RegulonDB RegulonDB 10.9: Regulon Form
   
   


CRP,CytR,NsrR regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
CRP Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class Using internal synthesized signals
Synonym(s): Cap, Csm, DNA-binding transcriptional dual regulator CRP, GurB
Gene name(s): crp
Functional conformation(s): CRP-cAMP , CRP
Coregulator(s): AcrR, AdiY, AgaR, AraC, ArcA, ArgP, ArgR, AscG, BasR, BolA, BtsR, CRP, CRP-Sxy, CaiF, ChbR, ComR, CpxR, Cra, CreB, CsgD, CspA, CsqR, CusR, CytR, DcuR, DeoR, DgoR, DksA-ppGpp, DnaA, DpiA, DsdC, EbgR, EnvY, EvgA, ExuR, FNR, FadR, FeaR, FhlA, Fis, FlhDC, FliZ, FucR, Fur, GadE, GadE-RcsB, GadW, GadX, GalR, GalS, GatR, GcvA, GlaR, GlcC, GlpR, GlrR, GntR, GutM, H-NS, HU, HdfR, HipB, HprR, HyfR, HypT, IHF, IclR, IdnR, LacI, LeuO, LexA, LrhA, Lrp, LsrR, MalI, MalT, MarA, MarR, MatA, McbR, MelR, MetJ, MhpR, Mlc, MlrA, ModE, MprA, MqsA, MurR, Nac, NadR, NagC, NanR, NarL, NarP, NrdR, NsrR, NtrC, OmpR, OxyR, PaaX, PdhR, PhoB, PhoP, PrpR, PurR, PuuR, QseB, RbsR, RcdA, RcsAB, RcsB, RcsB-BglJ, RhaR, RhaS, Rob, RstA, SdiA, SlyA, SoxR, SoxS, SrlR, StpA, TdcA, TdcR, TorR, TreR, UhpA, UidR, UlaR, UvrY, UxuR, XylR, YdeO, YiaJ, YjjQ, ZraR, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
CytR Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class Sensing external and internal signals
Synonym(s): DNA-binding transcriptional repressor CytR
Gene name(s): cytR
Functional conformation(s): CytR , CytR-cytidine
Coregulator(s): CRP, CytR, DeoR, DnaA, Fis, ModE, Nac, NsrR
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
NsrR Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Synonym(s): DNA-binding transcriptional repressor NsrR, YjeB
Gene name(s): nsrR
Functional conformation(s): NsrR-nitric oxide , NsrR , NsrR-[2Fe-2S]2+ oxidized , NsrR-[2Fe-2S]reduced
Coregulator(s): ArcA, CRP, CpxR, CsgD, CytR, DksA, DksA-ppGpp, DsdC, FNR, FeaR, FhlA, Fis, FlhDC, Fur, GadE, H-NS, IHF, IscR, Lrp, MatA, MetR, ModE, Nac, NarL, NarP, NorR, NsrR, OxyR, PdhR, PhoB, QseB, SutR, ppGpp
Summary: TF Summary ...[more]

REGULATION EXERTED BY CRP,CytR,NsrR Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
CRP dual CytR repressor NsrR repressor    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
CRP-cAMP activator cddp cdd 2231716 2231737 -92.5 atgggctaaaATTTGCGATGCGTCGCGCATTTTtgatgtatgt   [1]
[2]
CRP-cAMP activator cddp cdd 2231766 2231787 -42.5 gttgcataatTAATGAGATTCAGATCACATATAaagccacaac   [1]
[2]
CRP-cAMP repressor cddp cdd 2231714 2231735 -94.5 taatgggctaAAATTTGCGATGCGTCGCGCATTtttgatgtat   [1]
[2]
CytR repressor cddp cdd 2231729 2231745 -82.5 tgcgatgcgtCGCGCATTTTTGATGTAtgtttcacgc   [1]
[3]
[4]
CytR repressor cddp cdd 2231747 2231764 -64.0 tttgatgtatGTTTCACGCGTTGCATAAttaatgagat   [1]
[3]
[4]
[2]
CRP-cAMP repressor cddp cdd 2231766 2231787 -42.5 gttgcataatTAATGAGATTCAGATCACATATAaagccacaac   [1]
[2]
NsrR repressor cddp cdd 2231822 2231833 9.0 gttatcccatTACATGATTATGaggcaacgcc   [5]

Reference(s): [1] Holst B., et al., 1992
[2] Valentin-Hansen P., et al., 1989
[3] Holt AK., et al., 2010
[4] Jorgensen CI., et al., 1998
[5] Partridge JD., et al., 2009



Reference(s)    

 [1] Holst B., Sogaard-Andersen L., Pedersen H., Valentin-Hansen P., 1992, The cAMP-CRP/CytR nucleoprotein complex in Escherichia coli: two pairs of closely linked binding sites for the cAMP-CRP activator complex are involved in combinatorial regulation of the cdd promoter., EMBO J 11(10):3635-43

 [2] Valentin-Hansen P., Holst B., Josephsen J., Hammer K., Albrechtsen B., 1989, CRP/cAMP- and CytR-regulated promoters in Escherichia coli K12: the cdd promoter., Mol Microbiol 3(10):1385-90

 [3] Holt AK., Senear DF., 2010, An unusual pattern of CytR and CRP binding energetics at Escherichia coli cddP suggests a unique blend of class I and class II mediated activation., Biochemistry 49(3):432-42

 [4] Jorgensen CI., Kallipolitis BH., Valentin-Hansen P., 1998, DNA-binding characteristics of the Escherichia coli CytR regulator: a relaxed spacing requirement between operator half-sites is provided by a flexible, unstructured interdomain linker., Mol Microbiol 27(1):41-50

 [5] Partridge JD., Bodenmiller DM., Humphrys MS., Spiro S., 2009, NsrR targets in the Escherichia coli genome: new insights into DNA sequence requirements for binding and a role for NsrR in the regulation of motility., Mol Microbiol 73(4):680-94


RegulonDB