RegulonDB RegulonDB 10.9: Regulon Form
   
   


CsgD,FlhDC regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
CsgD Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Synonym(s): DNA-binding transcriptional dual regulator CsgD
Gene name(s): csgD
Functional conformation(s): CsgD
Coregulator(s): BasR, BolA, BtsR, CRP, CpxR, Cra, CsgD, DksA-ppGpp, FlhDC, FliZ, H-NS, IHF, MatA, MlrA, MqsA, NsrR, OmpR, RcdA, RcsAB, RstA, SutR, ppGpp
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
FlhDC Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Synonym(s): FlhDC DNA-binding transcriptional dual regulator
Gene name(s): flhC, flhD
Functional conformation(s): FlhDC
Coregulator(s): ArcA, BtsR, CRP, CsgD, DpiA, FNR, FhlA, Fis, FlhDC, GalR, GalS, GlpR, H-NS, IHF, MatA, ModE, NarL, NarP, NsrR, SutR
Summary: TF Summary ...[more]

REGULATION EXERTED BY CsgD,FlhDC Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
CsgD repressor FlhDC activator    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
FlhDC activator fliEp1 fliE 2013097 2013113 -69.0 ttcgttttttTCTATCCGCCAATAAACCcgtttttttg   [1]
[2]
FlhDC activator fliEp1 fliE 2013068 2013086 -40.5 cgtttttttgTTGCTATTTAGCGCCTTTGtcttattgac   [1]
[2]
FlhDC activator fliFp1 fliF , fliG , fliH , fliI , fliJ , fliK 2013068 2013086 -69.5 gtcaataagaCAAAGGCGCTAAATAGCAAcaaaaaaacg    
FlhDC activator fliFp1 fliF , fliG , fliH , fliI , fliJ , fliK 2013097 2013113 -41.0 caaaaaaacgGGTTTATTGGCGGATAGAaaaaaacgaa    
CsgD repressor fliFp1 fliF , fliG , fliH , fliI , fliJ , fliK 2013069 2013083 -70.5 tcaataagacAAAGGCGCTAAATAGcaacaaaaaa   [3]
CsgD repressor fliFp1 fliF , fliG , fliH , fliI , fliJ , fliK 2013054 2013068 -85.5 aagcctaccaGTAAGTCAATAAGACaaaggcgcta   [3]
CsgD repressor fliEp1 fliE 2013054 2013068 -24.5 tagcgcctttGTCTTATTGACTTACtggtaggctt [APIORCISFBSCS]
[BPP]
[GEA]
[3]
CsgD repressor fliEp1 fliE 2013069 2013083 -39.5 ttttttgttgCTATTTAGCGCCTTTgtcttattga [APIORCISFBSCS]
[BPP]
[GEA]
[3]

Evidence: [APIORCISFBSCS] A person inferred or reviewed a computer inference of sequence function based on similarity to a consensus sequence.
[BPP] Binding of purified proteins
[GEA] Gene expression analysis
Reference(s): [1] Brandi A., et al., 2016
[2] Stafford GP., et al., 2005
[3] Ogasawara H., et al., 2011



Reference(s)    

 [1] Brandi A., Giangrossi M., Giuliodori AM., Falconi M., 2016, An Interplay among FIS, H-NS, and Guanosine Tetraphosphate Modulates Transcription of the Escherichia coli cspA Gene under Physiological Growth Conditions., Front Mol Biosci 3:19

 [2] Stafford GP., Ogi T., Hughes C., 2005, Binding and transcriptional activation of non-flagellar genes by the Escherichia coli flagellar master regulator FlhD2C2., Microbiology 151(Pt 6):1779-88

 [3] Ogasawara H., Yamamoto K., Ishihama A., 2011, Role of the biofilm master regulator CsgD in cross-regulation between biofilm formation and flagellar synthesis., J Bacteriol 193(10):2587-97


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