RegulonDB RegulonDB 10.9: Regulon Form
   
   


Cbl,CysB,FNR,IHF regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
FNR Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class Using internal synthesized signals
Synonym(s): DNA-binding transcriptional dual regulator FNR, NirA, NirR, OssA, OxrA
Gene name(s): fnr
Functional conformation(s): FNR , FNR-[4Fe-4S]2+ reduced , FNR-[2Fe-2S]2+ oxidized
Coregulator(s): AcrR, AdiY, ArcA, ArgP, ArgR, BtsR, CRP, CadC, CaiF, Cbl, CdaR, Cra, CueR, CusR, CysB, DcuR, DksA, DksA-ppGpp, DnaA, DpiA, EvgA, ExuR, FNR, FhlA, Fis, FlhDC, Fur, GadE, GadE-RcsB, GadW, GadX, GcvA, GlpR, H-NS, HdfR, HprR, HyfR, HypT, IHF, LeuO, Lrp, MalT, MarA, MetR, MlrA, ModE, Nac, NagC, NarL, NarP, NfeR, NikR, NorR, NrdR, NsrR, NtrC, OmpR, OxyR, PdhR, PhoB, PhoP, PurR, PuuR, RcsB, Rob, RstA, RutR, SlyA, SoxR, SoxS, TdcA, TdcR, TorR, YeiL, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
CysB Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class Sensing external and internal signals
Synonym(s): DNA-binding transcriptional dual regulator CysB, positive transcriptional regulator for cysteine regulon
Gene name(s): cysB
Functional conformation(s): CysB , CysB-O-acetyl-L-serine , CysB-N-acetyl-L-serine , CysB-Sulphide , CysB-Thiosulfate
Coregulator(s): ArcA, Cbl, CpxR, CysB, FNR, H-NS, IHF, NtrC, PhoP
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
Cbl      Tractordb tool
Connectivity class Local Regulator
Sensing Class Using internal synthesized signals
Synonym(s): DNA-binding transcriptional activator Cbl
Gene name(s): cbl
Functional conformation(s): Cbl , Cbl-APS , Cbl-Thiosulphate
Coregulator(s): Cbl, CysB, FNR, IHF
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
IHF Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Synonym(s): DNA-binding transcriptional dual regulator IHF
Gene name(s): ihfB, ihfA
Functional conformation(s): IHF
Coregulator(s): AcrR, AdiY, ArcA, ArgR, AtoC, BasR, BolA, BtsR, CRP, Cbl, CpxR, Cra, CsgD, CysB, DksA, DksA-ppGpp, EnvY, FNR, FadR, FhlA, Fis, FlhDC, FliZ, Fur, GadE, GlcC, GlpR, GlrR, H-NS, HU, HdfR, HipAB, HipB, IHF, IclR, IscR, LrhA, Lrp, MarA, MatA, MlrA, MntR, ModE, MprA, MqsA, Nac, NagC, NanR, NarL, NarP, NorR, NsrR, NtrC, OmpR, OxyR, PaaX, PdhR, PepA, PhoB, PspF, PurR, QseB, RcdA, RcsAB, Rob, RstA, RtcR, RutR, SlyA, SoxR, SoxS, SutR, TdcA, TdcR, TrpR, TyrR, UlaR, UvrY, YeiL, YiaJ, YjjQ, ppGpp
Summary: TF Summary ...[more]

REGULATION EXERTED BY Cbl,CysB,FNR,IHF Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
Cbl activator CysB repressor FNR activator IHF dual    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
IHF activator ssuEp ssuB , ssuC , ssuD , ssuA , ssuE 997691 997703 -134.0 aactgaacgaGTAATTCATTGATTcaacatctaa   [1]
IHF activator ssuEp ssuB , ssuC , ssuD , ssuA , ssuE 997734 997746 -177.0 tgacaaatctTTAATTTATAGATTtcatgaatat   [1]
Cbl activator ssuEp ssuB , ssuC , ssuD , ssuA , ssuE 997598 997637 -54.5 taaagcccttTCTTTAGTTTATTTTCAGAAAAAGATACACAAAATTTATATttggaatttt   [2]
IHF repressor ssuEp ssuB , ssuC , ssuD , ssuA , ssuE 997525 997537 33.0 taacaaaaaaAGAACAATTGGTTAtaaggagaga   [1]
CysB-O-acetyl-L-serine repressor ssuEp ssuB , ssuC , ssuD , ssuA , ssuE 997560 997601 -18.0 acacaaaattTATATTTGGAATTTTCTTGTCTCTCCGACAGACTGACCGAATTgttatcaatg   [2]
[1]
FNR activator ssuEp ssuB , ssuC , ssuD , ssuA , ssuE

Reference(s): [1] van Der Ploeg JR., et al., 1999
[2] Bykowski T., et al., 2002



Reference(s)    

 [1] van Der Ploeg JR., Iwanicka-Nowicka R., Bykowski T., Hryniewicz MM., Leisinger T., 1999, The Escherichia coli ssuEADCB gene cluster is required for the utilization of sulfur from aliphatic sulfonates and is regulated by the transcriptional activator Cbl., J Biol Chem 274(41):29358-65

 [2] Bykowski T., van der Ploeg JR., Iwanicka-Nowicka R., Hryniewicz MM., 2002, The switch from inorganic to organic sulphur assimilation in Escherichia coli: adenosine 5'-phosphosulphate (APS) as a signalling molecule for sulphate excess., Mol Microbiol 43(5):1347-58

 [3] Salmon K., Hung SP., Mekjian K., Baldi P., Hatfield GW., Gunsalus RP., 2003, Global gene expression profiling in Escherichia coli K12. The effects of oxygen availability and FNR., J Biol Chem 278(32):29837-55


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