RegulonDB RegulonDB 10.9: Regulon Form
   
   


FNR,NarL regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
FNR Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class Using internal synthesized signals
Synonym(s): DNA-binding transcriptional dual regulator FNR, NirA, NirR, OssA, OxrA
Gene name(s): fnr
Functional conformation(s): FNR , FNR-[4Fe-4S]2+ reduced , FNR-[2Fe-2S]2+ oxidized
Coregulator(s): AcrR, AdiY, ArcA, ArgP, ArgR, BtsR, CRP, CadC, CaiF, Cbl, CdaR, Cra, CueR, CusR, CysB, DcuR, DksA, DksA-ppGpp, DnaA, DpiA, EvgA, ExuR, FNR, FhlA, Fis, FlhDC, Fur, GadE, GadE-RcsB, GadW, GadX, GcvA, GlpR, H-NS, HdfR, HprR, HyfR, HypT, IHF, LeuO, Lrp, MalT, MarA, MetR, MlrA, ModE, Nac, NagC, NarL, NarP, NfeR, NikR, NorR, NrdR, NsrR, NtrC, OmpR, OxyR, PdhR, PhoB, PhoP, PurR, PuuR, RcsB, Rob, RstA, RutR, SlyA, SoxR, SoxS, TdcA, TdcR, TorR, YeiL, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
NarL Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class External-Two-component systems
Synonym(s): DNA-binding transcriptional dual regulator NarL, FrdR, NarR, nitrate/nitrite response regulator NarL
Gene name(s): narL
Functional conformation(s): NarL-Phosphorylated , NarL
Coregulator(s): AppY, ArcA, CRP, Cra, DcuR, DpiA, EvgA, FNR, FhlA, Fis, FlhDC, Fur, H-NS, IHF, IscR, Lrp, ModE, NagC, NarL, NarP, NikR, NorR, NsrR, OxyR, PhoP, RcsB, RstA, SoxS, TorR, UvrY, YdeO
Summary: TF Summary ...[more]

REGULATION EXERTED BY FNR,NarL Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
FNR activator NarL repressor    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
NarL-Phosphorylated repressor adhEp2 adhE 1298330 1298336 -24.0 cacgtaatcaGTACCCAGaagtgagtaa   [1]
NarL-Phosphorylated repressor adhEp2 adhE 1298321 1298327 -15.0 agtacccagaAGTGAGTAatcttgctta   [1]
NarL-Phosphorylated repressor focAp3 pflB , focA 954510 954516 302.0 atttctcatcTATAATGCtttgttagta   [2]
NarL-Phosphorylated repressor focAp3 pflB , focA 954527 954533 285.0 agatatgatcTATATCAAtttctcatct   [2]
NarL-Phosphorylated repressor focAp3 pflB , focA 954591 954597 221.0 taatcaaataTTTACTCCgtatttgcat   [2]
NarL-Phosphorylated repressor focAp3 pflB , focA 954642 954648 170.0 cggaaaaaatTCAACTCAtttgttaatt   [2]
NarL-Phosphorylated repressor focAp3 pflB , focA 954716 954722 96.0 ttaataaataCGATCGATattgttactt   [2]
NarL-Phosphorylated repressor focAp3 pflB , focA 954725 954731 87.0 aatttgtattTAATAAATacgatcgata   [2]
NarL-Phosphorylated repressor focAp3 pflB , focA 954743 954749 69.0 ataaggttaaATATCGGTaatttgtatt   [2]
NarL-Phosphorylated repressor focAp3 pflB , focA 954760 954766 52.0 ataaaataatTGTAATTAtaaggttaaa   [2]
NarL-Phosphorylated repressor focAp3 pflB , focA 954776 954782 36.0 acatatatttGCATTAATaaaataattg   [2]
NarL-Phosphorylated repressor focAp3 pflB , focA 954838 954844 -27.0 caatgtaggcTTAATGATtagtctgagt   [2]
NarL-Phosphorylated repressor focAp3 pflB , focA 954836 954842 -25.0 atgtaggcttAATGATTAgtctgagtta    
NarL-Phosphorylated repressor dcuSp dcuR , dcuS 4351722 4351728 -40.0 ccaatcattcTTACTCCCtttgaattac   [3]
NarL-Phosphorylated repressor dcuSp dcuR , dcuS 4351713 4351719 -31.0 cttactccctTTGAATTAcccgcctcat   [3]
NarL-Phosphorylated repressor ynfEp ynfE , ynfF , ynfG , ynfH , dmsD 1657986 1657992 -14.0 ttaacccaaaATGGGTAGactccctcta   [4]
NarL-Phosphorylated repressor ynfEp ynfE , ynfF , ynfG , ynfH , dmsD 1657977 1657983 -23.0 taataattctTAACCCAAaatgggtaga   [4]
FNR activator ynfEp ynfE , ynfF , ynfG , ynfH , dmsD 1657956 1657970 -40.5 tacccttctaTTGATATGGATTAATaattcttaac   [5]
[4]
FNR activator adhEp2 adhE 1298345 1298358 -42.5 tttgcaaaaaTTTGATTTGGATCACgtaatcagta   [1]
FNR activator focAp3 pflB , focA 954866 954879 -58.5 agcattctggGCAAAATAAAATCAAatagcctacg   [6]
FNR activator dcuSp dcuR , dcuS

Reference(s): [1] Membrillo-Hernandez J., et al., 1999
[2] Kaiser M., et al., 1995
[3] Goh EB., et al., 2005
[4] Xu M., et al., 2009
[5] Constantinidou C., et al., 2006
[6] Drapal N., et al., 1995



Reference(s)    

 [1] Membrillo-Hernandez J., Lin EC., 1999, Regulation of expression of the adhE gene, encoding ethanol oxidoreductase in Escherichia coli: transcription from a downstream promoter and regulation by fnr and RpoS., J Bacteriol 181(24):7571-9

 [2] Kaiser M., Sawers G., 1995, Nitrate repression of the Escherichia coli pfl operon is mediated by the dual sensors NarQ and NarX and the dual regulators NarL and NarP., J Bacteriol 177(13):3647-55

 [3] Goh EB., Bledsoe PJ., Chen LL., Gyaneshwar P., Stewart V., Igo MM., 2005, Hierarchical control of anaerobic gene expression in Escherichia coli K-12: the nitrate-responsive NarX-NarL regulatory system represses synthesis of the fumarate-responsive DcuS-DcuR regulatory system., J Bacteriol 187(14):4890-9

 [4] Xu M., Busby SJ., Browning DF., 2009, Activation and repression at the Escherichia coli ynfEFGHI operon promoter., J Bacteriol 191(9):3172-6

 [5] Constantinidou C., Hobman JL., Griffiths L., Patel MD., Penn CW., Cole JA., Overton TW., 2006, A reassessment of the FNR regulon and transcriptomic analysis of the effects of nitrate, nitrite, NarXL, and NarQP as Escherichia coli K12 adapts from aerobic to anaerobic growth., J Biol Chem 281(8):4802-15

 [6] Drapal N., Sawers G., 1995, Promoter 7 of the Escherichia coli pfl operon is a major determinant in the anaerobic regulation of expression by ArcA., J Bacteriol 177(18):5338-41

 [7] Salmon K., Hung SP., Mekjian K., Baldi P., Hatfield GW., Gunsalus RP., 2003, Global gene expression profiling in Escherichia coli K12. The effects of oxygen availability and FNR., J Biol Chem 278(32):29837-55


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