RegulonDB RegulonDB 10.9: Regulon Form
   
   


DnaA,Fis,ppGpp regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
Fis Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class TFs for DNA-bending
Synonym(s): DNA-binding transcriptional dual regulator Fis, Nbp, site-specific DNA inversion stimulation factor
Gene name(s): fis
Functional conformation(s): Fis
Coregulator(s): AcrR, AdiY, AppY, ArcA, ArgP, BasR, CRP, CpxR, Cra, CreB, CspA, CusR, CytR, DeoR, DksA, DksA-ppGpp, DnaA, FNR, FadR, Fis, FlhDC, FliZ, Fur, GadE, GadE-RcsB, GadW, GadX, GlcC, GlpR, H-NS, HprR, IHF, IscR, LeuO, Lrp, MalT, MarA, MarR, MazE, MazE-MazF, Mlc, MntR, ModE, NanR, NarL, NarP, NrdR, NsrR, NtrC, OmpR, OxyR, PdhR, PepA, PurR, RcsB, RcsB-BglJ, Rob, RstA, RutR, SlyA, SoxS, StpA, TorR, XylR, YdeO, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
DnaA Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class Using internal synthesized signals
Synonym(s): chromosomal replication initiator protein DnaA, chromosomal replication initiator protein/DNA-binding transcriptional dual regulator DnaA
Gene name(s): dnaA
Functional conformation(s): DnaA-ATP , DnaA
Coregulator(s): ArcA, ArgP, CRP, CytR, DnaA, FNR, Fis, H-NS, LexA, MarA, NrdR, PurR, Rob, SoxS, ppGpp
Summary: TF Summary ...[more]

REGULATION EXERTED BY DnaA,Fis,ppGpp Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
DnaA dual Fis repressor ppGpp inhibition    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
DnaA-ATP repressor dnaAp2 recF , dnaN , dnaA 3883935 3883943 -57.0 aaagtcctgtGGATAAATCGggaaaatctg   [1]
[2]
DnaA-ATP activator dnaAp2 recF , dnaN , dnaA 3883939 3883948 -61.0 ctggaaagtcCTGTGGATAAatcgggaaaa   [3]
DnaA-ATP activator dnaAp2 recF , dnaN , dnaA 3883918 3883927 -40.0 tcgggaaaatCTGTGAGAAAcagaagatct   [3]
DnaA-ATP activator dnaAp2 recF , dnaN , dnaA 3883929 3883938 -51.0 ctgtggataaATCGGGAAAAtctgtgagaa   [3]
DnaA-ATP activator dnaAp2 recF , dnaN , dnaA 3883951 3883960 -73.0 acttagcgagTTCTGGAAAGtcctgtggat   [3]
DnaA-ATP repressor dnaAp2 recF , dnaN , dnaA 3883929 3883938 -51.0 ctgtggataaATCGGGAAAAtctgtgagaa   [3]
DnaA-ATP repressor dnaAp2 recF , dnaN , dnaA 3883951 3883960 -73.0 acttagcgagTTCTGGAAAGtcctgtggat   [3]
DnaA-ATP repressor dnaAp2 recF , dnaN , dnaA 3883939 3883948 -61.0 ctggaaagtcCTGTGGATAAatcgggaaaa   [3]
DnaA-ATP repressor dnaAp2 recF , dnaN , dnaA 3883918 3883927 -40.0 tcgggaaaatCTGTGAGAAAcagaagatct   [3]
Fis repressor dnaAp2 recF , dnaN , dnaA 3883901 3883915 -26.0 tgtgagaaacAGAAGATCTCTTGCGCagtttaggct   [4]

Reference(s): [1] Lee Y., et al., 1997
[2] Lee YS., et al., 1996
[3] Saggioro C., et al., 2013
[4] Froelich JM., et al., 1996



Reference(s)    

 [1] Lee Y., Lee H., Yim J., Hwang D., 1997, The binding of two dimers of IciA protein to the dnaA promoter 1P element enhances the binding of RNA polymerase to the dnaA promoter 1P., Nucleic Acids Res 25(17):3486-9

 [2] Lee YS., Kim H., Hwang DS., 1996, Transcriptional activation of the dnaA gene encoding the initiator for oriC replication by IciA protein, an inhibitor of in vitro oriC replication in Escherichia coli., Mol Microbiol 19(2):389-96

 [3] Saggioro C., Olliver A., Sclavi B., 2013, Temperature-dependence of the DnaA-DNA interaction and its effect on the autoregulation of dnaA expression., Biochem J 449(2):333-41

 [4] Froelich JM., Phuong TK., Zyskind JW., 1996, Fis binding in the dnaA operon promoter region., J Bacteriol 178(20):6006-12


RegulonDB