RegulonDB RegulonDB 10.9: Regulon Form
   
   


HypT,MetJ,PhoP regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
PhoP Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class External-Two-component systems
Synonym(s): DNA-binding transcriptional dual regulator PhoP, PhoP response regulator
Gene name(s): phoP
Functional conformation(s): PhoP-Phosphorylated , PhoP
Coregulator(s): AcrR, ArcA, ArgR, BasR, CRP, CysB, EnvR, EvgA, FNR, FadR, FliZ, GadE, GadW, GadX, H-NS, HypT, Lrp, MalT, MarA, MetJ, MprA, NagC, NarL, NarP, NtrC, OmpR, PdhR, PhoP, PurR, RbsR, RcsB, Rob, RutR, SdiA, SlyA, SoxR, SoxS, TorR, UvrY, YdeO, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
MetJ Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class Using internal synthesized signals
Synonym(s): B3938, MetJ, MetJ-SAM
Gene name(s): metJ
Functional conformation(s): MetJ-S-adenosylmethionine , MetJ-adenine , MetJ-MTA , MetJ
Coregulator(s): CRP, HypT, MetJ, MetR, OxyR, PhoP
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
HypT      Tractordb tool
Connectivity class Local Regulator
Synonym(s): DNA-binding transcriptional dual regulator HypT, QseD, YjiE
Gene name(s): hypT
Functional conformation(s): HypT-Met-oxidized
Coregulator(s): ArcA, AscG, CRP, FNR, Fur, H-NS, HypT, MetJ, PdhR, PhoP
Summary: TF Summary ...[more]

REGULATION EXERTED BY HypT,MetJ,PhoP Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
HypT activator MetJ repressor PhoP activator    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
PhoP-Phosphorylated activator metBp metB , metL 4128608 4128624 -20.0 tattgacgtcCATTAACACAATGTTTACtctggtgcct   [1]
MetJ-S-adenosylmethionine repressor metBp metB , metL 4128598 4128613 -30.5 tgtccagatgTATTGACGTCCATTAACacaatgttta   [2]
[3]
[4]
MetJ-S-adenosylmethionine repressor metBp metB , metL 4128588 4128603 -40.5 gaagtttagaTGTCCAGATGTATTGACgtccattaac   [2]
[3]
[4]
MetJ-S-adenosylmethionine repressor metBp metB , metL 4128590 4128605 -38.5 agtttagatgTCCAGATGTATTGACGTccattaacac   [2]
[3]
[4]
MetJ-S-adenosylmethionine repressor metBp metB , metL 4128580 4128595 -48.5 tacgcaaagaAGTTTAGATGTCCAGATgtattgacgt   [2]
[3]
[4]
MetJ-S-adenosylmethionine repressor metBp metB , metL 4128582 4128597 -46.5 cgcaaagaagTTTAGATGTCCAGATGTattgacgtcc   [2]
[3]
[4]
MetJ-S-adenosylmethionine repressor metBp metB , metL 4128572 4128587 -56.5 tcaatctataCGCAAAGAAGTTTAGATgtccagatgt   [2]
[3]
[4]
HypT-Met-oxidized activator metBp metB , metL

Reference(s): [1] Monsieurs P., et al., 2005
[2] Kirby TW., et al., 1986
[3] Liu R., et al., 2001
[4] Marincs F., et al., 2006



Reference(s)    

 [1] Monsieurs P., De Keersmaecker S., Navarre WW., Bader MW., De Smet F., McClelland M., Fang FC., De Moor B., Vanderleyden J., Marchal K., 2005, Comparison of the PhoPQ regulon in Escherichia coli and Salmonella typhimurium., J Mol Evol 60(4):462-74

 [2] Kirby TW., Hindenach BR., Greene RC., 1986, Regulation of in vivo transcription of the Escherichia coli K-12 metJBLF gene cluster., J Bacteriol 165(3):671-7

 [3] Liu R., Blackwell TW., States DJ., 2001, Conformational model for binding site recognition by the E.coli MetJ transcription factor., Bioinformatics 17(7):622-33

 [4] Marincs F., Manfield IW., Stead JA., McDowall KJ., Stockley PG., 2006, Transcript analysis reveals an extended regulon and the importance of protein-protein co-operativity for the Escherichia coli methionine repressor., Biochem J 396(2):227-34

 [5] Drazic A., Miura H., Peschek J., Le Y., Bach NC., Kriehuber T., Winter J., 2013, Methionine oxidation activates a transcription factor in response to oxidative stress., Proc Natl Acad Sci U S A 110(23):9493-8

 [6] Gebendorfer KM., Drazic A., Le Y., Gundlach J., Bepperling A., Kastenmuller A., Ganzinger KA., Braun N., Franzmann TM., Winter J., 2012, Identification of a Hypochlorite-specific Transcription Factor from Escherichia coli., J Biol Chem 287(9):6892-903


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