillo-Hernandez J., et al., 1999
[6] Lintner RE., et al., 2008



Reference(s)    

 [1] Chen YM., Lin EC., 1991, Regulation of the adhE gene, which encodes ethanol dehydrogenase in Escherichia coli., J Bacteriol 173(24):8009-13

 [2] Membrillo-Hernandez J., Lin EC., 1999, Regulation of expression of the adhE gene, encoding ethanol oxidoreductase in Escherichia coli: transcription from a downstream promoter and regulation by fnr and RpoS., J Bacteriol 181(24):7571-9

 [3] Mikulskis A., Aristarkhov A., Lin EC., 1997, Regulation of expression of the ethanol dehydrogenase gene (adhE) in Escherichia coli by catabolite repressor activator protein Cra., J Bacteriol 179(22):7129-34

 [4] Sarkar D., Siddiquee KA., Arauzo-Bravo MJ., Oba T., Shimizu K., 2008, Effect of cra gene knockout together with edd and iclR genes knockout on the metabolism in Escherichia coli., Arch Microbiol 190(5):559-71

 [5] Membrillo-Hernandez J., Kwon O., De Wulf P., Finkel SE., Lin EC., 1999, Regulation of adhE (encoding ethanol oxidoreductase) by the Fis protein in Escherichia coli., J Bacteriol 181(23):7390-3

 [6] Lintner RE., Mishra PK., Srivastava P., Martinez-Vaz BM., Khodursky AB., Blumenthal RM., 2008, Limited functional conservation of a global regulator among related bacterial genera: Lrp in Escherichia, Proteus and Vibrio., BMC Microbiol 8:60


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