RegulonDB RegulonDB 10.9: Regulon Form
   
   


Fur,RcnR regulon in Escherichia coli K-12 genome


TRANSCRIPTION FACTOR: Info
Name:
RcnR      Tractordb tool
Connectivity class Local Regulator
Synonym(s): DNA-binding transcriptional repressor RcnR, YohL
Gene name(s): rcnR
Functional conformation(s): RcnR-Ni2+ , RcnR-Co2+ , RcnR
Coregulator(s): Fur, RcnR
Summary: TF Summary ...[more]
TRANSCRIPTION FACTOR: Info
Name:
Fur Weight Matrix      Tractordb tool
Connectivity class Local Regulator
Sensing Class External sensing using transported metabolites
Synonym(s): DNA-binding transcriptional dual regulator Fur
Gene name(s): fur
Functional conformation(s): Fur-Fe2+ , Fur , Fur-Mn2+
Coregulator(s): AcrR, AdiY, ArcA, ArgP, ArgR, AscG, CRP, CdaR, CpxR, Cra, CusR, EnvY, FNR, Fis, FliZ, Fur, GadE, GadX, H-NS, HdfR, HprR, HypT, IHF, IscR, LrhA, Lrp, MarA, MatA, MetR, MntR, ModE, MqsA, Nac, NagC, NarL, NfeR, NrdR, NsrR, NtrC, OmpR, OxyR, PdhR, PhoB, PurR, QseB, RcnR, RcsAB, Rob, RstA, RutR, SlyA, SoxR, SoxS, YjjQ, Zur, ppGpp
Summary: TF Summary ...[more]

REGULATION EXERTED BY Fur,RcnR Info M3D | Colombos
KNOWN BINDING SITES (The central relative position is relative to the promoter +1)    
Fur repressor RcnR repressor    
Transcription Factor
Regulated
Binding Sites
Evidence
References
Functional conformation
Function
Promoter
Gene(s)
LeftPos
RigthPos
Central Rel-Pos
Sequence
RcnR repressor rcnAp rcnA , rcnB 2185865 2185879 46.5 tagtatcaggTACTGGGGGGGAGTAGaatcagattg   [1]
[2]
[3]
[4]
RcnR repressor rcnAp rcnA , rcnB 2185845 2185859 26.5 actattaatcTACTGGGGGGTAGTATcaggtactgg   [1]
[2]
[3]
[4]
Fur-Fe2+ repressor rcnAp rcnA , rcnB 2185897 2185918 81.0 attgccgaatTAATACTAAGAATTATTATCATgaccgaattt   [4]
Fur-Fe2+ repressor rcnAp rcnA , rcnB 2185903 2185924 87.0 gaattaatacTAAGAATTATTATCATGACCGAatttacaact   [4]
Fur-Fe2+ repressor rcnAp rcnA , rcnB 2185894 2185915 78.0 cagattgccgAATTAATACTAAGAATTATTATcatgaccgaa   [4]

Reference(s): [1] Blaha D., et al., 2011
[2] Iwig JS., et al., 2009
[3] Iwig JS., et al., 2006
[4] Koch D., et al., 2007



Reference(s)    

 [1] Blaha D., Arous S., Bleriot C., Dorel C., Mandrand-Berthelot MA., Rodrigue A., 2011, The Escherichia coli metallo-regulator RcnR represses rcnA and rcnR transcription through binding on a shared operator site: Insights into regulatory specificity towards nickel and cobalt., Biochimie 93(3):434-9

 [2] Iwig JS., Chivers PT., 2009, DNA recognition and wrapping by Escherichia coli RcnR., J Mol Biol 393(2):514-26

 [3] Iwig JS., Rowe JL., Chivers PT., 2006, Nickel homeostasis in Escherichia coli - the rcnR-rcnA efflux pathway and its linkage to NikR function., Mol Microbiol 62(1):252-62

 [4] Koch D., Nies DH., Grass G., 2007, The RcnRA (YohLM) system of Escherichia coli: a connection between nickel, cobalt and iron homeostasis., Biometals 20(5):759-71


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