RegulonDB RegulonDB 10.9: Regulon Form
   
   


ArgP,Lrp regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
ArgP Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class Using internal synthesized signals
Synonym(s): DNA-binding transcriptional dual regulator ArgP, IciA
Gene name(s): argP
Functional conformation(s): ArgP-lysine , ArgP-arginine , ArgP
Coregulator(s): ArgP, CRP, DnaA, FNR, Fis, Fur, H-NS, Lrp, LysR, Nac, NrdR, PhoB, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
Lrp Weight Matrix      Tractordb tool
Connectivity class Global Regulator
Sensing Class Sensing external and internal signals
Synonym(s): AlsB, DNA-binding transcriptional dual regulator Lrp, Ihb, LivR, Lrs, Lss, LstR, Mbf, OppI, RblA
Gene name(s): lrp
Functional conformation(s): Lrp-leucine , Lrp
Coregulator(s): AcrR, Ada, AdiY, AidB, ArcA, ArgP, ArgR, CRP, CadC, CpxR, Cra, DksA, DksA-ppGpp, EnvY, FNR, Fis, FliZ, Fur, GadE, GadE-RcsB, GadW, GadX, GcvA, GlaR, H-NS, HU, HdfR, IHF, LrhA, Lrp, MarA, Mlc, ModE, Nac, NarL, NhaR, NsrR, OmpR, PhoP, PurR, QseB, RcsB, Rob, SoxS, StpA, TorR, YeiL, YjjQ, ppGpp
Summary: TF Summary ...[more]

REGULATION EXERTED BY ArgP,Lrp Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
ArgP activator Lrp activator    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
ArgP-arginine activator argOp argO 3068860 3068879 -33.5 gccaattaatATTATCAATTTCCGCTAATAAcaatcccgcg   [1]
[2]
[3]
[4]
[5]
Lrp-leucine activator argOp argO 3068873 3068889 -44.5 tttctgattgCCAATTAATATTATCAAtttccgctaa   [5]
Lrp-leucine activator argOp argO 3068894 3068910 -65.5 ctggcctctcTCTTATTAGTTTTTCTGattgccaatt   [5]
Lrp-leucine activator argOp argO 3068918 3068934 -89.5 aacgctgaggCCAGATAATACTCTCTGgcctctctct   [5]
ArgP activator lysPp lysP 2248633 2248652 -82.5 agagattggcTGCTTTACTTATAATCCCTGGgcgatcatga   [3]
[4]
[6]
ArgP-arginine activator argOp argO 3068880 3068900 -53.5 tcttattagtTTTTCTGATTGCCAATTAATAttatcaattt   [2]
[3]
[7]
[4]
[5]
ArgP activator lysPp lysP 2248613 2248632 -62.5 ataatccctgGGCGATCATGAAGGTGTCTTAtaaccgtgta   [3]
[4]
[6]
Lrp activator lysPp lysP

Reference(s): [1] Bouvier J., et al., 2008
[2] Laishram RS., et al., 2007
[3] Marbaniang CN., et al., 2011
[4] Nguyen Le Minh P., et al., 2018
[5] Peeters E., et al., 2009
[6] Ruiz J., et al., 2011
[7] Nandineni MR., et al., 2004



Reference(s)    

 [1] Bouvier J., Stragier P., Morales V., Remy E., Gutierrez C., 2008, Lysine represses transcription of the Escherichia coli dapB gene by preventing its activation by the ArgP activator., J Bacteriol 190(15):5224-9

 [2] Laishram RS., Gowrishankar J., 2007, Environmental regulation operating at the promoter clearance step of bacterial transcription., Genes Dev 21(10):1258-72

 [3] Marbaniang CN., Gowrishankar J., 2011, Role of ArgP (IciA) in Lysine-Mediated Repression in Escherichia coli., J Bacteriol 193(21):5985-96

 [4] Nguyen Le Minh P., Velazquez Ruiz C., Vandermeeren S., Abwoyo P., Bervoets I., Charlier D., 2018, Differential protein-DNA contacts for activation and repression by ArgP, a LysR-type (LTTR) transcriptional regulator in Escherichia coli., Microbiol Res 206:141-158

 [5] Peeters E., Nguyen Le Minh P., Foulquie-Moreno M., Charlier D., 2009, Competitive activation of the Escherichia coli argO gene coding for an arginine exporter by the transcriptional regulators Lrp and ArgP., Mol Microbiol 74(6):1513-26

 [6] Ruiz J., Haneburger I., Jung K., 2011, Identification of ArgP and Lrp as transcriptional regulators of lysP, the gene encoding the specific lysine permease of Escherichia coli., J Bacteriol 193(10):2536-48

 [7] Nandineni MR., Gowrishankar J., 2004, Evidence for an arginine exporter encoded by yggA (argO) that is regulated by the LysR-type transcriptional regulator ArgP in Escherichia coli., J Bacteriol 186(11):3539-46


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