RegulonDB RegulonDB 10.9: Regulon Form
   
   


TrpR,TyrR regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
TyrR Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class Sensing external and internal signals
Synonym(s): DNA-binding transcriptional dual regulator TyrR
Gene name(s): tyrR
Functional conformation(s): TyrR-L-tyrosine , TyrR , TyrR-L-phenylalanine , TyrR-L-tryptophan
Coregulator(s): CpxR, Cra, HU, IHF, PgrR, SoxR, TrpR, TyrR
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
TrpR Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class Sensing external and internal signals
Synonym(s): DNA-binding transcriptional repressor TrpR, RtrY
Gene name(s): trpR
Functional conformation(s): rpR-L-tryptophan , TrpR
Coregulator(s): HU, IHF, TrpR, TyrR
Summary: TF Summary ...[more]

REGULATION EXERTED BY TrpR,TyrR Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
TrpR repressor TyrR repressor    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
rpR-L-tryptophan repressor aroLp aroL , yaiA , aroM 406319 406336 48.5 ttctttacaaTCGAAATTGTACTAGTTTGatggtatgat   [1]
[2]
[3]
[4]
TyrR-L-tyrosine repressor aroLp aroL , yaiA , aroM 406226 406243 -45.0 tggctaaatgTAATTTATTATTTACACTTcattcttgaa   [5]
[1]
[3]
TyrR-L-tyrosine repressor aroLp aroL , yaiA , aroM 406282 406299 12.0 aggggtgtatTGAGATTTTCACTTTAAGTggaatttttt   [5]
[1]
[3]
TyrR-L-tyrosine repressor aroLp aroL , yaiA , aroM 406301 406318 31.0 cactttaagtGGAATTTTTTCTTTACAATcgaaattgta   [5]
[1]
[3]
rpR-L-tryptophan repressor aroLp aroL , yaiA , aroM 406327 406344 56.5 aatcgaaattGTACTAGTTTGATGGTATGatcgctattc   [1]
[2]
[3]
[4]

Reference(s): [1] Heatwole VM., et al., 1992
[2] Jeeves M., et al., 1999
[3] Lawley B., et al., 1994
[4] Yang J., et al., 1996
[5] DeFeyter RC., et al., 1986



Reference(s)    

 [1] Heatwole VM., Somerville RL., 1992, Synergism between the Trp repressor and Tyr repressor in repression of the aroL promoter of Escherichia coli K-12., J Bacteriol 174(1):331-5

 [2] Jeeves M., Evans PD., Parslow RA., Jaseja M., Hyde EI., 1999, Studies of the Escherichia coli Trp repressor binding to its five operators and to variant operator sequences., Eur J Biochem 265(3):919-28

 [3] Lawley B., Pittard AJ., 1994, Regulation of aroL expression by TyrR protein and Trp repressor in Escherichia coli K-12., J Bacteriol 176(22):6921-30

 [4] Yang J., Gunasekera A., Lavoie TA., Jin L., Lewis DE., Carey J., 1996, In vivo and in vitro studies of TrpR-DNA interactions., J Mol Biol 258(1):37-52

 [5] DeFeyter RC., Davidson BE., Pittard J., 1986, Nucleotide sequence of the transcription unit containing the aroL and aroM genes from Escherichia coli K-12., J Bacteriol 165(1):233-9


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